Issue 88, 2023

Enaminone-directed ruthenium(ii)-catalyzed C–H activation and annulation of arenes with diazonaphthoquinones for polycyclic benzocoumarins

Abstract

The weakly coordinating enaminone functionality has been leveraged for a C–H bond activation strategy under ruthenium catalysis and employed in the regioselective annulative coupling of arenes with diazonaphthoquinones, offering polycyclic benzocoumarins in very high yields. The enaminone motif plays a dual role and the protocol operates through a Ru(II)/Ru(IV) catalytic pathway which is amenable to the diversification of various pharmacophore-coupled substrates.

Graphical abstract: Enaminone-directed ruthenium(ii)-catalyzed C–H activation and annulation of arenes with diazonaphthoquinones for polycyclic benzocoumarins

Supplementary files

Article information

Article type
Communication
Submitted
18 авг 2023
Accepted
04 окт 2023
First published
09 окт 2023

Chem. Commun., 2023,59, 13187-13190

Enaminone-directed ruthenium(II)-catalyzed C–H activation and annulation of arenes with diazonaphthoquinones for polycyclic benzocoumarins

S. Mondal, C. K. Giri and M. Baidya, Chem. Commun., 2023, 59, 13187 DOI: 10.1039/D3CC03999D

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