Issue 13, 2022

The indole nucleus as a selective COX-2 inhibitor and anti-inflammatory agent (2011–2022)

Abstract

Here we have outlined the recent (2011–2022) developments in the synthesis of modified indomethacin-based analogues for the selective inhibition of COX-2 and then highlighted the synthesis of indoles as inhibitors of other inflammatory mediators such as nitric oxide (NO) radicals, lipoxygenase (LOX) enzymes, reactive oxygen species (ROS) and interleukin (IL).

Graphical abstract: The indole nucleus as a selective COX-2 inhibitor and anti-inflammatory agent (2011–2022)

Article information

Article type
Review Article
Submitted
01 апр 2022
Accepted
12 май 2022
First published
16 май 2022

Org. Chem. Front., 2022,9, 3624-3639

The indole nucleus as a selective COX-2 inhibitor and anti-inflammatory agent (2011–2022)

Nisha, S. Singh, N. Sharma and R. Chandra, Org. Chem. Front., 2022, 9, 3624 DOI: 10.1039/D2QO00534D

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