Issue 5, 2022

Observing hepatic steatosis with a commercially viable two-photon fluorogenic probe

Abstract

The key mechanism of lipid droplet-related diseases and polarity remains undetermined due to a scarcity of research on numerous condition models. We developed a conventional donor–acceptor fluorogenic probe with the untwisted intramolecular charge process. It is near-infrared-excited two-photon LD-specific and polarity-sensitive. This probe can detect dynamic changes of LD polarity in cancer cells and visualizes aberrant LD polarity in hepatic steatosis models. In the future, it could be beneficial for clinical diagnosis of LD polarity-related symptoms and to track the origin of lipid droplets and to monitor polarity-relative subcellular organelles.

Graphical abstract: Observing hepatic steatosis with a commercially viable two-photon fluorogenic probe

Supplementary files

Article information

Article type
Research Article
Submitted
29 дек 2021
Accepted
19 яну 2022
First published
20 яну 2022

Mater. Chem. Front., 2022,6, 553-560

Observing hepatic steatosis with a commercially viable two-photon fluorogenic probe

J. Han, H. W. Lee, Y. Chen, H. Li, H. M. Kim and J. Yoon, Mater. Chem. Front., 2022, 6, 553 DOI: 10.1039/D1QM01665B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements