Issue 18, 2021

Recent developments in the difunctionalization of alkenes with C–N bond formation

Abstract

The difunctionalization of carbon–carbon double bonds, introducing two novel functional groups onto both sides of the carbon–carbon bond in one pot, has become more and more attractive as a powerful tool in the synthetic community to improve the complexity of molecules. Among the available approaches, the difunctionalization of alkenes involving nitridization, such as diamination, azidation, oxyamination, carboamination, aminohalogenation, nitration and so on, has always been a research hotspot in organic synthesis owing to the broad existence of N-containing functional groups in bioactive compounds, natural products, organic ligands, and other high-nitrogen energetic compounds. In this review, we focus on recent research progress relating to the difunctionalization of alkenes involving the participation of a N source, and some related mechanisms are also provided here. Although significant achievements have been reported, there is still some space for further developments. This review will facilitate an understanding of the difunctionalization of alkenes involving the participation of N atoms and it can further stimulate the additional development of novel synthesis strategies based on these reported alkene difunctionalization approaches.

Graphical abstract: Recent developments in the difunctionalization of alkenes with C–N bond formation

Article information

Article type
Review Article
Submitted
08 мар 2021
Accepted
10 юни 2021
First published
11 юни 2021

Org. Chem. Front., 2021,8, 5206-5228

Recent developments in the difunctionalization of alkenes with C–N bond formation

X. Chen, F. Xiao and W. He, Org. Chem. Front., 2021, 8, 5206 DOI: 10.1039/D1QO00375E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements