Issue 9, 2021

Porphyrin metalation catalyzed by DNAzymes and nanozymes

Abstract

Metalloporphyrins play important roles in biology, such as magnesium porphyrin for photosynthesis and iron porphyrin for carrying and transferring oxygen. They are also powerful molecules for the development of biosensors, phototherapy, photocatalysis, photodegradation, light harvesting, and water splitting. However, the porphyrin metalation reaction is difficult to achieve at room temperature due to a high kinetic barrier. Inspired by the pioneering work in catalytic antibodies, ribozymes, DNAzymes and nanozymes have been developed as enzyme mimics to accelerate this reaction. This review summarizes the progress in DNAzymes and nanozymes due to their excellent stability and low cost. We first introduce the structure and property of common porphyrins and metalloporphyrins. DNAzymes for porphyrin metalation are then reviewed, including early work, recent work using Pb2+ as a cofactor, and non-G-quadruplex DNAzymes. The catalytic mechanisms of DNAzymes are also discussed, especially the role of metal ions. Subsequently, nanozymes for porphyrin metalation based on graphene and a few other nanomaterials are reviewed. In this part, the interactions between the nanozymes and porphyrins are elucidated to describe the catalytic effect. In addition, beta-cyclodextrin and some surfactants that can form micelles in water were also found to have catalytic activity. Finally, we review the applications of porphyrin metalation reactions for the detection of various metal ions, improving photocatalytic activity, and removing heavy metal ions in water.

Graphical abstract: Porphyrin metalation catalyzed by DNAzymes and nanozymes

Article information

Article type
Review Article
Submitted
26 яну 2021
Accepted
02 мар 2021
First published
31 мар 2021

Inorg. Chem. Front., 2021,8, 2183-2199

Porphyrin metalation catalyzed by DNAzymes and nanozymes

H. Yang, Y. Zhou and J. Liu, Inorg. Chem. Front., 2021, 8, 2183 DOI: 10.1039/D1QI00105A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements