Issue 32, 2021

Current understanding of nanoparticle toxicity mechanisms and interactions with biological systems

Abstract

Nanotechnology is an emerging science involving the manipulation of matter on the nanometer scale. Nanoparticles (NPs) are engineered structures with at least one dimension of 100 nm or less. These materials are progressively being used for commercial purposes and being incorporated into everyday manufactured articles at an increasing rate. These products include consumer items such as pharmaceuticals, cosmetics, food, food packaging, and household products, among others. The same unique physical and chemical properties that make NPs so attractive may be associated with their potentially hazardous effects on cells and tissues. Despite the large benefit ensured from the application of nanotechnology, many issues related to NP behavior and adverse effects are not fully understood or should be examined anew. The traditional hypothesis that NPs exhibit different or additional hazards due to their “nano” size has been challenged in recent years, and NP categorization according to their properties and toxicity mechanism has been proposed instead. Possible undesirable results of these capabilities are harmful interactions with biological systems and the environment, with the potential to generate toxicity. Both in vivo and in vitro studies have shown that NPs are closely associated with toxicity by increasing intracellular reactive oxygen species (ROS) levels, and/or the levels of pro-inflammatory mediators. This review summarizes available data on NP toxicity in biological systems, with particular focus on oxidative stress and inflammation as the main mechanisms that lead to adverse health effects following NP exposure.

Graphical abstract: Current understanding of nanoparticle toxicity mechanisms and interactions with biological systems

Article information

Article type
Perspective
Submitted
22 мар 2021
Accepted
09 юли 2021
First published
09 юли 2021

New J. Chem., 2021,45, 14328-14344

Current understanding of nanoparticle toxicity mechanisms and interactions with biological systems

M. Garcés, L. Cáceres, D. Chiappetta, N. Magnani and P. Evelson, New J. Chem., 2021, 45, 14328 DOI: 10.1039/D1NJ01415C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements