Issue 10, 2020

Secondary modification of oxidatively-modified proline N-termini for the construction of complex bioconjugates

Abstract

A convenient two-step method is reported for the ligation of alkoxyamine- or hydrazine-bearing cargo to proline N-termini. Using this approach, bifunctional proline N-terminal bioconjugates are constructed and proline N-terminal proteins are immobilized.

Graphical abstract: Secondary modification of oxidatively-modified proline N-termini for the construction of complex bioconjugates

Supplementary files

Article information

Article type
Communication
Submitted
31 яну 2020
Accepted
06 фев 2020
First published
06 фев 2020

Org. Biomol. Chem., 2020,18, 1881-1885

Author version available

Secondary modification of oxidatively-modified proline N-termini for the construction of complex bioconjugates

J. C. Maza, A. V. Ramsey, M. Mehare, S. W. Krska, C. A. Parish and M. B. Francis, Org. Biomol. Chem., 2020, 18, 1881 DOI: 10.1039/D0OB00211A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements