Issue 13, 2020

Synthesis of chiral propargyl alcohols following the base-induced elimination protocol: application in the total synthesis of natural products

Abstract

Synthesis of enantiomerically pure propargyl alcohols is one of the most important tools in organic synthesis. Base-induced elimination of β-alkoxy chlorides could offer enantiomerically pure propargyl alcohols corresponding to their precursor. This protocol has been serving organic synthesis methods for three decades and has shown its enormous utility in the synthesis of a variety of natural products and small molecules. In this review, for the first time we compile the applications of the “base-induced elimination of β-alkoxy chlorides” protocol (BIEP) in the total synthesis of natural products. Furthermore, we discuss the scope and how this protocol could be a promising tool to generate propargyl alcohols.

Graphical abstract: Synthesis of chiral propargyl alcohols following the base-induced elimination protocol: application in the total synthesis of natural products

Article information

Article type
Perspective
Submitted
11 ное 2019
Accepted
14 фев 2020
First published
20 фев 2020

New J. Chem., 2020,44, 4972-4986

Synthesis of chiral propargyl alcohols following the base-induced elimination protocol: application in the total synthesis of natural products

U. M. Gonela and J. S. Yadav, New J. Chem., 2020, 44, 4972 DOI: 10.1039/C9NJ05626B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements