Issue 5, 2019

Detection of sulfadimethoxine using optical images of liquid crystals

Abstract

A label-free method for sulfadimethoxine (SDM) detection using an aptamer-based liquid crystal biosensor is developed. The sensor probe is fabricated by immobilizing amine-functionalized aptamers onto the glass slide decorating mixed self-assembled layers of triethoxysilylbutyraldehyde (TEA) and N,N-dimethyl-n-octadecyl-3-aminopropyltrimethoxysilylchloride (DMOAP). Liquid crystals (LCs) are supported on the surface and serve as response elements, which assume the homeotropic alignment and cause a dark optical appearance under crossed polarizers. In the presence of SDM, the formation of SDM–aptamer compounds induces a notable change in the topographical structure of the surface, which disturbs the original homeotropic orientation of LCs and results in a bright optical appearance. A detection limit of 10 μg L−1 is obtained, which is far lower than the maximum residue limit (100 μg L−1 in China). This facile method shows good specificity for SDM detection and may have great potential for detecting other small molecules.

Graphical abstract: Detection of sulfadimethoxine using optical images of liquid crystals

Supplementary files

Article information

Article type
Paper
Submitted
25 окт 2018
Accepted
28 дек 2018
First published
03 яну 2019

Analyst, 2019,144, 1761-1767

Detection of sulfadimethoxine using optical images of liquid crystals

J. Du, Q. Jiang, X. Lu, L. Chen, Y. Zhang and X. Xiong, Analyst, 2019, 144, 1761 DOI: 10.1039/C8AN02049C

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