Issue 7, 2018
From the journal:

Photochemical & Photobiological Sciences

Insulin hexamer dissociation dynamics revealed by photoinduced T-jumps and time-resolved X-ray solution scattering†

Dolev Rimmerman,a   Denis Leshchev,a   Darren J. Hsu,a   Jiyun Hong,a   Baxter Abraham,b   Irina Kosheleva,c   Robert Henningc  and  Lin X. Chen ORCID logo *ad  

* Corresponding authors

a Department of Chemistry, Northwestern University, Evanston, Illinois 60208, USA
E-mail: l-chen@northwestern.edu

b Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, USA

c Center for Advanced Radiation Sources, The University of Chicago, Illinois 60637, USA

d Chemical Sciences and Engineering Division, Argonne National Laboratory, Argonne, Illinois 60439, USA
E-mail: lchen@anl.gov

Abstract

The structural dynamics of insulin hexamer dissociation were studied by the photoinduced temperature jump technique and monitored by time-resolved X-ray scattering. The process of hexamer dissociation was found to involve several transient intermediates, including an expanded hexamer and an unstable tetramer. Our findings provide insights into the mechanisms of protien–protein association.

Graphical abstract: Insulin hexamer dissociation dynamics revealed by photoinduced T-jumps and time-resolved X-ray solution scattering

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C8PP00034D
Article type
Communication
Submitted
25 яну 2018
Accepted
24 май 2018
First published
25 май 2018

Photochem. Photobiol. Sci., 2018,17, 874-882

Author version available


Download author version (PDF)

Permissions

Request permissions

Insulin hexamer dissociation dynamics revealed by photoinduced T-jumps and time-resolved X-ray solution scattering

D. Rimmerman, D. Leshchev, D. J. Hsu, J. Hong, B. Abraham, I. Kosheleva, R. Henning and L. X. Chen, Photochem. Photobiol. Sci., 2018, 17, 874 DOI: 10.1039/C8PP00034D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements