An immunological electrospun scaffold for tumor cell killing and healthy tissue regeneration

Xingzhi Liu; Hongbo Zhang; Ruoyu Cheng; Yanzheng Gu; Yin Yin; Zhiyong Sun; Guoqing Pan; Zhongbin Deng; Huilin Yang; Lianfu Deng; Wenguo Cui; Hélder A. Santos; Qin Shi

doi:10.1039/C8MH00704G

An immunological electrospun scaffold for tumor cell killing and healthy tissue regeneration†

Xingzhi Liu,‡^a Hongbo Zhang,‡^bcdef Ruoyu Cheng,‡^a Yanzheng Gu,^a Yin Yin,^d Zhiyong Sun,^a Guoqing Pan,^a Zhongbin Deng,ⁱ Huilin Yang,^a Lianfu Deng,^bc Wenguo Cui,

*^bc Hélder A. Santos

*^gh and Qin Shi*^aj

Author affiliations

* Corresponding authors

^a Department of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute, Soochow University, 708 Renmin Road, Suzhou, Jiangsu 215006, P. R. China
E-mail: shiqin@suda.edu.cn

^b Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, P. R. China
E-mail: wgcui80@hotmail.com

^c State Key Laboratory of Molecular Engineering of Polymers, Fudan University, No. 220 Handan Road, Shanghai 200433, P. R. China

^d Animal Experimental Center, Soochow University, 99 Renai Road, Suzhou, Jiangsu, P. R. China

^e Department of Pharmaceutical Sciences Laboratory, Åbo Akademi University, Finland

^f Turku Center for Biotechnology, University of Turku and Åbo Akademi University, Finland

^g Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki FI-00014, Finland

^h Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki FI-00014, Finland
E-mail: helder.santos@helsinki.fi

ⁱ Department of Medicine, James Graham Brown Cancer Center, University of Louisville, 505 South Hancock Street, Louisville, KY 40202, USA

^j Key Laboratory of Stem Cells and Biomedical Materials of Jiangsu Province and Chinese Ministry of Science and Technology, 199 Renai Rd, Suzhou, China

Abstract

Antibody-based cancer immune therapy has attracted lots of research interest in recent years; however, it is greatly limited by the easy distribution and burst release of antibodies. In addition, after the clearance of the tissue, healthy tissue regeneration is another challenge for cancer treatment. Herein, we have developed a specific immunological tissue engineering scaffold using the agonistic mouse anti-human CD40 antibody (CD40mAb) incorporated into poly(L-lactide) (PLLA) electrospun fibers through the dopamine (PDA) motif (PLLA-PDA-CD40mAb). CD40mAb is successfully incorporated onto the surface of the electrospun fibrous scaffold, which is proved by immunofluorescence staining, and the PLLA-PDA-CD40mAb scaffold has an anti-tumor effect by locally releasing CD40mAb. Therefore, this immunological electrospun scaffold has very good potential to be developed as a powerful tool for localized tumor treatment, and this is the first to be reported in this area.

This article is part of the themed collection: Horizons Community Board Themed Collection – Nanobiomedicine

Materials Horizons

An immunological electrospun scaffold for tumor cell killing and healthy tissue regeneration†

Abstract

Supplementary files

Article information

Download Citation

Permissions

An immunological electrospun scaffold for tumor cell killing and healthy tissue regeneration

Social activity

Search articles by author

Spotlight

Advertisements