Asymmetric total synthesis of pleurospiroketals A and B†
Toyoharu
Kobayashi, 
a
Hideki
Abe
ab
and
a
Hideki
Abe
ab
and
Abstract
The first asymmetric total synthesis of pleurospiroketals A and B has been accomplished in 16 steps from 5-methyl-5-hexenoic acid. Key features of the synthesis are the highly syn-selective Evans aldol reaction, ring-closing metathesis, highly diastereoselective dihydroxylation and acid-mediated spiroketalization.
- This article is part of the themed collection: Natural product synthesis
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