Issue 69, 2018
From the journal:

Chemical Communications

Synthesis of new fluorinated proline analogues from polyfluoroalkyl β-ketoacetals and ethyl isocyanoacetate†‡

Nataliya A. Tolmachova,*a   Ivan S. Kondratov, ORCID logo ab   Violetta G. Dolovanyuk,b   Stanislav O. Pridma, ORCID logo a   Anton V. Chernykh,a   Constantin G. Daniliuc ORCID logo c  and  Günter Haufe ORCID logo *cd  

* Corresponding authors

a Enamine Ltd, Chervonotkatska Str. 78, Kyiv, Ukraine
E-mail: n.tolmachova@mail.enamine.net

b Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of Ukraine, Murmanska Str. 1, Kyiv, Ukraine

c Organisch-Chemisches Institut, Universität Münster, Corrensstraße 40, Münster 48149, Germany
E-mail: haufe@uni-muenster.de

d Cells-in-Motion Cluster of Excellence, Universität Münster, Waldeyerstraße 15, 48149 Münster, Germany

Abstract

The reaction of trifluoroaldol acetal and other polyfluoroalkyl β-ketoacetals with ethyl isocyanoacetate was applied for the preparation of hitherto unknown fluorinated amino acids, cis- and trans-3-CF3/C2F5-prolines as well as trans-3-CF2Br/CF2Cl/CHF2-3-hydroxyprolines.

Graphical abstract: Synthesis of new fluorinated proline analogues from polyfluoroalkyl β-ketoacetals and ethyl isocyanoacetate

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C8CC05912H
Article type
Communication
Submitted
20 юли 2018
Accepted
02 авг 2018
First published
02 авг 2018

Chem. Commun., 2018,54, 9683-9686

Permissions

Request permissions

Synthesis of new fluorinated proline analogues from polyfluoroalkyl β-ketoacetals and ethyl isocyanoacetate

N. A. Tolmachova, I. S. Kondratov, V. G. Dolovanyuk, S. O. Pridma, A. V. Chernykh, C. G. Daniliuc and G. Haufe, Chem. Commun., 2018, 54, 9683 DOI: 10.1039/C8CC05912H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements