Issue 69, 2018

Synthesis of new fluorinated proline analogues from polyfluoroalkyl β-ketoacetals and ethyl isocyanoacetate

Abstract

The reaction of trifluoroaldol acetal and other polyfluoroalkyl β-ketoacetals with ethyl isocyanoacetate was applied for the preparation of hitherto unknown fluorinated amino acids, cis- and trans-3-CF3/C2F5-prolines as well as trans-3-CF2Br/CF2Cl/CHF2-3-hydroxyprolines.

Graphical abstract: Synthesis of new fluorinated proline analogues from polyfluoroalkyl β-ketoacetals and ethyl isocyanoacetate

Supplementary files

Article information

Article type
Communication
Submitted
20 юли 2018
Accepted
02 авг 2018
First published
02 авг 2018

Chem. Commun., 2018,54, 9683-9686

Synthesis of new fluorinated proline analogues from polyfluoroalkyl β-ketoacetals and ethyl isocyanoacetate

N. A. Tolmachova, I. S. Kondratov, V. G. Dolovanyuk, S. O. Pridma, A. V. Chernykh, C. G. Daniliuc and G. Haufe, Chem. Commun., 2018, 54, 9683 DOI: 10.1039/C8CC05912H

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