Issue 12, 2015

Biocatalytic conversion of ethylene to ethylene oxide using an engineered toluene monooxygenase

Abstract

Mutants of toluene o-xylene monooxygenase are demonstrated to oxidize ethylene to ethylene oxide in vivo at yields of >99%. The best mutant increases ethylene oxidation activity by >5500-fold relative to the native enzyme. This is the first report of a recombinant enzyme capable of carrying out this industrially significant chemical conversion.

Graphical abstract: Biocatalytic conversion of ethylene to ethylene oxide using an engineered toluene monooxygenase

Supplementary files

Article information

Article type
Communication
Submitted
04 ное 2014
Accepted
12 дек 2014
First published
05 яну 2015

Chem. Commun., 2015,51, 2283-2285

Author version available

Biocatalytic conversion of ethylene to ethylene oxide using an engineered toluene monooxygenase

D. A. Carlin, S. J. Bertolani and J. B. Siegel, Chem. Commun., 2015, 51, 2283 DOI: 10.1039/C4CC08802F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements