Addition of CF3 across unsaturated moieties: a powerful functionalization tool
Abstract
In the last few years, the efficient introduction of trifluoromethyl groups in organic molecules has become a major research focus. This review highlights the recent developments enabling the incorporation of CF3 groups across unsaturated moieties, preferentially alkenes, and the mechanistic scenarios governing these transformations. We have specially focused on methods involving the simultaneous formation of C–CF3 and C–C or C–heteroatom bonds by formal addition reactions across π-systems, as such difunctionalization processes hold valuable synthetic potential.
- This article is part of the themed collections: Celebrating our 2019 Prize and Award winners, Celebrating the ChemSocRev Lectureship winners and Chem Soc Rev Emerging Investigators