Issue 26, 2009
From the journal:

Chemical Communications

Rhodium catalyzed enantioselective cyclization of substituted imidazolesvia C–H bond activation†‡

Andy S. Tsai,b   Rebecca M. Wilson,b   Hitoshi Harada,b   Robert G. Bergman*a  and  Jonathan A. Ellman*b  

* Corresponding authors

a Division of Chemical Sciences, Lawrence Berkeley National Laboratory and Department of Chemistry, University of California, Berkeley, USA
E-mail: rbergman@berkeley.edu
Fax: +1 510 642 7714
Tel: +1 510 642 2156

b Department of Chemistry, University of California, Berkeley, USA
E-mail: jellman@berkeley.edu
Fax: +1 510 666 2504
Tel: +1 510 642 4488

Abstract

The enantioselective intramolecular alkylation of substituted imidazoles with enantiomeric excesses up to 98% has been accomplished by rhodium catalyzed C–H bond functionalization with (S,S′,R,R′)TangPhos as the chiral ligand.

Graphical abstract: Rhodium catalyzed enantioselective cyclization of substituted imidazoles via C–H bond activation

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Article information

DOI
https://doi.org/10.1039/B902878A
Article type
Communication
Submitted
11 фев 2009
Accepted
01 май 2009
First published
02 юни 2009

Chem. Commun., 2009, 3910-3912

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Rhodium catalyzed enantioselective cyclization of substituted imidazoles via C–H bond activation

A. S. Tsai, R. M. Wilson, H. Harada, R. G. Bergman and J. A. Ellman, Chem. Commun., 2009, 3910 DOI: 10.1039/B902878A

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