Issue 35, 2020

A novel multifunctional FePt/BP nanoplatform for synergistic photothermal/photodynamic/chemodynamic cancer therapies and photothermally-enhanced immunotherapy

Abstract

A new multi-modal therapy agent, FePt/BP–PEI–FA nanoplatform, with FePt nanoparticles (FePt NPs) loaded onto ultrathin black phosphorus nanosheets (BPNs), has been constructed to enhance synergistic photothermal therapy (PTT), photodynamic therapy (PDT), and chemodynamic therapy (CDT) that target primary tumors. In this work, BPNs exhibit excellent photothermal and photodynamic behaviors under different wavelength laser irradiation. After polyethylenimine (PEI) modification, FePt NPs with sizes of 3–4 nm are uniformly attached onto the surface of modified BPNs via electrostatic adsorption. FePt NPs, as a ferroptosis agent, can transform endogenous H2O2 into reactive oxygen species (ROS) through the Fenton reaction, ultimately inducing cell death. Based on magnetic resonance imaging (MR) and thermal imaging, the as-prepared FePt/BP–PEI–FA NCs can inhibit tumor growth by achieving synergistic therapies. More significantly, combined with cytotoxic T lymphocyte-associated protein 4 (CTLA-4) checkpoint blockade, FePt/BP–PEI–FA NC-induced PTT can control both primary and untreated distant tumors’ growth. Therefore, FePt/BP–PEI–FA NCs is a potential multifunctional nanoagent for effective anti-tumor applications.

Graphical abstract: A novel multifunctional FePt/BP nanoplatform for synergistic photothermal/photodynamic/chemodynamic cancer therapies and photothermally-enhanced immunotherapy

Supplementary files

Article information

Article type
Paper
Submitted
14 фев 2020
Accepted
22 юли 2020
First published
23 юли 2020

J. Mater. Chem. B, 2020,8, 8010-8021

A novel multifunctional FePt/BP nanoplatform for synergistic photothermal/photodynamic/chemodynamic cancer therapies and photothermally-enhanced immunotherapy

X. Yao, B. Yang, S. Wang, Z. Dai, D. Zhang, X. Zheng and Q. Liu, J. Mater. Chem. B, 2020, 8, 8010 DOI: 10.1039/D0TB00411A

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