Issue 22, 2020

Transition metal complexes as imaging or therapeutic agents for neurodegenerative diseases

Abstract

Neurodegenerative diseases are the result of neurodegeneration, which is the process of losing neuronal functions gradually due to the irreversible damage and death of neurons. Metal complexes have attracted intense interest over recent decades as probes or inhibitors of biomolecules. In this review, we discuss the application of transition metal complexes in the diagnosis and therapy of different neurodegenerative diseases. We first briefly introduce conventional approaches for the diagnosis and treatment of neurodegenerative diseases. Then, the characteristics and mechanisms of transition metal complexes as luminescent probes and drug candidates are discussed. Representative examples of the use of metal complexes in targeted detection and treatment of neurodegenerative diseases are highlighted. Finally, the challenges and future perspectives of this field are presented.

Graphical abstract: Transition metal complexes as imaging or therapeutic agents for neurodegenerative diseases

Article information

Article type
Review Article
Submitted
26 ное 2019
Accepted
12 фев 2020
First published
12 фев 2020

J. Mater. Chem. B, 2020,8, 4715-4725

Transition metal complexes as imaging or therapeutic agents for neurodegenerative diseases

D. Ma, C. Wu, G. Li, T. Yung and C. Leung, J. Mater. Chem. B, 2020, 8, 4715 DOI: 10.1039/C9TB02669J

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