Issue 3, 2019

Tuning the properties of a cyclic RGD-containing tetrapeptide through backbone fluorination

Abstract

Stereoselective fluorination is investigated as a method for modulating the properties of a cyclic RGD-containing tetrapeptide. Three key outcomes of fluorination are assessed: (i) the effect on peptide cyclisation efficiency; (ii) the ability to fine-tune the molecular conformation; and (iii) the effect on the cyclic peptides’ biological activity. Fluorination is found to exert pronounced effects against all three criteria.

Graphical abstract: Tuning the properties of a cyclic RGD-containing tetrapeptide through backbone fluorination

Supplementary files

Article information

Article type
Paper
Submitted
30 окт 2018
Accepted
14 дек 2018
First published
14 дек 2018

Org. Biomol. Chem., 2019,17, 664-674

Tuning the properties of a cyclic RGD-containing tetrapeptide through backbone fluorination

C. Au, C. Gonzalez, Y. C. Leung, F. Mansour, J. Trinh, Z. Wang, X. Hu, R. Griffith, E. Pasquier and L. Hunter, Org. Biomol. Chem., 2019, 17, 664 DOI: 10.1039/C8OB02679C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements