Issue 30, 2019

Nonsteroidal anti-inflammatory drug metabolism studies in horses in view of doping control: analytical strategies and challenges

Abstract

Continuous research on metabolomics is of utmost importance in the field of anti-doping control, including updating the selection of the most appropriate markers of prohibited substances, test specimens and analytical strategies. Among metabolomics research topics, nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used in equine medicine and have a large diversity in their chemical structures; hence, their metabolism has been widely elucidated to construct appropriate anti-doping tests. This article provides an overview of the analytical methodologies used in anti-doping analysis and the metabolic research of NSAIDs concerning issues related to the use of alternative test matrices, sample preparation strategies and possible analytical techniques. In addition, the metabolic pathways of chosen NSAIDs in horses, associated analytical problems and future research directions are discussed.

Graphical abstract: Nonsteroidal anti-inflammatory drug metabolism studies in horses in view of doping control: analytical strategies and challenges

Article information

Article type
Critical Review
Submitted
02 апр 2019
Accepted
25 юни 2019
First published
01 юли 2019

Anal. Methods, 2019,11, 3767-3792

Nonsteroidal anti-inflammatory drug metabolism studies in horses in view of doping control: analytical strategies and challenges

E. Waraksa, W. Filipiak, E. Kłodzińska, M. Ozimek, M. Konop and J. Namieśnik, Anal. Methods, 2019, 11, 3767 DOI: 10.1039/C9AY00692C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements