Issue 45, 2018
From the journal:

Journal of Materials Chemistry B

Hyaluronic acid grafted nanoparticles of a platinum(ii)–silicon(iv) phthalocyanine conjugate for tumor and mitochondria-targeted photodynamic therapy in red light†

Koushambi Mitra, ORCID logo ab   Montserrat Samsó,c   Charles E. Lyonsb  and  Matthew C. T. Hartman ORCID logo *ab  

* Corresponding authors

a Department of Chemistry, Virginia Commonwealth University, 1001 West Main Street, P. O. Box 842006, Richmond, VA 23284, USA
E-mail: mchartman@vcu.edu

b Massey Cancer Center, Virginia Commonwealth University, 401 College Street, Richmond, VA 23298, USA

c Department of Physiology and Biophysics, 1101 E. Marshall St., Richmond, VA 23298, USA

Abstract

Herein, we report novel hyaluronic acid formulated nanoparticles containing a platinum(II) conjugated silicon(IV) phthalocyanine (SiPc–Pt–HA) for tumor targeted red light photodynamic therapy and chemotherapy. The SiPc–Pt–HA conjugate showed specific uptake, photo-enhanced cytotoxicity (∼1500 fold) and mitochondrial accumulation in breast cancer over normal cells.

Graphical abstract: Hyaluronic acid grafted nanoparticles of a platinum(ii)–silicon(iv) phthalocyanine conjugate for tumor and mitochondria-targeted photodynamic therapy in red light

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C8TB02533A
Article type
Communication
Submitted
26 сеп 2018
Accepted
15 окт 2018
First published
24 окт 2018

J. Mater. Chem. B, 2018,6, 7373-7377

Permissions

Request permissions

Hyaluronic acid grafted nanoparticles of a platinum(II)–silicon(IV) phthalocyanine conjugate for tumor and mitochondria-targeted photodynamic therapy in red light

K. Mitra, M. Samsó, C. E. Lyons and M. C. T. Hartman, J. Mater. Chem. B, 2018, 6, 7373 DOI: 10.1039/C8TB02533A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements