Issue 9, 2016

An unprecedented case of dodecamorphism: the twelfth polymorph of aripiprazole formed by seeding with its active metabolite

Abstract

A new polymorph of aripiprazole has been discovered, making it the most polymorphic drug to date with twelve reported anhydrous forms, and a record-breaking ninth solved crystal structure. The new form was induced by seeding with crystals of the active metabolite dehydro-aripiprazole.

Graphical abstract: An unprecedented case of dodecamorphism: the twelfth polymorph of aripiprazole formed by seeding with its active metabolite

Supplementary files

Article information

Article type
Communication
Submitted
16 дек 2015
Accepted
12 яну 2016
First published
13 яну 2016

CrystEngComm, 2016,18, 1486-1488

An unprecedented case of dodecamorphism: the twelfth polymorph of aripiprazole formed by seeding with its active metabolite

T. A. Zeidan, J. T. Trotta, P. A. Tilak, M. A. Oliveira, R. A. Chiarella, B. M. Foxman, Ö. Almarsson and M. B. Hickey, CrystEngComm, 2016, 18, 1486 DOI: 10.1039/C5CE02467F

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