Spiers Memorial Lecture

Spiers Memorial Lecture

Breeding and building molecular spies

X. Shu,^a V. Lev-Ram,^a E. S. Olson,^a T. A. Aguilera,^a T. Jiang,^a M. Whitney,^a J. L. Crisp,^a P. Steinbach,^a T. Deerinck,^b M. H. Ellisman,^b L. G. Ellies,^c Q. T. Nguyen^d and R. Y. Tsien^a

^a HHMI and Depts. Pharmacology, Univ. California, San Diego, USA

^b HHMI and Depts. Neuroscience, Univ. California, San Diego, USA

^c HHMI and Depts. Pathology, Univ. California, San Diego, USA

^d HHMI and Depts. Surgery, Univ. California, San Diego, USA

To circumvent the limited spatial resolution of fluorescent protein imaging, we are developing genetically encoded tags for electron microscopy (EM).