Cunzheng Fan, Nian Liu, Ningyuan Hu, Minghui Tong, Xuan Shi, Han Wang, Wenqiang Sun, Zehui Qi, Haoyu Zhang, Yixiang Sun, Zixuan Gao, Dongmei Zhao and Maosheng Cheng
RSC Med. Chem., 2025,16, 5717-5735
Abstract
Polo-like kinase 4 (PLK4), a member of the serine/threonine protein kinase family, serves as a central regulator of centriole duplication and plays a critical role in eukaryotic mitosis.
Yanli Xue, Shuyi Mu, Pengkun Sun, Yin Sun, Nian Liu, Yu Sun, Lin Wang, Dongmei Zhao and Maosheng Cheng
RSC Med. Chem., 2023,14, 1787-1802
Abstract
A structurally novel and highly efficient PLK4 inhibitor was synthesized.
Shuyi Mu, Wenqiang Sun, Zehui Qi, Minghui Tong, Xuan Shi, Han Wang, Nian Liu, Pengkun Sun, Cunzheng Fan, Ningyuan Hu, Yixiang Sun, Haoyu Zhang, Zixuan Gao, Dongmei Zhao and Maosheng Cheng
RSC Med. Chem., 2025,16, 4997-5011
Abstract
Serine/threonine kinase PLK4, a critical regulator of centrosome duplication, is closely associated with tumorigenesis due to its role in centrosome amplification.
Nian Liu, Xin Wang, Qinglin Fu, Qiaohua Qin, Tianxiao Wu, Ruicheng Lv, Dongmei Zhao and Maosheng Cheng
RSC Med. Chem., 2023,14, 85-102
Abstract
Based on scaffold hopping and computer-aid drug design, 38 pyrazolo[3,4-b]pyridine derivatives were synthesised. Among them, compound C03 showed acceptable activity with an IC50 value of 56 nM to TRKA kinase.
Jinwoo Shin, Nayeon Kang, Byungkook Kim, Hyunsik Hong, Le Yu, Jungryun Kim, Heemin Kang and Jong Seung Kim
Chem. Soc. Rev., 2023,52, 4488-4514
Abstract
This review summarizes a novel perspective on emerging 1-D nanomaterials for cancer therapy and diagnosis, highlighting the unique shape-dependent properties, recent advancements, and unexplored nanomaterial types and therapeutic applications.