This article covers the developments and outlook in auxiliary assisted C–H functionalization with vinylcyclopropanes and cyclopropanols utilizing transition-metal-catalysis.
A summary of the various ring opening reactions of strained and unstrained cycloalkanols is elaborated in the present review. Key emphasis on the reactivities pertaining to cyclopropanols, cyclobutanols and higher unstrained analogues is provided.
In this article, the synthesis of γ-keto sulfones over the period from 2020 to the present will be discussed, and the related reaction mechanisms will also be discussed.
A copper-catalyzed ring-opening trifluoromethylthiolation/trifluoromethylselenolation of cyclopropanols with ArSO2SCF3 or ArSO2SeCF3 is developed.
A flow-generated diazomethane method facilitates Pd-catalyzed cyclopropanation of vinylboronates, providing multigram access to stable 2-substituted cyclopropanols and rare ester-aldehydes via optimized mild-base oxidative hydrolysis in high yields.