This review summarizes the syntheses of ten representative families of natural products that contain tricyclic bridgehead carbon centers (TBCCs). We organize the approaches around the five strategies shown to aid future synthetic endeavors.
This review discusses the synthetic chemistry of huperzine A, a potent inhibitor of acetylcholine esterase (AChE), followed by the advancements in other alkaloids of the family. The analogs and medicinal chemistry of huperzines are summarized.
This review highlights modern uses of oxidative phenol coupling in the total synthesis of natural products, spanning catalytic, electrochemical, stoichiometric and enzymatic approaches.
This review covers all fungal terpenoid cyclases (TCs), including class I and II TCs as well as emerging UbiA-type TCs, together with their tailoring enzymes, focusing on newly identified TCs and tailoring enzymes from 2015 to August 2023.
This review highlights recent advances in the asymmetric synthesis of α-tertiary amine natural products via temporary chirality induction methods: Seebach's self-regeneration of stereocenters, C-to-N-to-C chirality transfer, and memory of chirality.