The Sonogashira coupling reaction of 2-(trimethylamino)methylindolyltriflates with aryl acetylenes followed by isomerization, thermal electrocyclization and 1,3-H shift to furnish the respective di- and tri-substituted carbazoles.
In this study, a series of 12 novel pyrrolyl chalcones and 22 pyrrole-fused pyrimidine derivatives were synthesized with good yields.
Suzuki–Miyaura cross-coupling, density functional theory, and auto-docking investigations were used to determine the effectiveness and stability of indazole derivatives.
Alzheimer's disease (AD) is a multifactorial irreversible neurological disorder with multiple enzymes involved.
Illustration of the synthesis of 1,2,3-triazole-nicotinonitrile derivatives.