Experimental and computational studies revealed the crucial role of HFIP in regioselectivity-switchable bromolactonization reactions, with the formation of endo-products under kinetic control and exo-products under thermodynamic control.
Recent advances in chiral sulfide-catalyzed asymmetric halocyclizations are summarized.
We developed a novel thiourea Lewis-base catalyst with phenol moieties for the enantioselective 5-exo-bromolactonization of stilbenecarboxylic acids to afford chiral 3-substituted phthalides.
In this study, a catalyst-free and highly efficient approach to access seven types of small-sized, medium-sized, and large-sized heterocyclic units via halocyclization was developed, leveraging the use of suitable preorganization by the ICDA model.
Heteroatom-substituted axially chiral allenes represent an important subclass of chiral allenes. We summarizes the contributions on heteroatom-substituted axially chiral allenes and their catalytic asymmetric synthesis and synthetic applications.