A novel amine oxidase from Vibrio sp. JCM 19236 was obtained by gene mining and its mutants were obtained by protein engineering for efficient oxidative dehydroaromatization of 1,2,3,4-tetrahydroquinolines toward quinolines under mild conditions.
The advances in the Povarov reactions under visible-light conditions are highlighted, offering helpful guidance for selecting suitable synthetic protocols.
Hexafluoroisopropanol (HFIP)-mediated one-pot tandem reduction of quinolines to tetrahydroquinolines followed by reductive alkylation by the aldehyde has been demonstrated through H-bonding network-enabled substrate activation.
An efficient biocatalytic approach for the oxidative dehydroaromatization of 1,2,3,4-tetrahydroquinolines by employing a monoamine oxidase PpMAO with molecular oxygen under mild conditions.
We successfully explored a one-pot strategy to synthesize valuable chiral 2-functionalized tetrahydroquinoline motifs through the precise modification of amides derived from commercially available natural amino acids.