The unprecedented alkylation of quinoxalinones with electron-deficient alkenes has been realized by a sequential paired electrolysis.
A protocol of photodriven, TFA-mediated oxidative coupling of quinoxalinones with 5-pyrazolones has been realized under air, and mechanistic research confirmed that radical and ionic pathways exist. A visible-light-catalyzed method was first used.
TFA-catalyzed C(3)–H alkenylation of quinoxalin-2(1H)-ones with Hantzsch esters yielded new molecular entities exhibiting promising in silico biological activities.
A novel quinoxalinone-functionalized A–D–A type DTE is developed. Its protonated derivative displays an unprecedented green light-triggered NIR II photochromism in the presence of TFA, which is the first case of NIR II photochromic DTE.
Photocatalytic C–S bond activation in cysteine derivatives with quinoxalinones for the synthesis of pharmacologically interesting heteroaryl amino acids was developed.