The unprecedented alkylation of quinoxalinones with electron-deficient alkenes has been realized by a sequential paired electrolysis.
An efficient protocol for the C3-homocoupling reaction of quinoxalinones with potassium tert-butoxide is described. The detailed mechanistic pathway on the single electron transfer (SET) process has been proposed.
The mechanism for the photoredox catalysed synthesis of triazoloquinoxalinones is unveiled by DFT calculations. Predictive chemistry gives the recipe of substituents, sterically and electronically, can fit to perform the reaction at room temperature.
A protocol of photodriven, TFA-mediated oxidative coupling of quinoxalinones with 5-pyrazolones has been realized under air, and mechanistic research confirmed that radical and ionic pathways exist. A visible-light-catalyzed method was first used.
Photocatalytic C–S bond activation in cysteine derivatives with quinoxalinones for the synthesis of pharmacologically interesting heteroaryl amino acids was developed.