Electrophilic azetidinylation reagents enable efficient, “any-stage” installation of azetidine rings onto nucleophiles, providing modular access to 3,3-disubstituted azetidines for drug development.
Subjecting 2,2-disubstituted azetidines to amide coupling with carboxylic acids is found to effect either N-acylation or ring expansion to spiro- and 6,6-disubstituted 5,6-dihydro-4H-1,3-oxazines, dependent on the reaction conditions.
This review aims to provide an overview of the biosyntheses of the striking azetidine-containing natural products, with an emphasis on the biosynthetic mechanisms of naturally occurring azetidines.
This paper presents a mild and efficient dual copper/photoredox-catalyzed multi-component allylation of azabicyclo[1.1.0]butanes using a radical-relay strategy.
Heterocycles consisting nitrogen are a potent bioactive compounds, that have extensive application in agrochemistry, materials research, and medicinal chemistry. An overview of the synthesis of N-heterocycles using visible-light photoredox catalysis has been provided in this article.