A summary of the various ring opening reactions of strained and unstrained cycloalkanols is elaborated in the present review. Key emphasis on the reactivities pertaining to cyclopropanols, cyclobutanols and higher unstrained analogues is provided.
A straightforward method for the synthesis of nitrocyclobutene derivatives from cyclobutanols with Fe(NO3)3·9H2O has been developed via a visible-light photocatalytic radical addition reaction.
A visible-light-mediated tandem ring opening/1,6-conjugate addition of cyclobutanols with p-quinone methides was developed. This protocol allowed the formation of δ,δ-diaryl ketones in the presence of a readily available organic photocatalyst.
Aqueous-phase trifunctionalization of [1.1.1]propellane enables direct access to diverse 3,3-disubstituted cyclobutanols under mild conditions.
Ring-opening oxyimidation of cyclobutanols and cyclopropanols with the formation of ω-functionalized ketones via radical cross-recombination is reported.