A steric-hindrance regulated probe NBD-2FDCI for self-adaptive detection of biothiols and H2S in human urine and living cells.
Biothiols, such as cysteine (Cys), glutathione (GSH), and homocysteine (Hcy), play crucial roles in various physiological processes and serve as biomarkers for oxidative stress and redox homeostasis.
A novel chemosensor (P1) based on pyranopyrazole has been developed for the specific detection of biothiols. P1 has excellent sensing capability throughout a broad pH range, guaranteeing its adaptability in diverse biological settings.
Biomolecules play vital roles in many biological processes and diseases, making their identification crucial.
Cysteine (Cys), homocysteine (Hcy), and glutathione (GSH) share similar functional groups, such as thiol (–SH) and amino (–NH2), but differ in their spatial structures.