In this work, we report a regioselective sulfonamidation of N-(2-hydroxyaryl)amides with iminoiodinanes and iodine in visible light at room temperature.
This study developed novel progesterone-based CDK8 inhibitors and demonstrated their anticancer activity against A549 cells in CS-PEG nanoform, supported by gene expression analysis, CDK8 inhibition, and molecular docking studies.
Discovery of new PIM-1 inhibitors with the 4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile scaffold with S-arylamide hybrids.
The impact of cyclometalating ligands on the photophysical behaviour of heteroleptic Ir(III) complexes with imidazo[4,5-f][1,10]phenanthroline. [Ir(ppy)2(imphen)]+ is a 3MLLCT emitter, while [Ir(pybzth)2(imphen)]+ has a predominant 3LCN∩C character.
A bioinspired Co(III) catalyst efficiently transforms epoxides and CO2 into cyclic carbonates. The mechanism was found to combine the cooperative effects of the metal center and amino acid residues in the outer coordination sphere.