Recent advances in [4 + 4] annulation of conjugated heterodienes with 1,4-dipolar species for the synthesis of eight-membered heterocycles

Yahui Wang, Zefeng Jin, Liejin Zhou and Xin Lv

Org. Biomol. Chem., 2024, 22, 252
DOI: 10.1039/D3OB01626A

Asymmetric [3 + 2] cycloaddition of donor–acceptor cyclopropanes with azadienes enabled by Brønsted base catalysis

Shu Li, Zhi-Hong Dong, Si-Yu Dan, Mei-Jun Zheng, Teng Long, Jie Zhan, Qing Zhou, Wen-Dao Chu and Quan-Zhong Liu

Org. Chem. Front., 2024, 11, 2905
DOI: 10.1039/D4QO00002A

Elucidating the mechanism and origin of diastereoselectivity in scandium-catalyzed β-C(sp3)–H activation and transformation of an aliphatic aldimine

Yiran Zhang and Yang Wang

Org. Chem. Front., 2024, 11, 4391
DOI: 10.1039/D4QO00567H

Transition-metal-free regioselective synthesis of spiro-oxazolidines through [3 + 2] annulation reactions of azadienes with haloalcohols

Amol T. Savekar, Sonali M. Vitnor, Vishal B. Karande and Suresh B. Waghmode

RSC Adv., 2025, 15, 10634
DOI: 10.1039/D5RA01423A

Theoretical insight into the mechanism, selectivity, and substituent effects in Rh-catalyzed asymmetric arylation of cyclobutenone ketals with arylboronic acids

Jinzhao Wang, Qiang Zhang, Li Jiang, Rongxiu Zhu and Dongju Zhang

Org. Chem. Front., 2026, 13, 2782
DOI: 10.1039/D6QO00087H

Transition metal-free efficient synthesis of bis(indolyl)propynes (BIPs)

Anjali Chaturvedi, Vishal Sharma, Fathimath Nafla CM, Katikam SivaPrasad, Deepak Sharma, Nikhil Kumar, Rushal Chandel, Manpreet Singh, Ravindra K. Rawal and Virender Singh

Org. Biomol. Chem., 2024, 22, 7039
DOI: 10.1039/D4OB01017E

Unveiling the role of water in the coupling of pyrroles and isocyanates to amidopyrroles inside a hexameric resorcinarene capsule

Sanat Kumar Mahapatra, Bijoy Ghosh and Lisa Roy

Phys. Chem. Chem. Phys., 2026, 28, 9193
DOI: 10.1039/D5CP01713K

Asymmetric Organocatalytic Diels–Alder Reaction of Olefinic Azlactones with Unsaturated Thiazolones: Access to Spirocyclohexenone Thiazolone Skeletons

Zahid Ahmad Khan and Vinod K. Singh

J. Org. Chem., 2024, 89, 15271
DOI: 10.1021/acs.joc.4c02088

Organocatalytic Asymmetric [4 + 4] Annulation Reaction of Ynones with Unsaturated Pyrazolones: Synthesis of Eight-Membered Ether-Embedded 4,5-Fused Pyrazoles

Dipankar Barman and Subhas Chandra Pan

Org. Lett., 2025, 27, 5338
DOI: 10.1021/acs.orglett.5c01118

BF3·Et2O‐Promoted Annulation of 2‐Propynolphenols With Thiophenols to Yield 2‐Substituted 3‐Sulfenylbenzofurans With Anti‐Prostate Cancer Activities

Lin Shi, Pengyu Liang, Zhou Sun, Liangchen Xie, Ruoxuan Sun, Na Zhao, LiZeng Peng and Xiaojun Yao

Asian J Org Chem, 2026, 15
DOI: 10.1002/ajoc.70268

Application of Indolyl Ynones in the Construction of Chiral Carbazoles and Pyrroloindolines by Organo and Metal Sequential Catalysis

Qing-Qing Li, Qian-Jun Lin, Yi Gao, Wen-Jing Xiao, Xue-Qing Song, Longfei Li, Wan Li, Ya-Li Song and Zhi-Hao You

Org. Lett., 2025, 27, 6216
DOI: 10.1021/acs.orglett.5c01900

Phosphine-catalyzed [3 + 2]-annulation of Morita–Baylis–Hillman carbonates with benzofuran-derived azadienes: Synthesis of spiro-cyclopentane benzofurans

Wanxing Liu, Yandong Lv, Xiuzheng Liu, Menghui Guo, Rui Yan, Lingang Wu, Lei Xie and Zhaoxue Wang

Tetrahedron, 2025, 182, 134703
DOI: 10.1016/j.tet.2025.134703

Spiro-Annulation of Ene-diones with Iodonium Ylides: An Anomalous Cloke–Wilson Rearrangement for the Regioselective Synthesis of Spirodihydrobenzofurans

Basit Qayoom, Auqib Rashid, Gowhar Ahmad Rather, Haamid R. Bhat, Bilal A. Bhat and Showkat Rashid

J. Org. Chem., 2026, 91, 3950
DOI: 10.1021/acs.joc.5c02651

Organocatalytic Regio‐ and Enantioselective Friedel‐Crafts Alkylation of N‐Aryl Anilines with Aurone‐Derived Azadienes: Access to Benzofuran Embedded Triarylmethanes

Rupkumar Khuntia, Subhrajit Karmakar, Koyal Roy, Kalishankar Bhattacharyya and Subhas Chandra Pan

Chemistry An Asian Journal, 2025, 20
DOI: 10.1002/asia.202500722

Conditions-Controlled Divergent Annulation of Bicyclo[1.1.0]butanes and Dioxopyrrolidines through Lewis Acid Catalysis

Jun-Long Li, Chuan Xie, Rong Zeng, Wen-Chao Yuan, Yuan-Yuan Lei, Ting Qi, Hai-Jun Leng and Qing-Zhu Li

ACS Catal., 2025, 15, 6025
DOI: 10.1021/acscatal.4c07205

Efficient Metal-Free Synthesis of Heterotriarylmethanes by 1,4-Addition of Benzofuran Azadienes

Hong-Li Huang, Shan Li, Yong-Zheng Lv, Ya-Qian Shi, Chang-Bo Liu, Zhongzhong Peng and Fei Gao

Synlett, 2025, 36, 484
DOI: 10.1055/a-2370-6462

Highly Enantioselective Construction of Chiral Eight-Membered Cyclic Ethers through Tandem Cyclization of Ynones and Dicarbonyl Compounds

Yuzhen Chen, Peishan Gu, Jialiang Qin, Huicai Huang and Yongbo Xue

J. Org. Chem., 2024, 89, 16736
DOI: 10.1021/acs.joc.4c02034

Harnessing Selectivity and Reactivity with Noncovalent Interactions in Molecular and Supramolecular Organo‐Catalysis: A Computational Perspective

Sanat Kumar Mahapatra, Bijoy Ghosh and Lisa Roy

ChemCatChem, 2025, 17
DOI: 10.1002/cctc.202501069

Microwave-Assisted Palladium-Catalyzed Crossover-Annulation: Access to Fused Polycyclic Benzofuran Scaffolds

Komal Goel and Gedu Satyanarayana

Org. Lett., 2025, 27, 80
DOI: 10.1021/acs.orglett.4c03917

Synthesis, characterization and theoretical investigations of the newly developed molecular salts of an anti-psychotic drug (Penfluridol)

Gowtham Kenguva, Smruti Rekha Rout, Ananya Kar, Lopamudra Giri, Sanat Kumar Mahapatra, Tabrez R. Shaikh, Debjani Baidya, Nikita Shelke and Rambabu Dandela

Journal of Molecular Structure, 2025, 1328, 141392
DOI: 10.1016/j.molstruc.2025.141392

Copper-Catalyzed Enantioselective 1,2-Allylation of Azadienes with Allylboronates

Zhi-Hong Dong, Shu Li, Teng Long, Jie Zhan, Cheng-kai Ruan, Xu Yan, Wen-Dao Chu, Kun Yuan and Quan-Zhong Liu

Org. Lett., 2024, 26, 3235
DOI: 10.1021/acs.orglett.4c00869

Photoinduced Regiodivergent and Enantioselective Cross-Coupling of Glycine Derivatives with Hydrocarbon Feedstocks

Fuxing Yang, Longxiao Chi, Ziqi Ye and Lei Gong

J. Am. Chem. Soc., 2025, 147, 1767
DOI: 10.1021/jacs.4c13321