Noncancerous disease-targeting AIEgens

Yanhong Duo, Guanghong Luo, Wentao Zhang, Renzhi Wang, Gary Guishan Xiao, Zihuang Li, Xianming Li, Meili Chen, Juyoung Yoon and Ben Zhong Tang

Chem. Soc. Rev., 2023, 52, 1024
DOI: 10.1039/D2CS00610C

The fast-growing field of photo-driven theranostics based on aggregation-induced emission

Zhijun Zhang, Miaomiao Kang, Hui Tan, Nan Song, Meng Li, Peihong Xiao, Dingyuan Yan, Liping Zhang, Dong Wang and Ben Zhong Tang

Chem. Soc. Rev., 2022, 51, 1983
DOI: 10.1039/D1CS01138C

A novel AIEgen photosensitizer with an elevated intersystem crossing rate for tumor precise imaging and therapy

Yingcai Hu, Sheng-Yan Yin, Zuhao Li, Wenchen Qi, Yun Chen and Jishan Li

Chem. Commun., 2022, 58, 13143
DOI: 10.1039/D2CC05313F

A review of AIE-based theranostic strategies regarding antibiotic-tolerant microbial infections

Tun Sun, Jiayi Song, Wentian Zhang, Linjie Tan, Junfeng Dong and Ying Li

Chem. Commun., 2025, 61, 17751
DOI: 10.1039/D5CC04510J

Development of organic photosensitizers for antimicrobial photodynamic therapy

Wenya Zhou, Xiqun Jiang and Xu Zhen

Biomater. Sci., 2023, 11, 5108
DOI: 10.1039/D3BM00730H

Visualizing intracellular dynamics with AIE probes

Michelle M. S. Lee, Eric Y. Yu, Joe H. C. Chau, Jacky W. Y. Lam, Ryan T. K. Kwok, Dong Wang and Ben Zhong Tang

Mater. Chem. Front., 2023, 7, 2973
DOI: 10.1039/D2QM01382G

Recent progress of aggregation-induced emission luminogens (AIEgens) for bacterial detection and theranostics

Xuping Feng, Bin Tong, Jianbing Shi, Changsheng Zhao, Zhengxu Cai and Yuping Dong

Mater. Chem. Front., 2021, 5, 1164
DOI: 10.1039/D0QM00753F

Small-molecule fluorescent probes: big future for specific bacterial labeling and infection detection

Zhimin Wang and Bengang Xing

Chem. Commun., 2022, 58, 155
DOI: 10.1039/D1CC05531C

Ellagic acid-modified gold nanoparticles to combat multi-drug resistant bacterial infections in vitro and in vivo

Yaran Wang, Fan Wu, Yuanfeng Li, Siran Wang, Yijin Ren, Linqi Shi, Henny C. van der Mei and Yong Liu

Mater. Horiz., 2024, 11, 4781
DOI: 10.1039/D4MH00642A

Metabolic labeling of peptidoglycan enabled optical analysis of probiotic vitality

Xinping Hu, Qirong Xiong, Shuai Hou and Hongwei Duan

Anal. Methods, 2024, 16, 6164
DOI: 10.1039/D4AY00982G

A coumarin-based fluorescent probe for NIR imaging-guided photodynamic therapy against S. aureus-induced infection in mouse models

Jun Li, Le Tu, Qingying Ouyang, Sheng-gang Yang, Xiao Liu, Qianqian Zhai, Yao Sun, Juyoung Yoon and Huailong Teng

J. Mater. Chem. B, 2022, 10, 1427
DOI: 10.1039/D1TB02723A

One-step light-up metabolic probes for in situ discrimination and killing of intracellular bacteria

Eric Y. Yu, Michelle M. S. Lee, Joe H. C. Chau, Kristy W. K. Lam, Hojeong Park, Ryan T. K. Kwok, Jacky W. Y. Lam, Yuanyuan Li and Ben Zhong Tang

Mater. Chem. Front., 2022, 6, 450
DOI: 10.1039/D1QM01495A

Recent advances of AIE light-up probes for photodynamic therapy

Shanshan Liu, Guangxue Feng, Ben Zhong Tang and Bin Liu

Chem. Sci., 2021, 12, 6488
DOI: 10.1039/D1SC00045D

Acid‐Responsive Nanoporphyrin Evolution for Near‐Infrared Fluorescence‐Guided Photo‐Ablation of Biofilm

Mengyao Yang, Zulal Özdemir, Heejeong Kim, Sanghee Nah, Erik Andris, Xingshu Li, Zdeněk Wimmer and Juyoung Yoon

Adv Healthcare Materials, 2022, 11
DOI: 10.1002/adhm.202200529

Photodynamic therapy empowered by nanotechnology for oral and dental science: Progress and perspectives

Lei-Lei Yang, Hangshuo Li, Danfeng Liu, Kaiyuan Li, Songya Li, Yuhan Li, Pengxi Du, Miaochen Yan, Yi Zhang and Wei He

Nanotechnology Reviews, 2023, 12
DOI: 10.1515/ntrev-2023-0163

Cationic conjugated polymers with tunable hydrophobicity for efficient treatment of multidrug-resistant wound biofilm infections

Ahmed Nabawy, Aritra Nath Chattopadhyay, Jessa Marie V. Makabenta, Muhammad Aamir Hassan, Junwhee Yang, Jungmi Park, Mingdi Jiang, Taewon Jeon, Jungkyun Im and Vincent M. Rotello

Biomaterials, 2025, 316, 123015
DOI: 10.1016/j.biomaterials.2024.123015

Emerging trends in aggregation induced emissive luminogens as bacterial theranostics

Rashmi Kumari and Dhanya Sunil

Journal of Drug Targeting, 2021, 29, 793
DOI: 10.1080/1061186X.2021.1888111

Bacterial DNA‐Targeting AIE Photosensitizer for Efficient Eradication of Intracellular Bacteria and Biofilm‐Associated Infections

Yonghui Lv, Minyang Zhao, Qiaowen Lin, Zhiwen Xu, Qingqing Bai, Dan Ding, Duo Mao and Kang‐Nan Wang

Aggregate, 2025, 6
DOI: 10.1002/agt2.70214

AIEgens for microorganism‐related visualization and therapy

Ziyue Ye, Wei He, Zicong Zhang, Zijie Qiu, Zheng Zhao and Ben Zhong Tang

Interdisciplinary Medicine, 2023, 1
DOI: 10.1002/INMD.20220011

Imitation-mussel fluorescent silicon quantum dots for selective labeling and imaging of bacteria and biofilms

Jiayi Lin, Linlin Xu, Yuling Zheng, Dalin Wu and Jun Yue

Front. Bioeng. Biotechnol., 2022, 10
DOI: 10.3389/fbioe.2022.971682

In vivo Labeling and Intravital Imaging of Bacterial Infection using a Near‐infrared Fluorescent D‐Amino Acid Probe

Yixuan Li, Yingjun Zhou, Yahui Du, Po Gao, Liqun Yang and Wei Wang

ChemBioChem, 2024, 25
DOI: 10.1002/cbic.202400283

Development and Applications of D‐Amino Acid Derivatives‐based Metabolic Labeling of Bacterial Peptidoglycan

Yongfang Zheng, Xinyu Zhu, Mingyi Jiang, Fangfang Cao, Qing You and Xiaoyuan Chen

Angew Chem Int Ed, 2024, 63
DOI: 10.1002/anie.202319400

Structure and functions of Aggregation-Induced Emission-Photosensitizers in anticancer and antimicrobial theranostics

Heidi Abrahamse, Michael R. Hamblin and Sajan George

Front. Chem., 2022, 10
DOI: 10.3389/fchem.2022.984268

A Highly Efficient Aggregation-induced Emission Photosensitizer for Photodynamic Combat of Multidrug-resistant Bacteria

Qian Zou, Jia-Li Wang, Ming-Yu Wu, Chuen Kam, Sin-Ying Lee, Shun Feng and Sijie Chen

Chem. Res. Chin. Univ., 2021, 37, 150
DOI: 10.1007/s40242-021-0393-2

Engineering molecular theranostic probes for antibacterial therapy

Xiaoyu Wang, Jiankang Gong, Jiaxuan Wang, Fan Zhang, Zhiqiang Mao and Zhihong Liu

TrAC Trends in Analytical Chemistry, 2023, 167, 117232
DOI: 10.1016/j.trac.2023.117232

D-Alanine functionalized Iridium(III) complexes as two-photon photo-antibiotics for bacteria-specific ablation in infected macrophages

Jun Shu, Hui Jiang, Minwei Lin, Jinzhe Liang, Yukun Zhao, Diqing Luo, Jinquan Wang and Hui Chao

European Journal of Medicinal Chemistry, 2025, 294, 117758
DOI: 10.1016/j.ejmech.2025.117758

Aggregation‐enhanced theranostics: AIE sparkles in biomedical field

Miaomiao Kang, Zhijun Zhang, Nan Song, Meng Li, Panpan Sun, Xiaohui Chen, Dong Wang and Ben Zhong Tang

Aggregate, 2020, 1, 80
DOI: 10.1002/agt2.7

Multi‐Channel Optical Device for Solar‐Driven Bacterial Inactivation under Real‐Time Temperature Feedback

Xianquan Liao, Yuxin Liu, Qi Jia and Jing Zhou

Chemistry A European J, 2021, 27, 11094
DOI: 10.1002/chem.202101458

Carboxyl group-decorated polythiophenes polymeric PBTE-T-COOH for visible-light-driven photocatalytic drug-resistant bacteria inactivation

Yingli Bi, Diyang Shan, Bo Feng, Simiao Wang, Enwei Zhu, Haiyong Guo, Jiankang Yu, Chunbo Liu and Juan Du

Materials Today Communications, 2023, 34, 105148
DOI: 10.1016/j.mtcomm.2022.105148

Peptide‐Engineered AIE Nanofibers with Excellent and Precisely Adjustable Antibacterial Activity

Kunzhong Guo, Minjie Zhang, Junyi Cai, Zunwei Ma, Zhou Fang, Haiyan Zhou, Junjian Chen, Meng Gao and Lin Wang

Small, 2022, 18
DOI: 10.1002/smll.202108030

AIE Photosensitizer with Tuned Membrane Interactions for Effective-Gram-Negative Bacteria Elimination

Edward Kamya, Shangzhao Yi, Zhongzhong Lu, Jincong Yan, Hewan Dawit, Shah Mehmood, Yi Cao and Renjun Pei

Bioconjugate Chem., 2025, 36, 881
DOI: 10.1021/acs.bioconjchem.5c00132

Aggregation‐Induced Emission‐Based Platforms for the Treatment of Bacteria, Fungi, and Viruses

Xiaohui Chen, Haijie Han, Zhe Tang, Qiao Jin and Jian Ji

Adv Healthcare Materials, 2021, 10
DOI: 10.1002/adhm.202100736

AIEgen-biomacromolecule conjugates: Visualized delivery and light-controlled theranostic platforms

Siqin Chen, Bowen Li and Bin Liu

Journal of Controlled Release, 2025, 378, 605
DOI: 10.1016/j.jconrel.2024.12.047

Light‐Activated Nanocatalyst for Precise In‐Situ Antimicrobial Synthesis via Photoredox‐Catalytic Click Reaction

Minyang Zhao, Lei Cao, Qingqing Bai, Yaru Lu, Bowen Li, Wenbo Wu, Jinzhou Ye, Xinhan Chen, Zhihong Wang, Bin Liu and Duo Mao

Angew Chem Int Ed, 2024, 63
DOI: 10.1002/anie.202408918

Aggregation-induced emission shining in the biomedical field: From bench to bedside

Yishen Liu, Qingrong Chen, Yidan Sun, Luojia Chen, Yuncong Yuan and Meijia Gu

Engineered Regeneration, 2021, 2, 206
DOI: 10.1016/j.engreg.2021.11.001

AIEgen-Based Nanomaterials for Bacterial Imaging and Antimicrobial Applications: Recent Advances and Perspectives

Zipeng Shen, Yinzhen Pan, Dingyuan Yan, Dong Wang and Ben Zhong Tang

Molecules, 2023, 28, 2863
DOI: 10.3390/molecules28062863

Aggregation-Induced Emission (AIE), Life and Health

Haoran Wang, Qiyao Li, Parvej Alam, Haotian Bai, Vandana Bhalla, Martin R. Bryce, Mingyue Cao, Chao Chen, Sijie Chen, Xirui Chen, Yuncong Chen, Zhijun Chen, Dongfeng Dang, Dan Ding, Siyang Ding, Yanhong Duo, Meng Gao, Wei He, Xuewen He, Xuechuan Hong, Yuning Hong, Jing-Jing Hu, Rong Hu, Xiaolin Huang, Tony D. James, Xingyu Jiang, Gen-ichi Konishi, Ryan T. K. Kwok, Jacky W. Y. Lam, Chunbin Li, Haidong Li, Kai Li, Nan Li, Wei-Jian Li, Ying Li, Xing-Jie Liang, Yongye Liang, Bin Liu, Guozhen Liu, Xingang Liu, Xiaoding Lou, Xin-Yue Lou, Liang Luo, Paul R. McGonigal, Zong-Wan Mao, Guangle Niu, Tze Cin Owyong, Andrea Pucci, Jun Qian, Anjun Qin, Zijie Qiu, Andrey L. Rogach, Bo Situ, Kazuo Tanaka, Youhong Tang, Bingnan Wang, Dong Wang, Jianguo Wang, Wei Wang, Wen-Xiong Wang, Wen-Jin Wang, Xinyuan Wang, Yi-Feng Wang, Shuizhu Wu, Yifan Wu, Yonghua Xiong, Ruohan Xu, Chenxu Yan, Saisai Yan, Hai-Bo Yang, Lin-Lin Yang, Mingwang Yang, Ying-Wei Yang, Juyoung Yoon, Shuang-Quan Zang, Jiangjiang Zhang, Pengfei Zhang, Tianfu Zhang, Xin Zhang, Xin Zhang, Na Zhao, Zheng Zhao, Jie Zheng, Lei Zheng, Zheng Zheng, Ming-Qiang Zhu, Wei-Hong Zhu, Hang Zou and Ben Zhong Tang

ACS Nano, 2023, 17, 14347
DOI: 10.1021/acsnano.3c03925

Cancer‐Cell‐Activated in situ Synthesis of Mitochondria‐Targeting AIE Photosensitizer for Precise Photodynamic Therapy

Yuanbo Wang, Shidang Xu, Leilei Shi, Cathleen Teh, Guobin Qi and Bin Liu

Angew Chem Int Ed, 2021, 60, 14945
DOI: 10.1002/anie.202017350

Cetyltrimethylammonium-chloride assisted in situ metabolic incorporation of nano-sized ROS-generating cascade-reaction containers in Gram-positive and Gram-negative peptidoglycan layers for the control of bacterially-induced sepsis

Guang Yang, Da-Yuan Wang, Jianwen Song, Yijin Ren, Yingli An, Henk J. Busscher, Henny C. van der Mei and Linqi Shi

Acta Biomaterialia, 2024, 181, 347
DOI: 10.1016/j.actbio.2024.04.045

Cancer‐Cell‐Activated in situ Synthesis of Mitochondria‐Targeting AIE Photosensitizer for Precise Photodynamic Therapy

Yuanbo Wang, Shidang Xu, Leilei Shi, Cathleen Teh, Guobin Qi and Bin Liu

Angewandte Chemie, 2021, 133, 15072
DOI: 10.1002/ange.202017350

Metabolism‐Driven Disassembly of Nanoprobes for Bacterial Detection, Imaging, and Photo‐Inactivation

Wei Zhao, Meng Ding, Xu Zhang, Zhirong Xin, Lingjie Song, Ziyong Cheng and Shifang Luan

Adv Funct Materials, 2022, 32
DOI: 10.1002/adfm.202107574

Light‐Activated Nanocatalyst for Precise In‐Situ Antimicrobial Synthesis via Photoredox‐Catalytic Click Reaction

Minyang Zhao, Lei Cao, Qingqing Bai, Yaru Lu, Bowen Li, Wenbo Wu, Jinzhou Ye, Xinhan Chen, Zhihong Wang, Bin Liu and Duo Mao

Angewandte Chemie, 2024, 136
DOI: 10.1002/ange.202408918

Biology-Oriented Design Strategies of AIE Theranostic Probes

Duo Mao and Bin Liu

Matter, 2021, 4, 350
DOI: 10.1016/j.matt.2020.12.006

Dipole‐Dipole and Anion‐π+ Interaction Manipulation Synergistically Enhance Intrinsic Antibacterial Activities of AIEgens

Guoyu Jiang, Rong Hu, Chunbin Li, Jianye Gong, Jianguo Wang, Jacky W. Y. Lam, Anjun Qin and Ben Zhong Tang

Chemistry A European J, 2022, 28
DOI: 10.1002/chem.202202388

Metabolically Labeling Near-Infrared-II Excited Fluorophores on Bacterial Outer Membrane Vesicles for Targeted Imaging and Photoimmunotherapy of Gram-Negative Bacterial Peritonitis

Na Li, Zelong Li, Jian Zou, Fan Wu, Minghui Wang, Jian Xiong, Guilong Wu, Guodong Chen, Xiaofeng Tan and Qinglai Yang

Anal. Chem., 2026, 98, 3202
DOI: 10.1021/acs.analchem.5c06887

A cytoderm metabolic labeling AIEgen for rapid detection and intracellular ablation of Mycobacterium tuberculosis

Guiqin Dai, Yuan Luo, Mingfeng Liao, Pengfei Zhang, Hong Pan, Ting Yin, Qianting Yang, Sirui Zheng, Jianhong Liao, Deliang Liu, Zhuojun He, Wenchang Zhao, Lijun Song, Pengfei Zhao, Lintao Cai, Zheng Zhang and Mingbin Zheng

Cell Reports Physical Science, 2023, 4, 101238
DOI: 10.1016/j.xcrp.2022.101238

An AIE‐active probe for efficient detection and high‐throughput identification of outer membrane vesicles

Fei Wang, Po‐Yu Ho, Chuen Kam, Quanzhi Yang, Jinzhao Liu, Weiping Wang, Engui Zhao and Sijie Chen

Aggregate, 2023, 4
DOI: 10.1002/agt2.312

Micrococcal Nuclease-Activated Theranostic Probe for Specific Imaging and Targeting Photothermal Eradication of Intracellular Staphylococcus aureus in Joints in vivo

Mingrong Wu, Fengqiong Gao, Yaqing Zhang, Zhenping Gao, Danna Cao, Hong Xiao and Erqun Song

Biosensors and Bioelectronics, 2026, 305, 118661
DOI: 10.1016/j.bios.2026.118661

Bioorthogonal reactions and AIEgen-based metabolically engineered theranostic systems

Kenry and Bin Liu

Chem, 2023, 9, 2078
DOI: 10.1016/j.chempr.2023.04.004

Expanding Our Horizons: AIE Materials in Bacterial Research

Michelle M. S. Lee, Eric Y. Yu, Joe H. C. Chau, Jacky W. Y. Lam, Ryan T. K. Kwok and Ben Zhong Tang

Advanced Materials, 2025, 37
DOI: 10.1002/adma.202407707

AIEgens for Bacterial Imaging and Ablation

Qinggele Borjihan, Haixia Wu, Alideertu Dong, Hui Gao and Ying‐Wei Yang

Adv Healthcare Materials, 2021, 10
DOI: 10.1002/adhm.202100877

Targeted antibacterial photodynamic therapy with aggregation‐induced emission photosensitizers

Biru Wu, Kenry and Fang Hu

Interdisciplinary Medicine, 2024, 2
DOI: 10.1002/INMD.20230038

Development and Applications of D‐Amino Acid Derivatives‐based Metabolic Labeling of Bacterial Peptidoglycan

Yongfang Zheng, Xinyu Zhu, Mingyi Jiang, Fangfang Cao, Qing You and Xiaoyuan Chen

Angewandte Chemie, 2024, 136
DOI: 10.1002/ange.202319400

Photosensitizers with Aggregation-induced Emission and Their Biomedical Applications

Luojia Chen, Xingran Wang, Yuncong Yuan, Rui Hu, Qingrong Chen, Lijun Zhu, Meijia Gu and Chao Shen

Engineered Regeneration, 2022, 3, 59
DOI: 10.1016/j.engreg.2022.01.005

Aggregation-induced emission luminogens for intracellular bacteria imaging and elimination

Mingji Jiang, Jing Kang and Alideertu Dong

Biosensors and Bioelectronics, 2025, 267, 116873
DOI: 10.1016/j.bios.2024.116873

Progress and trends of photodynamic therapy: From traditional photosensitizers to AIE-based photosensitizers

Shuai Wang, Xiao Wang, Liangmin Yu and Mingliang Sun

Photodiagnosis and Photodynamic Therapy, 2021, 34, 102254
DOI: 10.1016/j.pdpdt.2021.102254

The Rise of AIE‐Peptide Systems: Design Principles, Multifunctional Applications, and Future Perspectives

Yang Qian Hou, Ben Zhong Tang and Dong Wang

Advanced Materials, 2026, 38
DOI: 10.1002/adma.202514134

Research progress of contrast agents for bacterial infection imaging in vivo

Yaqing Zhang, Mengqi Hao, Linyao Li, Qin Luo, Siyu Deng, Yun Yang, Yan Liu, Weiwei Fang and Erqun Song

TrAC Trends in Analytical Chemistry, 2023, 159, 116916
DOI: 10.1016/j.trac.2023.116916

Nanotechnology Approaches for Rapid Detection and Theranostics of Antimicrobial Resistant Bacterial Infections

Survanshu Saxena, Kapil Punjabi, Nadim Ahamad, Subhasini Singh, Prachi Bendale and Rinti Banerjee

ACS Biomater. Sci. Eng., 2022, 8, 2232
DOI: 10.1021/acsbiomaterials.1c01516

AIE Bioconjugates for Accurate Identification and In Vivo Targeted Treatment of Bacterial Infection Based on Bioorthogonal Reaction

Yuan Fang, Xin Liu, Hanqiong Guo, Yujie Zhang, Haotian Wu, Xiao Zhou, Xiying Chen, Haijuan Qin, Heqi Gao and Yaqing Liu

Adv Healthcare Materials, 2023, 12
DOI: 10.1002/adhm.202300044

Lysosome-Targeting Aggregation-Induced Emission Nanoparticle Enables Adoptive Macrophage Transfer-Based Precise Therapy of Bacterial Infections

Peng Wang, Biru Wu, Min Li, Yuchen Song, Chengjian Chen, Guangxue Feng, Duo Mao, Fang Hu and Bin Liu

ACS Nano, 2023, 17, 10365
DOI: 10.1021/acsnano.3c00796

Metabolic Labeling Strategy Boosted Antibacterial Efficiency for Photothermal and Photodynamic Synergistic Bacteria-Infected Wound Therapy

Na Li, Guilong Wu, Li Tang, Wei Zhou, Sha Yang, Qi Pan, Minghui Wang, Peixian Wu, Hao Xiao, Yuxuan He, Xiaofeng Tan and Qinglai Yang

ACS Appl. Mater. Interfaces, 2022, 14, 46362
DOI: 10.1021/acsami.2c15759

Strategies of Detecting Bacteria Using Fluorescence-Based Dyes

Shin A Yoon, Sun Young Park, Yujin Cha, Lavanya Gopala and Min Hee Lee

Front. Chem., 2021, 9
DOI: 10.3389/fchem.2021.743923

Mussel-like polydopamine-assisted aggregation-induced emission nanodot for enhanced broad-spectrum antimicrobial activity: In vitro and in vivo validation

Leina Dou, Xiaonan Wang, Yuchen Bai, Qing Li, Liang Luo, Wenbo Yu, Zhanhui Wang, Kai Wen and Jianzhong Shen

International Journal of Biological Macromolecules, 2024, 282, 136762
DOI: 10.1016/j.ijbiomac.2024.136762

Crystal structure of 1,4-dibromo-2,5-bis(prop-2-yn-1-yloxy)benzene, C12H8Br2O2

Zhi-Yong Wang, Qi-Long Zhang, Xiu-Ming Zhang, Xu Zhou, Xian-Jiong Yang and Hong Xu

Zeitschrift für Kristallographie - New Crystal Structures, 2023, 238, 1199
DOI: 10.1515/ncrs-2023-0401