Fluorescent small molecule donors

Guang Chen, Jing Yu, Luling Wu, Xinrui Ji, Jie Xu, Chao Wang, Siyue Ma, Qing Miao, Linlin Wang, Chen Wang, Simon E. Lewis, Yanfeng Yue, Zhe Sun, Yuxia Liu, Bo Tang and Tony D. James

Chem. Soc. Rev., 2024, 53, 6345
DOI: 10.1039/D3CS00124E

A two-photon responsive hydroxyphenylquinazolinone (HPQ)-based fluorescent organic nanoprodrug for H2S release against oxidative stress

Amrita Chaudhuri, Tara Singha, Bikash Chandra Jena, Maniklal Shee, Prasanta Kumar Datta, Mahitosh Mandal and N. D. Pradeep Singh

Chem. Commun., 2023, 59, 1177
DOI: 10.1039/D2CC05768A

A dual-response NIR fluorescent probe for separately and continuously recognizing H2S and Cys with different fluorescence signals and its applications

Lisha Yue, Yin Ai, Gang Liu, Haichang Ding and Shouzhi Pu

Analyst, 2023, 148, 4829
DOI: 10.1039/D3AN00871A

Single component photoresponsive fluorescent organic nanoparticles: a smart platform for improved biomedical and agrochemical applications

Amrita Chaudhuri, Amrita Paul, Antara Sikder and N. D. Pradeep Singh

Chem. Commun., 2021, 57, 1715
DOI: 10.1039/D0CC07183H

Construction of a Z-scheme g-C3N4/Ag/AgI heterojunction for highly selective photoelectrochemical detection of hydrogen sulfide

Hongmei Zeng, Yaling Liu, Zhigang Xu, Yajun Wang, Yaqin Chai, Ruo Yuan and Hongyan Liu

Chem. Commun., 2019, 55, 11940
DOI: 10.1039/C9CC05356E

Spatiotemporal photo-release of hydrogen sulphide from β-carboline-derived nanoparticles for therapeutic applications

Antara Sikder, Rakesh Mengji, Saugat Mondal, Avijit Jana and N. D. Pradeep Singh

J. Mater. Chem. B, 2023, 11, 5131
DOI: 10.1039/D3TB00588G

Small molecule generators of biologically reactive sulfur species

Prerona Bora, Preeti Chauhan, Kundansingh A. Pardeshi and Harinath Chakrapani

RSC Adv., 2018, 8, 27359
DOI: 10.1039/C8RA03658F

Tetraphenylethylene conjugated p-hydroxyphenacyl: fluorescent organic nanoparticles for the release of hydrogen sulfide under visible light with real-time cellular imaging

C. Parthiban, Pavithra M., L. Vinod Kumar Reddy, Dwaipayan Sen, Melvin Samuel S. and N. D. Pradeep Singh

Org. Biomol. Chem., 2018, 16, 7903
DOI: 10.1039/C8OB01629A

A water soluble light activated hydrogen sulfide donor induced by an excited state meta effect

Manoranjan Bera, Somnath Maji, Amrita Paul, Souvik Ray, Tapas Kumar Maiti and N. D. Pradeep Singh

Org. Biomol. Chem., 2019, 17, 9059
DOI: 10.1039/C9OB01502G

Fluorogenic hydrogen sulfide (H2S) donors based on sulfenyl thiocarbonates enable H2S tracking and quantification

Yu Zhao, Matthew M. Cerda and Michael D. Pluth

Chem. Sci., 2019, 10, 1873
DOI: 10.1039/C8SC05200J

Thioredoxin reductase-triggered fluorogenic donor of hydrogen sulfide: a model study with a symmetrical organopolysulfide probe with turn-on near-infrared fluorescent emission

Sulendar K. Mahato, Debojit Bhattacherjee, Pallavi Barman and Krishna P. Bhabak

J. Mater. Chem. B, 2022, 10, 2183
DOI: 10.1039/D1TB02425F

Real-time monitoring of a photoactivated hydrogen persulfide donor for biological entities

Amrita Chaudhuri, Yarra Venkatesh, Bikash Chandra Jena, Krishna Kalyani Behara, Mahitosh Mandal and N. D. Pradeep Singh

Org. Biomol. Chem., 2019, 17, 8800
DOI: 10.1039/C9OB01982K

Tweaking the proton transfer triggered proton transfer of 3,5-bis(2-hydroxyphenyl)-1H-1,2,4-triazole

Minati Das, Saugata Sahu and G. Krishnamoorthy

Phys. Chem. Chem. Phys., 2019, 21, 15669
DOI: 10.1039/C9CP02281C

Proton transfer triggered proton transfer: a self-assisted twin excited state intramolecular proton transfer

Saugata Sahu, Minati Das, Aditya Kumar Bharti and G. Krishnamoorthy

Phys. Chem. Chem. Phys., 2018, 20, 27131
DOI: 10.1039/C8CP03835J

One- and two-photon responsive sulfur dioxide (SO2) donors: a combinatorial drug delivery for improved antibiotic therapy

Yarra Venkatesh, Kumari Shanti Kiran, Sk. Sheriff Shah, Amrita Chaudhuri, Satyahari Dey and N. D. Pradeep Singh

Org. Biomol. Chem., 2019, 17, 2640
DOI: 10.1039/C9OB00090A

Modulation of excited-state photodynamics of ESIPT probe 1′-hydroxy-2′-acetonaphthone (HAN) on interaction with bovine serum albumin

Mhejabeen Sayed, Jyoti Balayan, Prabhat K. Singh and Haridas Pal

Journal of Photochemistry and Photobiology A: Chemistry, 2020, 400, 112651
DOI: 10.1016/j.jphotochem.2020.112651

Gasotransmitter delivery for bone diseases and regeneration

Yaoyao Xu, Yanyue Li, Ang Gao, Paul K. Chu and Huaiyu Wang

TIL, 2023, 1, 100015
DOI: 10.59717/j.xinn-life.2023.100015

Self-Reporting H2S Donors: Integrating H2S Release with Real-Time Fluorescence Detection

Changlei Zhu and John C. Lukesh

Chemistry, 2025, 7, 116
DOI: 10.3390/chemistry7040116

Insights into the Mechanism of Thiol-Triggered COS/H2S Release from N-Dithiasuccinoyl Amines

Shengchao Zhou, Yujie Mou, Miao Liu, Qian Du, Basharat Ali, Jurupula Ramprasad, Chunhua Qiao, Li-Fang Hu and Xingyue Ji

J. Org. Chem., 2020, 85, 8352
DOI: 10.1021/acs.joc.0c00559

Rational Construction of a Mitochondria-Targeted Reversible Fluorescent Probe with Intramolecular FRET for Ratiometric Monitoring Sulfur Dioxide and Formaldehyde

Jinxiao Lyu, Chunfei Wang and Xuanjun Zhang

Biosensors, 2022, 12, 715
DOI: 10.3390/bios12090715

Curcumin–Cu(II) Ensemble-Based Fluorescence “Turn-On” Mode Sensing the Plant Defensive Hormone Salicylic Acid In Situ and In Vivo

Chong Chen, Lin-Lin Yang, A-Ling Tang, Pei-Yi Wang, Rong Dong, Zhi-Bing Wu, Zhong Li and Song Yang

J. Agric. Food Chem., 2020, 68, 4844
DOI: 10.1021/acs.jafc.0c01283

A Photoactivatable Formaldehyde Donor with Fluorescence Monitoring Reveals Threshold To Arrest Cell Migration

Lukas P. Smaga, Nicholas W. Pino, Gabriela E. Ibarra, Vishnu Krishnamurthy and Jefferson Chan

J. Am. Chem. Soc., 2020, 142, 680
DOI: 10.1021/jacs.9b11899

An Expanded Palette of Fluorescent COS/H2S‐Releasing Donors for H2S Delivery, Detection, and In Vivo Application

Kaylin G. Fosnacht, Jonathan Dorogin, Payton M. Jefferis, Marian H. Hettiaratchi and Michael D. Pluth

Angew Chem Int Ed, 2024, 63
DOI: 10.1002/anie.202402353

Activatable Small-Molecule Hydrogen Sulfide Donors

Carolyn M. Levinn, Matthew M. Cerda and Michael D. Pluth

Antioxidants & Redox Signaling, 2020, 32, 96
DOI: 10.1089/ars.2019.7841

Prodrugs of hydrogen sulfide and related sulfur species: recent development

Zheng-Nan YUAN, Yue-Qin ZHENG and Bing-He WANG

Chinese Journal of Natural Medicines, 2020, 18, 296
DOI: 10.1016/S1875-5364(20)30037-6

Dual‐Stimuli‐Activatable Hybrid Prodrug for the Self‐Immolative Delivery of an Anticancer Agent and Hydrogen Sulfide with Turn‐On Fluorescence

Abu Sufian, Md. Badirujjaman, Pallavi Barman and Krishna P. Bhabak

Chemistry A European J, 2023, 29
DOI: 10.1002/chem.202302197

ESIPT-, AIE-, and AIE + ESIPT-Based Light-Activated Drug Delivery Systems and Bioactive Donors for Targeted Disease Treatment

Amit Kumar Singh, Asha V Nair, Sk. Sheriff Shah, Souvik Ray and N. D. Pradeep Singh

J. Med. Chem., 2023, 66, 3732
DOI: 10.1021/acs.jmedchem.2c01466

An ICT lighten ratiometric and NIR fluorogenic probe to visualize endogenous/exogenous hydrogen sulphide and imaging in mice

Qing Wu, Caixia Yin, Ying Wen, Yongbin Zhang and Fangjun Huo

Sensors and Actuators B: Chemical, 2019, 288, 507
DOI: 10.1016/j.snb.2019.03.053

A thiol-activated near-infrared fluorescent H2S donor for visualizing H2S release and its applications

Jicheng Wang, Xuan Wang, Nianwei Wang, Yikun Ren, Lin Dong, Huarong Xu, Huiming Hua and Dahong Li

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2026, 347, 126976
DOI: 10.1016/j.saa.2025.126976

A photoactivatable H2S-releasing photosensitizer: Alleviating hypoxia and evoking pyroptosis for gas-augmented photodynamic and immune therapy

Meihui Su, Dongjie Li, Debin Kong, Luyi Zhang, Yunfeng Zhou, Hongyu Liu, Yunjian Yu and Hui Gao

Chemical Engineering Journal, 2025, 524, 169638
DOI: 10.1016/j.cej.2025.169638

Toxicity, bioactivity, release of H2S in vivo and pharmaco-kinetics of H2S-donors with thiophosphamide structure

Jinlong Zhang, Qiuping Zhang, Yanni Wang, Jili Li, Zhongjie Bai, Quanyi Zhao, Dian He, Zhen Wang, Jingke Zhang and Yonglin Chen

European Journal of Medicinal Chemistry, 2019, 176, 456
DOI: 10.1016/j.ejmech.2019.05.017

A UV-triggered water-soluble H2S donor for visual delivery of H2S in organisms and its application in plant protection

Yukun Zhang, Chen Xu, Hui Sun, Jindong Ai and Mingguang Ren

Dyes and Pigments, 2023, 219, 111653
DOI: 10.1016/j.dyepig.2023.111653

One- and Two-Photon-Activated Cysteine Persulfide Donors for Biological Targeting

Amrita Chaudhuri, Yarra Venkatesh, Joyjyoti Das, Moumita Gangopadhyay, Tapas K. Maiti and N. D. Pradeep Singh

J. Org. Chem., 2019, 84, 11441
DOI: 10.1021/acs.joc.9b01224

The evolving landscape for cellular nitric oxide and hydrogen sulfide delivery systems: A new era of customized medications

Kearsley M. Dillon, Ryan J. Carrazzone, John B. Matson and Khosrow Kashfi

Biochemical Pharmacology, 2020, 176, 113931
DOI: 10.1016/j.bcp.2020.113931

Review of Hydrogen Sulfide Based on Its Activity Mechanism and Fluorescence Sensing

Jinlong Zhang, Quan Jing, Fei Gao, Fuxin Zhang, Dong Pei, Duolong Di and Jun Hai

Targets, 2024, 2, 202
DOI: 10.3390/targets2030012

Recent advances in the ESIPT-based drug delivery systems for targeted diseases treatment

Hossein Roohi and Mina Rouhi

Dyes and Pigments, 2025, 240, 112863
DOI: 10.1016/j.dyepig.2025.112863

Intelligent polymeric hydrogen sulfide delivery systems for therapeutic applications

Fan Rong, Tengjiao Wang, Qian Zhou, Haowei Peng, Jingtian Yang, Quli Fan and Peng Li

Bioactive Materials, 2023, 19, 198
DOI: 10.1016/j.bioactmat.2022.03.043

A Reactive Oxygen Species (ROS) Activated Hydrogen Sulfide (H2S) Donor with Self-Reporting Fluorescence

Ning Zhang, Ping Hu, Yanfang Wang, Qing Tang, Qiang Zheng, Zhanlong Wang and Yun He

ACS Sens., 2020, 5, 319
DOI: 10.1021/acssensors.9b01093

Phototriggered Hydrogen Persulfide Donors via Hydrosulfide Radical Formation Enhancing the Reactive Sulfur Metabolome in Cells

Biswajit Roy, Meg Shieh, Tsuyoshi Takata, Minkyung Jung, Eshani Das, Shi Xu, Takaaki Akaike and Ming Xian

J. Am. Chem. Soc., 2024, 146, 30502
DOI: 10.1021/jacs.4c11540

Photorelease of Hydrogen Sulfide (H2S) from Stable Water-Soluble Precursors

Kun Wang and Vladimir Popik

J. Org. Chem., 2025, 90, 13938
DOI: 10.1021/acs.joc.5c01997

Cyclic Sulfenyl Thiocarbamates Release Carbonyl Sulfide and Hydrogen Sulfide Independently in Thiol-Promoted Pathways

Yu Zhao, Andrea K. Steiger and Michael D. Pluth

J. Am. Chem. Soc., 2019, 141, 13610
DOI: 10.1021/jacs.9b06319

Tailoring the AIE Chromogen 2-(2-Hydroxyphenyl)benzothiazole for Use in Enzyme-Triggered Molecular Brachytherapy

Zhiyuan Wu, Jinghuai Dou, Kathy-Uyen Nguyen, Jayden C. Eppley, Kittipan Siwawannapong, Yunlong Zhang and Jonathan S. Lindsey

Molecules, 2022, 27, 8682
DOI: 10.3390/molecules27248682

A new coumarin-based fluorescent probe for selective recognition of Cu2+ and S2− in aqueous solution and living cells

Zhen Liu, Linjing Liu, Jiulong Li, Yuanyuan Qin, Chenyang Zhao, Yang Mi, Guoping Li, Tiesheng Li and Yangjie Wu

Tetrahedron, 2019, 75, 3951
DOI: 10.1016/j.tet.2019.05.057

An Activatable Near-Infrared Fluorescence Hydrogen Sulfide (H2S) Donor for Imaging H2S Release and Inhibiting Inflammation in Cells

Xinyue Zhao, Lulu Ning, Xiaoman Zhou, Zhihui Song, Jianjian Zhang, Feng Guan and Xiao-Feng Yang

Anal. Chem., 2021, 93, 4894
DOI: 10.1021/acs.analchem.0c05081

External stimuli-responsive gasotransmitter prodrugs: Chemistry and spatiotemporal release

Xingyue Ji and Zhiyuan Zhong

Journal of Controlled Release, 2022, 351, 81
DOI: 10.1016/j.jconrel.2022.09.026

Strategies for the Design of Donors and Precursors of Reactive Sulfur Species

Shi Xu, Akil Hamsath, Deshka L. Neill, Yingying Wang, Chun‐tao Yang and Ming Xian

Chemistry A European J, 2019, 25, 4005
DOI: 10.1002/chem.201804895

Esterase-Activated Hydrogen Sulfide Donors with Self-Reporting Fluorescence Properties and Highly Tunable Rates of Delivery

Changlei Zhu, Chen Chen, Devin E. Weaver and John C. Lukesh

ACS Chem. Biol., 2024, 19, 1910
DOI: 10.1021/acschembio.4c00396

Reversible and reusable selective detection of cyanide in aqueous solution using BODIPY with activated C–H groups

Chao Fu, Zhichao Wang, Caihui Rao, Zheyao Li, Lu Chen, Tingting Zhu, Fengping Yi, Zi-Jian Yao and Chuanxiang Liu

Dyes and Pigments, 2019, 170, 107598
DOI: 10.1016/j.dyepig.2019.107598

Progress and perspective on hydrogen sulfide donors and their biomedical applications

Zi‐Long Song, Lanning Zhao, Tao Ma, Alsiddig Osama, Tong Shen, Yilin He and Jianguo Fang

Medicinal Research Reviews, 2022, 42, 1930
DOI: 10.1002/med.21913

Photolabile Protecting Groups Based on the Excited State Meta Effect: Development and Application†

Pengfei Wang and Chaeeun Lim

Photochem & Photobiology, 2023, 99, 221
DOI: 10.1111/php.13690

New possible silver lining for pancreatic cancer therapy: Hydrogen sulfide and its donors

Xu Hu, Yan Xiao, Jianan Sun, Bao Ji, Shanshan Luo, Bo Wu, Chao Zheng, Peng Wang, Fanxing Xu, Keguang Cheng, Huiming Hua and Dahong Li

Acta Pharmaceutica Sinica B, 2021, 11, 1148
DOI: 10.1016/j.apsb.2020.10.019

Recent Developments On Activatable Turn‐On Fluorogenic Donors of Hydrogen Sulfide (H2S)

Roopjyoti Misra, Hirak Jyoti Bhuyan, Amlan Dutta and Krishna P. Bhabak

ChemMedChem, 2024, 19
DOI: 10.1002/cmdc.202400251

Near-infrared photothermal release of hydrogen sulfide from nanocomposite hydrogels for anti-inflammation applications

Yan Huang, Haifeng Li, Xiaoxiao He, Xiaohai Yang, Li Li, Songyang Liu, Zhen Zou, Kemin Wang and Jianbo Liu

Chinese Chemical Letters, 2020, 31, 787
DOI: 10.1016/j.cclet.2019.05.025

Visible-Light -Triggered Fluorescent Organic Nanoparticles for Chemo-Photodynamic Therapy with Real-Time Cellular Imaging

C. Parthiban, Pavithra M., Vinod Kumar Reddy L., Dwaipayan Sen, Melvin Samuel S. and N. D. Pradeep Singh

ACS Appl. Nano Mater., 2018, 1, 6281
DOI: 10.1021/acsanm.8b01495

Metal Coordination Complexes as Therapeutic Agents for Ischemia-Reperfusion Injury

Nicholas P. Bigham and Justin J. Wilson

J. Am. Chem. Soc., 2023, 145, 9389
DOI: 10.1021/jacs.3c01984

An Expanded Palette of Fluorescent COS/H2S‐Releasing Donors for H2S Delivery, Detection, and In Vivo Application

Kaylin G. Fosnacht, Jonathan Dorogin, Payton M. Jefferis, Marian H. Hettiaratchi and Michael D. Pluth

Angewandte Chemie, 2024, 136
DOI: 10.1002/ange.202402353

Hydrogen sulfide in cancer therapy: Intelligent delivery platforms and synergistic therapeutic paradigms

Nailin Yang, Yichi Cai, Shumin Sun, Jihu Nie, Fei Gong, Zifan Pei and Liang Cheng

Advanced Drug Delivery Reviews, 2025, 227, 115717
DOI: 10.1016/j.addr.2025.115717

Visible-to-NIR-Light Activated Release: From Small Molecules to Nanomaterials

Roy Weinstain, Tomáš Slanina, Dnyaneshwar Kand and Petr Klán

Chem. Rev., 2020, 120, 13135
DOI: 10.1021/acs.chemrev.0c00663

Synthesis of Sulfur-35-Labeled Trisulfides and GYY-4137 as Donors of Radioactive Hydrogen Sulfide

Eric M. Brown, James P. Grace, Nimesh P. R. Ranasinghe Arachchige and Ned B. Bowden

ACS Omega, 2023, 8, 27576
DOI: 10.1021/acsomega.3c03258

Antibacterial gas therapy: Strategies, advances, and prospects

Tian-Yu Wang, Xiao-Yu Zhu and Fu-Gen Wu

Bioactive Materials, 2023, 23, 129
DOI: 10.1016/j.bioactmat.2022.10.008

Design and Synthesis of a NTR-Sensitive Fluorescent H2S Donor as a Potential Therapeutic Agent for Myocardial Ischemia–Reperfusion Injury

Ning Zhang, Tao Li, Pengjie Zhong, Tengchuan Fu, Luoyi Li, Mingtao Peng, Yuanqiang Wang, Yifei Lu and Mengyun Yao

J. Med. Chem., 2025, 68, 14981
DOI: 10.1021/acs.jmedchem.5c01169