Triplet nitrene-mediated photocatalytic azidation of tertiary C(sp3)–H bonds

Abstract

A photocatalytic C(sp³)–H azidation involving a triplet nitrene as a hydrogen atom abstractor is described. The key nitrene intermediate is generated through energy transfer to a sulfonyl azide, which also functions as an azide source. This method exhibits excellent selectivity for tertiary C-H bonds and is applicable to leucine-containing dipeptides.