A Pd-catalyzed, regio- and diastereoselective cascade reaction of biphenyl amines with 1,6-enynes via non-rollover cyclometallation has been described for the synthesis of benzoisoindolinone derivatives.
Crosstalk phenomenon between the cathode and anode, that is, the diffusion of parasitic products across separator to counter electrode, is receiving intensive attention because of its significant effect on high-energy battery life and safety.
A Pd-catalyzed rollover cascade dual C–H annulation of aryl phenols with alkynols for producing phenanthrene scaffolds in a regioselective manner was developed. Necessary control, KIE and deuterium experiments were conducted to determine the reaction mechanism.
Directing group-assisted selective C–H bond activation of six-membered N-heterocycles and benzo-fused N-heterocycles has been reported.
This review highlights emerging catalyst systems and provides mechanistic insights into transition metal-catalyzed alkyne annulations, emphasizing their significance in complex molecule synthesis and progress towards sustainable chemistry.