A nitroreductase (NTR) responsive fluorescent probe with long wavelength fluorescence emission was used to determine the NTR activity of a selection of bacterial species under a range of different bacterial growth conditions.
We developed Cy5-NO2, a nitro fluorescent probe enabling real-time NTR monitoring with 30-fold enhancement upon reduction, detecting and imaging live E. coli and S. aureus via CLSM for sensitive bacterial detection.
A ratiometric, near-infrared fluorescent molecular probe reports nitroreductase activity and enables three-dimensional optical sectioning of intact tumor spheroids with visualization of individual hypoxic cells.
An accurate and selective ratio-metric fluorescent sensor for visualizing nitroreductase in hypoxic cells.
A novel low dimensional (LD) Ln-MOF crystal is synthesized through the dimensional regulation effect of dipicolinic acid (DPA) and used to monitor nitroreductase (NTR) activity in living bacteria.