Zahrasadat Momenzadeh Abardeh, Alireza Salimi and Artem R. Oganov
CrystEngComm, 2025,27, 5514-5526
Abstract
Synthon modularity is valuable for crystal structure prediction (CSP), allowing for the rationalization of polymorphs and co-crystals.
Yingying Jiang, Hang Zhao, Lunjie Chen, Siping Wei, Jun Wang, Lin Wang and Qiang Fu
Chem. Commun., 2025,61, 5814-5817
Abstract
This study enables rapid synthesis of pomalidomide-conjugates for PROTACs by optimizing temperature and reagent addition, reducing reaction time to minutes with fewer byproducts, and improving efficiency and sustainability in drug development.
Duncan K. Brownsey, Christopher J. Gafuik, Dae-Sun Kim, Leonie O’Sullivan, Evgueni Gorobets, Samuel Krukowski, Madison Turk, Craig N. Jenne, Douglas J. Mahoney and Darren J. Derksen
Chem. Commun., 2023,59, 14532-14535
From themed collection:
2023 Pioneering Investigators
Abstract
The fluorescent properties of pomalidomide derivatives have been utilised to develop a high-throughput imaging method suitable for rapid screening of protein degrader candidates.
Diaaeldin I. Abdallah, Johan Israelian, Lina S. Hasan, Naman H. Patel, Jeffrey W. Keillor, Timothy B. Wright, Bilal Saqib, Elvin D. de Araujo and Patrick T. Gunning
Chem. Commun., 2025,61, 4670-4673
Abstract
A rapid and efficient microwave-assisted synthesis of pomalidomide analogs, improving upon prior methods to accelerate the discovery and optimization of degraders like clinical candidate ARV-110.
Suvankar Banerjee, Nilanjan Adhikari and Balaram Ghosh
RSC Med. Chem., 2026,17, 208-224
Abstract
Discovery timeline of HDAC8-degrading PROTACs.