We synthesized and screened 28 new fluorine-containing S1PR1 compounds; 9 potent and selective compounds were F-18 radiolabeled with good radiochemical yields. In vivo PET imaging evaluation was performed for these radiotracers as CNS imaging agents.
A one-pot approach is presented to upgrade PCL into nylon-6 monomers (EACA and CPL) over Ru catalysts, affording products in a total yield of EACA and CPL up to 90.2%.
Green amine synthesis is assessed using the CHEM21 green metrics toolkit, offering a step-by-step guide for sustainability evaluation and promoting environmentally conscious transformations.
The first catalytic dehydrative amidations using aqueous solutions of methylamine, ethylamine, and dimethylamine as amine sources have been successfully achieved.
A palladium catalyzed intramolecular C(sp2)–H amination promoted by in situ nitration of the directing group using a readily available aluminum nitrate as the oxidant is reported.