An expedient ruthenium(ii) catalyzed multicomponent access to phthalazinones bearing trisubstituted alkenes

Manikandan Sekar, Ramdas Sreedharan, Egambaram Premkumar, Rajeshwaran Purushothaman and Thirumanavelan Gandhi

Org. Biomol. Chem., 2025, 23, 2411
DOI: 10.1039/D4OB01890G

Photocatalytic multicomponent alkene dicarbofunctionalization via PCET/nickel dual catalysis

Yeersen Patehebieke, Victoria Jansson, Jakob Öberg and Carl-Johan Wallentin

Chem. Sci., 2026, 17, 7690
DOI: 10.1039/D6SC00382F

Room temperature C–O bond cleavage of vinyl cyclic synthons via a metallaphotoredox approach

Santosh Kumar Keshri and Manmohan Kapur

Chem. Commun., 2024, 60, 11164
DOI: 10.1039/D4CC02815E

Nickel/photoredox-catalyzed three-component silylacylation of acrylates via chlorine photoelimination

Yejin Koo and Sungwoo Hong

Chem. Sci., 2024, 15, 7707
DOI: 10.1039/D4SC02164A

Direct alkene functionalization via photocatalytic hydrogen atom transfer from C(sp3)–H compounds: a route to pharmaceutically important molecules

Hangqian Fan, Yuxin Fang and Jingbo Yu

Chem. Commun., 2024, 60, 13796
DOI: 10.1039/D4CC05026F

Cobalt-catalyzed conformationally restricted alkylarylation enables divergent access to Csp3-rich N-heterocycles

Kaixin Chen, Jie Lin, Jing Jing, Junda Wang, Jiayu Hu, Hong Yi, Aiwen Lei and Jie Li

Chem. Sci., 2024, 15, 16250
DOI: 10.1039/D4SC04056B

A TBADT photocatalyst-enabled radical-induced cyclization pathway to access functionalized dihydrobenzofurans

Punith S Gowda, Duddu S. Sharada and Gedu Satyanarayana

Chem. Commun., 2023, 59, 9094
DOI: 10.1039/D3CC02340K

Electrochemical iron-catalyzed difunctionalization of olefins: efficient and sustainable access to β-heteroarylated esters

Binbin Chen, Jun Xu, Zeyi Wang, Ling Yang, Qianyuan Liu and Pengfei Zhang

Green Chem., 2025, 27, 10656
DOI: 10.1039/D5GC02319J

Intermolecular 1,2-difunctionalization of alkenes

Yuanrui Wang, Zhi-Peng Bao, Xu-Dong Mao, Ming Hou and Xiao-Feng Wu

Chem. Soc. Rev., 2025, 54, 9530
DOI: 10.1039/D5CS00670H

The road to green efficiency: exploration of multicomponent reactions from transition metal catalysis to no catalyst conditions

Jie Li, Jiajun Cui, Hongying Guo, Jiyou Yang and Weiwei Huan

React. Chem. Eng., 2025, 10, 500
DOI: 10.1039/D4RE00522H

Dual photoredox/nickel-catalyzed Mizoroki–Heck cross-coupling reactions

Jun Dong, Yanfei Hu, Yan Tang, Fen Zhao, Yongyun Zhou and Baomin Fan

Org. Chem. Front., 2024, 11, 3562
DOI: 10.1039/D4QO00572D

Novel indolespiro bicoumarins: synthesis and their antifungal activity

Zhengyu Liu, Qihe Liu, Li Chen, Yukang Liu, Ting Zhao, Liuqing Yang, Min Zhang and Changsheng Yao

Org. Biomol. Chem., 2025, 23, 4960
DOI: 10.1039/D5OB00448A

Radical acylation: concepts, synthetic applications and directions

Yue Zhang, Yili Zhang, Jian Lin, Zhaodong Li and Huicai Huang

Org. Chem. Front., 2023, 10, 1056
DOI: 10.1039/D2QO01846B

The mechanism of visible light-induced C–C cross-coupling by Csp3–H bond activation

Bholanath Maity, Sayan Dutta and Luigi Cavallo

Chem. Soc. Rev., 2023, 52, 5373
DOI: 10.1039/D2CS00960A

TBADT/nickel co-catalyzed arylation of hydrosilanes with aryl halides

Kaixin Fu, Zilong Yan, Yong Lu, Zhaolin Fu, Weiping Zheng, Shuanhu Gao, Shengchao Yang and Dong Xing

Org. Chem. Front., 2026, 13, 1125
DOI: 10.1039/D5QO01479D

Direct acylation and alkynylation of hydrocarbons via synergistic decatungstate photo-HAT/nickel catalysis

Wenfeng Liu, Yang Ke, Chuhan Liu and Wangqing Kong

Chem. Commun., 2022, 58, 11937
DOI: 10.1039/D2CC04408K

Visible-light-mediated β-acylative divergent alkene difunctionalization with Katritzky salt/CO2

Shantanu Nandi, Pritha Das, Subhodeep Das, Shuvam Mondal and Ranjan Jana

Green Chem., 2023, 25, 3633
DOI: 10.1039/D3GC00143A

Modifications of terpenoids via inert aliphatic C–H bond heteroarylation with heteroarenes

Shuxin Yang, Huirong Li, Jiaxing Lv, Lu Wang, Yongye Lu, Guangshun Sun, Xiangyin Wang, Qikun Yin, Yi Bi and Xianhe Fang

Chem. Commun., 2025, 61, 8564
DOI: 10.1039/D5CC01708D

Recent advances in dual photoredox/nickel catalyzed alkene carbofunctionalised reactions

Anilkumar Kommoju, Kattamuri Snehita, Kandi Sowjanya, Saratchandra Babu Mukkamala and Kishor Padala

Chem. Commun., 2024, 60, 8946
DOI: 10.1039/D4CC02914C

Asymmetric imino-acylation of alkenes enabled by HAT-photo/nickel cocatalysis

Rui Wang and Chuan Wang

Chem. Sci., 2023, 14, 6449
DOI: 10.1039/D3SC01945D

Unleashing the potentiality of metals: synergistic catalysis with light and electricity

Zhengjia Shen, Jia-Lin Tu and Binbin Huang

Org. Chem. Front., 2024, 11, 4024
DOI: 10.1039/D4QO00797B

Dual NHC/photoredox catalytic synthesis of 1,4-diketones using an MR-TADF photocatalyst (DiKTa)

Callum Prentice, James Morrison, Eli Zysman-Colman and Andrew D. Smith

Chem. Commun., 2022, 58, 13624
DOI: 10.1039/D2CC05705K

Photocatalyst-free formate-mediated C–O cleavage by the EDA complex and SCS strategy for the synthesis of diaryl 1,4-diketone in air

Molai Zhao, Yutong Liu, Xueqin Chen, Min Peng, Yawen Wang, Xiangwei Liu, Hezhong Jiang, Rui Tan and Jiahong Li

Org. Biomol. Chem., 2025, 23, 2079
DOI: 10.1039/D4OB01913J

Photoelectrochemical nickel-catalyzed carboacylation/silanoylation of alkenes with unactivated C/Si–H bonds

Lanfen Wang, Xiangyu Huo, Xiaozhi He, Lutz Ackermann and Dingyi Wang

Green Chem., 2024, 26, 8315
DOI: 10.1039/D3GC04109C

Nickel/photo-cocatalyzed three-component silylarylation of electron-deficient alkenes

Pei Fan and Xiao-Xue Huang

Org. Chem. Front., 2025, 12, 4291
DOI: 10.1039/D5QO00346F

Recent advances in three-component radical acylative difunctionalization of unsaturated carbon–carbon bonds

Jiaqiong Sun, Lihong Wang, Guangfan Zheng and Qian Zhang

Org. Chem. Front., 2023, 10, 4488
DOI: 10.1039/D3QO01010D

A TBADT-enabled photo-induced radical cyclization pathway: concise access to functionalized oxindoles

Punith S. Gowda, Duddu S. Sharada and Gedu Satyanarayana

Chem. Commun., 2025, 61, 8391
DOI: 10.1039/D5CC01590A

Ni-catalyzed enantioselective three-component reductive alkylacylation of alkenes: modular access to structurally complex α-amino ketones

Jichao Xiao, Tingting Jia, Shuang Chen, Mengxiao Pan and Xingwei Li

Chem. Sci., 2024, 15, 15489
DOI: 10.1039/D4SC04561K

Visible-Light-Induced Difunctionalization of the C-C Bond of Alkylidenecyclopropanes with Acyl Chlorides

Chuan Ding, Peng-Fei Huang, Biquan Xiong, Ke-Wen Tang and Yu Liu

Catalysts, 2023, 13, 919
DOI: 10.3390/catal13060919

Iron-Mediated Dialkylation of Alkenylarenes with Benzyl Bromides

Daniel M. Lux, Daniel J. Lee, Rishi R. Sapkota and Ramesh Giri

J. Org. Chem., 2024, 89, 16292
DOI: 10.1021/acs.joc.3c02548

Synthesis of α‐Branched Enones via Chloroacylation of Terminal Alkenes

Jungwon Kim, Sven Müller and Tobias Ritter

Angew Chem Int Ed, 2023, 62
DOI: 10.1002/anie.202309498

Photocatalytic Synthesis of β‐Keto Primary Chlorides by Selective Chlorocarbonylation of Olefins

Bitasik Khatua, Anjulika Ghosh, Anuj Kumar Ray, Nayan Banerjee, Jayanta Dey, Ankan Paul and Joyram Guin

Angewandte Chemie, 2024, 136
DOI: 10.1002/ange.202402849

Synergistic Photocatalysis and Hydrogen Atom Transfer Strategy for Acylgermylation of Alkenes

Baobao Ji, Liuzhou Gao, Zhixiang Wang, Yixia Ren and Jia Cao

J. Org. Chem., 2025, 90, 11356
DOI: 10.1021/acs.joc.5c01464

Photocatalytic Synthesis of β‐Keto Primary Chlorides by Selective Chlorocarbonylation of Olefins

Bitasik Khatua, Anjulika Ghosh, Anuj Kumar Ray, Nayan Banerjee, Jayanta Dey, Ankan Paul and Joyram Guin

Angew Chem Int Ed, 2024, 63
DOI: 10.1002/anie.202402849

Asymmetric Alkylative Difunctionalization of Carbon–Carbon Double Bonds by Aliphatic C─H Bond Activation

Zilong Yan, Shang Wang, Xinyu Mao and Dong Xing

ChemCatChem, 2024, 16
DOI: 10.1002/cctc.202401380

Decatungstate-photocatalyzed heterogeneous direct benzylation of N-heterocycles with benzaldehydes

Yan-Yan Zeng, Jun Jiang, Yan-Cui Wen, Chun-Lin Zhuang, Li-Juan Ou, Zi Yang, Hai-Tao Zhu, Zu-Li Wang and Wei-Min He

Chinese Chemical Letters, 2026, 37, 111776
DOI: 10.1016/j.cclet.2025.111776

Ruthenium‐katalysierte entfernte Difunktionalisierung nicht‐aktivierter Alkene für die doppelte meta‐C(sp2)−H/C‐6(sp3)−H‐Funktionalisierung

Shan Chen, Binbin Yuan, Yulei Wang and Lutz Ackermann

Angewandte Chemie, 2023, 135
DOI: 10.1002/ange.202301168

Synthesis of 1,4-Diketones from Esters Enabled by a Tetraborylethane Reagent

Miaomiao Wu, Tongchang Fang, Liangxuan Xu, Qingfeng Xu, Jianmei Lu and Chao Liu

Org. Lett., 2025, 27, 1175
DOI: 10.1021/acs.orglett.4c04690

Strategies and Mechanisms of First-Row Transition Metal-Regulated Radical C–H Functionalization

Xinghua Wang, Jing He, Ya-Nan Wang, Zhenyan Zhao, Kui Jiang, Wei Yang, Tao Zhang, Shiqi Jia, Kangbao Zhong, Linbin Niu and Yu Lan

Chem. Rev., 2024, 124, 10192
DOI: 10.1021/acs.chemrev.4c00188

General Method for Selective Three-Component Carboacylation of Alkenes via Visible-Light Dual Photoredox/Nickel Catalysis

Zi-Kai Wang, Ya-Ping Wang, Zhi-Wu Rao, Chun-Yu Liu, Xian-Hua Pan and Lei Guo

Org. Lett., 2023, 25, 1673
DOI: 10.1021/acs.orglett.3c00307

Selective C(sp3)–H arylation/alkylation of alkanes enabled by paired electrocatalysis

Long Zou, Siqi Xiang, Rui Sun and Qingquan Lu

Nat Commun, 2023, 14
DOI: 10.1038/s41467-023-43791-1

Computational and Mechanistic Studies of Pd-Catalyzed Alkene Carboacylation via Ester C–O Bond Activation

Melisa Alkan, Haley K. Banovetz, Mark S. Gordon and Levi M. Stanley

ACS Catal., 2023, 13, 9766
DOI: 10.1021/acscatal.3c01405

Theoretical Underpinning of Synergetic Ir/Cu-Metallaphotoredox Catalysis in Multicomponent C–N Cross-Coupling Reactions

Manoj V. Mane, Sayan Dutta, Luigi Cavallo and Bholanath Maity

ACS Catal., 2023, 13, 6249
DOI: 10.1021/acscatal.3c00567

Photo‐/Electrocatalytic Difunctionalization of Alkenes Enabled by C−H Radical Functionalization

Zi‐Long Zhou, Yin Zhang, Pei‐Zhe Cui and Jin‐Heng Li

Chemistry A European J, 2024, 30
DOI: 10.1002/chem.202402458

Unified Approach to Diverse Heterocyclic Synthesis: Organo-Photocatalyzed Carboacylation of Alkenes and Alkynes from Feedstock Aldehydes and Alcohols

Vishal Jyoti Roy, Neha Dagar, Swagata Choudhury and Sudipta Raha Roy

J. Org. Chem., 2023, 88, 15374
DOI: 10.1021/acs.joc.3c01884

Ruthenium‐Catalyzed Remote Difunctionalization of Nonactivated Alkenes for Double meta‐C(sp2)−H/C‐6(sp3)−H Functionalization

Shan Chen, Binbin Yuan, Yulei Wang and Lutz Ackermann

Angew Chem Int Ed, 2023, 62
DOI: 10.1002/anie.202301168

α-Acylation of Olefins via Photocatalysis

Hongyu Hou, Yuanyuan Cheng, Bin Chen, Chenho Tung and Lizhu Wu

Chinese Journal of Organic Chemistry, 2023, 43, 1012
DOI: 10.6023/cjoc202211048

Nickel/Photoredox Dual-Catalyzed, Regioselective 1,2-Carboacylation of Alkenes via Synergistic Alkyl and Benzoyl Radical Coupling

Xian-Chen He, Jie Gao, Li Yang, Kai Chen and Hua Yang

Org. Lett., 2025, 27, 4933
DOI: 10.1021/acs.orglett.5c01230

Carbonylative Synthesis of 1,4-Diketones

Zechao Wang and Xiao-Feng Wu

ACS Catal., 2026, 16, 5398
DOI: 10.1021/acscatal.6c00215

Ruthenium-catalyzed alkylarylation of alkenes via para-selective C-H functionalization of unprotected anilines

Xin-Juan Wang, Yao-Hang Cheng, Xin-Yan Lv, Li-Ye Liang, Guang-Hui An and Guang-Ming Li

Chinese Chemical Letters, 2026, 37, 112154
DOI: 10.1016/j.cclet.2025.112154

Ketone Synthesis via Irradiation-Induced Generation of a Persistent Ketyl Radical from Acyl Azolium Salts

Shihao Li, Chenglong Zheng, Sheng Wang, Xiao-Xuan Li, Qi Zhang, Shilu Fan and Yi-Si Feng

Org. Lett., 2023, 25, 6522
DOI: 10.1021/acs.orglett.3c02300

Selective Functionalization of C(sp3)—H Bonds via Photoredox/ Nickel Dual Catalysis

Xiaoqin Wang, Sheng Xu, Yuanyuan Ping and Wangqing Kong

Chinese Journal of Organic Chemistry, 2025, 45, 383
DOI: 10.6023/cjoc202406036

Visible Light Induced Three‐Component 1,2‐Dicarbofunctionalization of Alkenes and Alkynes

Mrittika Mohar, Sumit Ghosh and Alakananda Hajra

The Chemical Record, 2023, 23
DOI: 10.1002/tcr.202300121

Revealing Catalyst Self-Adjustment in C–S Cross-Coupling through Multiscale Liquid-Phase Electron Microscopy

Alexey S. Kashin, Daria M. Arkhipova, Liliya T. Sahharova, Julia V. Burykina and Valentine P. Ananikov

ACS Catal., 2024, 14, 5804
DOI: 10.1021/acscatal.3c06258

Nickel-catalyzed reductive formylation of aryl halides via formyl radical

Xiao-Bo Liu, Ren-Ming Liu, Xiao-Di Bao, Hua-Jian Xu, Qi Zhang and Yu-Feng Liang

Chinese Chemical Letters, 2024, 35, 109783
DOI: 10.1016/j.cclet.2024.109783

Nickel/photoredox dual catalyzed arylalkylation of nonactivated alkenes

Yuxi Gao, Lijuan Gao, Endiao Zhu, Yunhong Yang, Mi Jie, Jiaqian Zhang, Zhiqiang Pan and Chengfeng Xia

Nat Commun, 2023, 14
DOI: 10.1038/s41467-023-43748-4

TBADT/nickel co-catalyzed three-component radical acylarylation of alkenes with aldehydes and aryl iodides

Zilong Yan, Feifei Chen, Yong Lu, Zhaolin Fu, Weiping Zheng, Shuanhu Gao, Fan Yang, Jie Tang, Ming-Liang Ma and Dong Xing

Green Synthesis and Catalysis, 2025
DOI: 10.1016/j.gresc.2025.10.002

Recent Advances in Photochemical Asymmetric Three‐Component Reactions

Haichao Huang, Yu‐Mei Lin and Lei Gong

The Chemical Record, 2023, 23
DOI: 10.1002/tcr.202300275

Recent Advances in Nonprecious Metal Catalysis

Michael C. Haibach, Shashank Shekhar, Tonia S. Ahmed and Andrew R. Ickes

Org. Process Res. Dev., 2023, 27, 423
DOI: 10.1021/acs.oprd.2c00344

Copper-Catalyzed Asymmetric Carbocyanation of 1,3-Dienes and Vinylarenes with Simple Aldehydes and Alkanes

Shang Wang, Xiangwen Zhu, Si-Cong Chen and Dong Xing

ACS Catal., 2025, 15, 15475
DOI: 10.1021/acscatal.5c04586

Multicomponent Reaction of Aliphatic Organozinc Reagents, Acrylates and Acyl chlorides: Synthesis of α‐Substituted β‐Ketoesters

Marine Pinaud, Walid Baba Hamed, Marc Presset and Erwan Le Gall

Adv Synth Catal, 2023, 365, 2877
DOI: 10.1002/adsc.202300540

Nickel/Photo-Cocatalyzed Three-Component Alkyl-Acylation of Aryl-Activated Alkenes

Pei Fan, Zhe Chen and Chuan Wang

Org. Lett., 2023, 25, 8877
DOI: 10.1021/acs.orglett.3c03669

Decatungstate‐Catalyzed Carbon‐Carbon Bond Formation Between Furfural and Electron‐Deficient Olefins

Emil Krogh Nielsen, Kassem El‐Chami, Clara Mondrup de Lichtenberg and Robert Madsen

Eur J Org Chem, 2024, 27
DOI: 10.1002/ejoc.202400109

Synthesis of α‐Branched Enones via Chloroacylation of Terminal Alkenes

Jungwon Kim, Sven Müller and Tobias Ritter

Angewandte Chemie, 2023, 135
DOI: 10.1002/ange.202309498

Ni-Catalyzed Regioselective Alkylarylation of Unactivated Alkenes in Amines Enabled by Cooperative Ligand Effects of Nitriles and Electron-Deficient Alkenes

Vivek Aryal, Supuni I. N. Hewa Inaththappulige, Ayush Acharya and Ramesh Giri

J. Am. Chem. Soc., 2025, 147, 1667
DOI: 10.1021/jacs.4c12334

Advances in Nickel-Metallaphotoredox Catalysis in Organic Synthesis: A New Approach to Targeted Reaction Design

Susmita Podder

COC, 2026, 30, 303
DOI: 10.2174/0113852728378634250618190946

Amines tuned controllable carbonylation for the synthesis of γ-lactones and 1,4-diones

Yuanrui Wang, Youzhi Xu, Xin Qi, Le-Cheng Wang, Chao Xu, Genping Huang and Xiao-Feng Wu

Nat Commun, 2025, 16
DOI: 10.1038/s41467-025-61762-6

Carbon monoxide enabling synergistic carbonylation and (hetero)aryl migration

Yuanrui Wang, Hefei Yang, Yan Zheng, Mingxia Hu, Jintao Zhu, Zhi-Peng Bao, Yanying Zhao and Xiao-Feng Wu

Nat Catal, 2024, 7, 1065
DOI: 10.1038/s41929-024-01204-6