Structure–effect relationship studies of polysaccharides based on receptor–active centres: an alternative view

Wenjin Zhang, Xiaojia Zhang, Qiuxian Bai, Le Liang, Sheng Wang and Lanping Guo

Food Funct., 2023, 14, 4981
DOI: 10.1039/D2FO03702E

Surface morphology and action mechanism of macrophage immunostimulating activity of Rosa Setate x Rosa Rugosa polysaccharide WSRP-1b

Mengqi Wu, Jingying Xu, Wei Li, Qifeng Han, Wei Xia, Zhong Li, Yang Zhang and Wenqing Zhang

Carbohydrate Polymer Technologies and Applications, 2023, 6, 100339
DOI: 10.1016/j.carpta.2023.100339

A bioactive polysaccharide derived from Rosa laevigata fruits: Structural properties, antitumor efficacy, and potential mechanisms

Xiaoyang Guo, Fan Nie, Haojing Jiang, Sitong Che, Hai-bing Liao, Jing Xu and Yuanqiang Guo

International Journal of Biological Macromolecules, 2025, 304, 140382
DOI: 10.1016/j.ijbiomac.2025.140382

Gas chromatography (GC) fingerprinting and immunomodulatory activity of polysaccharide from the rhizome of Menispermum dauricum DC

Pei Yang, Yang Zhai, Yan Ma, Beibei Mao, Fengshan Wang, Li Li, Lijuan Luan and Yuhong Liu

PeerJ, 2022, 10, e13946
DOI: 10.7717/peerj.13946

The kinetic study on key quality and microbial content of fresh-cutting Chinese yams (Dioscorea opposita Thunb.) at different storage temperatures

Zhiyao Li, Youqing Wen, Yueling Yan, Ying Ning, Maomei Xie, Yiting Zhu and Haixia Wang

Journal of Stored Products Research, 2024, 105, 102251
DOI: 10.1016/j.jspr.2024.102251

Structural characterization and immunomodulatory activity of an exopolysaccharide from marine-derived Aspergillus versicolor SCAU141

Keyue Wu, Yiyang Li, Yuqi Lin, Baojun Xu, Jiajia Yang, Li Mo, Riming Huang and Xiaoyong Zhang

International Journal of Biological Macromolecules, 2023, 227, 329
DOI: 10.1016/j.ijbiomac.2022.12.127

Chinese yam polysaccharides PLGA-stabilized Pickering emulsion as an adjuvant system for PCV- 2 vaccine to enhance immune response

Yue Zhang, Pengfei Gu, Lina Jiao, Jin He, Lin Yu, Zhenguang Liu, Yang Yang, Yuanliang Hu, Jiaguo Liu and Deyun Wang

International Journal of Biological Macromolecules, 2022, 219, 1034
DOI: 10.1016/j.ijbiomac.2022.08.035

Immunoregulatory activity of an alkaline-precipitated polysaccharide CGP-AP produced by Chaetomium globosum CGMCC 6882

Shuaiyang Wang, Na Li, Ye Zhang, Xueyan Zhou, Renyong Zhao, Minjie Gao, Zhitao Li, Lemei An, Zichao Wang and Shaobo Duan

Carbohydrate Polymer Technologies and Applications, 2024, 7, 100430
DOI: 10.1016/j.carpta.2024.100430

Ilex asprella-derived polysaccharide activates macrophage via TLR4-mediated NF-κB and MAPK signaling pathways

Yao Wang, Lijing Ye, Ruikun Yan, Chuangchuang Guo, Miaohui Mu, Yuxuan Sun, Haibo Zhou and Guojun Zhao

Journal of Functional Foods, 2024, 122, 106527
DOI: 10.1016/j.jff.2024.106527

Natural vaccine adjuvants from traditional Chinese medicines: Mechanisms to applications

Xiaoyuan Fan, Fengxiang Liu, Fei Sun, Yiyang Wang, Wenwen Shen, Shujun Wang, Jin Sun and Kaiyuan Wang

Acta Pharmaceutica Sinica B, 2025
DOI: 10.1016/j.apsb.2025.06.021

Effects of Low Molecular Weight Peptides from Red Shrimp (Solenocera crassicornis) Head on Immune Response in Immunosuppressed Mice

Rui Zhao, Shuoqi Jiang, Yunping Tang and Guofang Ding

IJMS, 2023, 24, 10297
DOI: 10.3390/ijms241210297

Fucoidan from Apostichopus japonicus enhances intestinal barrier function and promotes intestinal immunity via regulating the gut microbiota and tryptophan metabolism

Wanting Qin, Biqian Wei, Pengfei Ren, Yaoguang Chang, Changhu Xue and Qingjuan Tang

International Journal of Biological Macromolecules, 2025, 301, 139929
DOI: 10.1016/j.ijbiomac.2025.139929

The polysaccharide from Aralia continentalis Kitagawa enhances immune responses via activating the MAPKs and NF-κB signaling pathways in RAW 264.7 macrophages

Xi Wang, Liyang Liu, Xu Zhang, Di Xie, Hewen Hu, Siqi Wang, Dawei Wang and Tianyu Wang

Chem. Biol. Technol. Agric., 2024, 11
DOI: 10.1186/s40538-024-00649-y

Dioscoreae Rhizoma starch improves chronic diarrhea by regulating the gut microbiotas and fecal metabolome in rats

Qing Zhang, Xu Zhang, Qing Wang and Suiqing Chen

Food Science & Nutrition, 2023, 11, 6271
DOI: 10.1002/fsn3.3567

Exploration of in vitro digestive, antioxidative, and anti-inflammatory benefits of yam (Dioscorea rhizoma) powder-enriched noodles

Feng Jia, Zhihang Qiao, Lei Zeng, Zuchong Liu, Haifeng Li and Jikai Zhao

Grain & Oil Science and Technology, 2025, 8, 192
DOI: 10.1016/j.gaost.2025.06.001

Immunomodulatory activity and mechanism of Chinese yam polysaccharide after sulfated modification

Xianxiang Chen, Shihua Wu, Rong Huang, Xuan Liu, Mingyue Shen and Jianhua Xie

Industrial Crops and Products, 2023, 197, 116549
DOI: 10.1016/j.indcrop.2023.116549

Immunomodulatory natural polysaccharide‐based nanoparticles for the treatment of neurodegenerative diseases

Leto‐Aikaterini Tziveleka, Mariafrancesca Cascione, Paolo Pellegrino, Annalisa Bianco, Stefano Leporatti and Valeria De Matteis

Ibrain, 2025
DOI: 10.1002/ibra.12199

Immunomodulatory mechanism of Radix Bupleuri polysaccharide on RAW264.7 cells and cyclophosphamide-induced immunosuppressed mice

Xueyan Wu, Jun Peng, Chunyu Zhang, Yifan Liao, Xinran Zhang, Yilin Hou, Tiantang Fan, Tianyun Fan and Jigang Wang

International Journal of Biological Macromolecules, 2025, 327, 147092
DOI: 10.1016/j.ijbiomac.2025.147092

Prospects of yam (Dioscorea) polysaccharides: Structural features, bioactivities and applications

Luyao Zhang, Shirui Wang, Weimei Zhang, Guanglu Chang, Lanping Guo, Xia Li and Wenyuan Gao

Food Chemistry, 2024, 446, 138897
DOI: 10.1016/j.foodchem.2024.138897

Acidic polysaccharide CP-2 from Dioscoreae Rhizoma ameliorated acute alcoholic liver injury through the gut-liver axis and AMPK/PPAR pathway

Yujun Xie, Mingxing Tao, Xiaodong Yan, Xinxin Fan, Alamusi Bayoude, Yu Lu, Shuangli Zhao, Boyang Yu and Renshi Li

International Journal of Biological Macromolecules, 2025, 310, 143145
DOI: 10.1016/j.ijbiomac.2025.143145

Sulfated modification, characterizations, anti-oxidant and immunostimulatory activities of a polysaccharide from Arnebia euchroma (Royle) Johnst. Roots

Man Zhang, Peng Zhao, Sarangua Ochir, Wenming Bai, Jingkun Lu, Mu Dan, Surina Bo and Chen Chen

Results in Chemistry, 2025, 17, 102624
DOI: 10.1016/j.rechem.2025.102624

Sulfated Chinese Yam Polysaccharides Alleviate LPS-Induced Acute Inflammation in Mice through Modulating Intestinal Microbiota

Shihua Wu, Xianxiang Chen, Ruixin Cai, Xiaodie Chen, Jian Zhang, Jianhua Xie and Mingyue Shen

Foods, 2023, 12, 1772
DOI: 10.3390/foods12091772

Unveiling the immunomodulatory mechanism of polysaccharides from Polygonum cyrtonema based on RNA-seq

Jialuo Shan, Wenjie Ma, Yue Guo, Xinxin Chang, Jianhua Xie, Yi Chen, Xiaobo Hu and Qiang Yu

Food Research International, 2024, 175, 113755
DOI: 10.1016/j.foodres.2023.113755

Protection effect of Dioscoreae Rhizoma against ethanol-induced gastric injury in vitro and in vivo: A phytochemical and pharmacological study

Yujun Xie, Luyao An, Xiaoyan Wang, Yajie Ma, Alamusi Bayoude, Xinxin Fan, Boyang Yu and Renshi Li

Journal of Ethnopharmacology, 2024, 333, 118427
DOI: 10.1016/j.jep.2024.118427

Structural characterization of galactomannan sulfated modification products with different molecular weight fractions and their in vitro anti-lung cancer activities

Ying Lv, Yubo Zhou, Ziyi Jin, Chenhuan Lai, Yanan Chen and Qiang Yong

International Journal of Biological Macromolecules, 2025, 315, 144326
DOI: 10.1016/j.ijbiomac.2025.144326

Syzygium aromaticum enhances innate immunity by triggering macrophage M1 polarization and alleviates Helicobacter pylori-induced inflammation

Chang Peng, Zhong Feng, Ling Ou, Yuanjing Zou, Shuyi Sang, Hengrui Liu, Weixing Zhu, Guoxing Gan, Guimin Zhang and Meicun Yao

Journal of Functional Foods, 2023, 107, 105626
DOI: 10.1016/j.jff.2023.105626

Research progress on the structure, derivatives, pharmacological activity, and drug carrier capacity of Chinese yam polysaccharides: A review

Yuanyuan Guo, Fangrui Liu, Jin Zhang, Jing Chen, Wenxiao Chen, Yongjian Hong, Jinghong Hu and Qian Liu

International Journal of Biological Macromolecules, 2024, 261, 129853
DOI: 10.1016/j.ijbiomac.2024.129853

Molecular Insights into the Macrophage Immunomodulatory Effects of Scrophulariae Radix Polysaccharides

Ming Zhao, Sichun Zheng, Mengyu Wang, Jiahui Wu, Xiaodan Ma and Wei Xu

Chemistry & Biodiversity, 2023, 20
DOI: 10.1002/cbdv.202301180

Preparation methods, structural features, biological activities and potential applications of Ophiopogon japonicus polysaccharides: An updated review

Tongtong Zhu, Yi Wang, Ju Liu, Lei Zhang, Yujie Dai, Dandan Xu and Zepeng Zhang

International Journal of Biological Macromolecules, 2025, 290, 139059
DOI: 10.1016/j.ijbiomac.2024.139059

Structural Characterization and Anti-Nonalcoholic Fatty Liver Effect of High-Sulfated Ulva pertusa Polysaccharide

Yuzhou Wan, Lin Liu, Bo Zhang, Shaopeng Wang, Xiaoqian Wang, Kexu Chen, Yuxi Li, Tingting Zhao and Huimin Qi

Pharmaceuticals, 2022, 16, 62
DOI: 10.3390/ph16010062

Propolis-loaded nanostructured lipid carriers halt breast cancer progression through miRNA-223 related pathways: an in-vitro/in-vivo experiment

Sara A. Shaker, Shadi M. Alshufta, Mennatallah A. Gowayed, Noha S. El-Salamouni, Samar M. Bassam, Magda A. Megahed and Rasha A. El-Tahan

Sci Rep, 2023, 13
DOI: 10.1038/s41598-023-42709-7

Chinese yam polysaccharide enhances anti-PD-1 immunotherapy in colorectal cancer through alterations in the gut microbiota and metabolites

Guangtao Zhang, Jiashu Pan, Xiangyuan Xu, Shuchang Nie, Lu Lu, Yanhua Jing, Fan Yang, Guang Ji and Hanchen Xu

International Journal of Biological Macromolecules, 2025, 310, 143323
DOI: 10.1016/j.ijbiomac.2025.143323

Immunomodulatory Effect of Cordyceps militaris Polysaccharide on RAW 264.7 Macrophages by Regulating MAPK Signaling Pathways

Yan Liu, Jiayi Yang, Zhijian Guo, Qizhang Li, Lida Zhang, Lingxia Zhao and Xuanwei Zhou

Molecules, 2024, 29, 3408
DOI: 10.3390/molecules29143408

Structural characterization and combined immunomodulatory activity of fermented Chinese yam polysaccharides with probiotics

Yahui Yang, Ziru Lai, Xilei Hu, Peiyao Zhang, Yang Zhang, Yi Zheng, Li Ding, Jiaqi Wang, Na Li, Zichao Wang, Lemei An and Yi Ding

International Journal of Biological Macromolecules, 2025, 307, 142290
DOI: 10.1016/j.ijbiomac.2025.142290

Purification, Structural Characterization, and Immunomodulatory Activity of an Exopolysaccharide from Acetilactobacillus jinshanensis BJ01 in Baijiu Fermentation Grains

Tian Tian, Bo Wan, Ying Xiong, Han Wang, Yuanyuan An, Ruijie Gao, Pulin Liu, Mingchun Zhang, Lihong Miao and Weifang Liao

Foods, 2025, 14, 2162
DOI: 10.3390/foods14132162

The effects of Yam polysaccharides on acrylamide-induced RAW264.7 cell polarization

Aoni Zhang, Dongliang Jin, Ying Han, Jiankang Wang and Jing Wang

Journal of Food Bioactives, 2023, 35
DOI: 10.31665/JFB.2023.18352

Natural resourced polysaccharides: Preparation, purification, structural elucidation, structure-activity relationships and regulating intestinal flora, a system review

Di Han, Le Yang, Qichao Liang, Hui Sun, Ye Sun, Guangli Yan, Xiwu Zhang, Ying Han, Xiaoyu Wang and Xijun Wang

International Journal of Biological Macromolecules, 2024, 280, 135956
DOI: 10.1016/j.ijbiomac.2024.135956

Novel immunomodulatory peptides from hydrolysates of the Rana spinosa (Quasipaa spinosa) meat and their immunomodulatory activity mechanism

Yan Zeng, Hongyi Cheng, Ruimin Zhong, Wanying Zhong, Rongquan Zheng and Jianyin Miao

Food Chemistry, 2025, 465, 142024
DOI: 10.1016/j.foodchem.2024.142024

Overview of the Study on the Mechanism of Influence of Jianling Decoction Formula Monomer on Hypertension

建英袁

ACM, 2024, 14, 928
DOI: 10.12677/acm.2024.1482303

Immunomodulatory activity and molecular mechanisms of action of peptides derived from casein hydrolysate by alcalase and flavourzyme based on virtual screening

Yutong Jiang, Siyi Li, Lai Jiang, Guangqing Mu and Shujuan Jiang

Journal of Dairy Science, 2025, 108, 2152
DOI: 10.3168/jds.2024-25224

Chemical Modification, Characterization, and Activity Changes of Land Plant Polysaccharides: A Review

Zhi-Wei Li, Zhu-Mei Du, Ya-Wen Wang, Yu-Xi Feng, Ran Zhang and Xue-Bing Yan

Polymers, 2022, 14, 4161
DOI: 10.3390/polym14194161

Immunostimulatory effects mechanism of polysaccharide extracted from Acanthopanax senticosus on RAW 264.7 cells through activating the TLR/MAPK/NF-κB signaling pathway

Yufan Wang, Lei Wang, Hanwen Zhang, Peirou Ren, Xiaowen Cheng, Fandi Hong, Jiaxin Liu, Ruining Zhang, Jun Zhao and Dongxia Gou

Sci Rep, 2025, 15
DOI: 10.1038/s41598-025-97423-3

Sulfated Chinese yam polysaccharide exert anti‐inflammatory potential via MAPK/NF‐κB signaling pathways in a co‐culture system and LPS‐induced acute inflammatory mice model

Xianxiang Chen, Shihua Wu, Xin Tao, Fengxia He and Mingyue Shen

Journal of Food Science, 2024, 89, 6720
DOI: 10.1111/1750-3841.17319

Immunomodulatory Effect of Benincasa hispida Extract Fermented by Bacillus subtilis CJH 101 on RAW 264.7 Macrophages

Ye Eun Choi, Jung Mo Yang, Chae Won Jeong, He Seung Hur and Ju Hyun Cho

Fermentation, 2023, 9, 701
DOI: 10.3390/fermentation9080701

Research progress on extraction, structure, bioactivity, structure-activity relationship and product applications of polysaccharides from Mori Fructus

Yong-Shuai Jing, Jin-Ying Hu, Zi-Ying Wang, Cheng Tao, Shi-Lin Zhang, Bei-Bei Hu and Zhi-Wei Li

Food & Medicine Homology, 2025, 2, 9420067
DOI: 10.26599/FMH.2025.9420067