Honeycomb scaffolds capable of achieving barrier membrane-free guided bone regeneration

Koichiro Hayashi, Masaya Shimabukuro, Ryo Kishida, Akira Tsuchiya and Kunio Ishikawa

Mater. Adv., 2021, 2, 7638
DOI: 10.1039/D1MA00698C

Novel insights into nanomaterials for immunomodulatory bone regeneration

Ya Cui, Hairui Li, Yaxin Li and Lixia Mao

Nanoscale Adv., 2022, 4, 334
DOI: 10.1039/D1NA00741F

Impacts of channel direction on bone tissue engineering in 3D-printed carbonate apatite scaffolds

Koichiro Hayashi, Nao Kato, Masaki Kato and Kunio Ishikawa

Materials & Design, 2021, 204, 109686
DOI: 10.1016/j.matdes.2021.109686

Honeycomb Scaffold: Effects of Microstructure on Bone Regeneration and Applications to Orthopedic and Dental Fields

Koichiro Hayashi

Funtai Kogakkaishi, 2021, 58, 613
DOI: 10.4164/sptj.58.613

Effects of Scaffold Shape on Bone Regeneration: Tiny Shape Differences Affect the Entire System

Koichiro Hayashi, Toshiki Yanagisawa, Ryo Kishida and Kunio Ishikawa

ACS Nano, 2022, 16, 11755
DOI: 10.1021/acsnano.2c03776

Fabrication and histological evaluation of a self-setting granular cement using calcium sulfate hemihydrate granules with different pore distribution

Luis Miguel TORRES ESCALANTE, Akira TSUCHIYA, Lou ZHANRUI, Miki MORINOBU and Kunio ISHIKAWA

Dent. Mater. J., 2024, 43, 573
DOI: 10.4012/dmj.2023-248

Antibacterial and Angiogenic Copper Phosphate-Modified Carbonate Apatite Honeycomb Plugs for Enhanced Gingival and Alveolar Bone Regeneration

Koichiro Hayashi, Eri Teramoto, Ahmad Nazir Taleb Alashkar, Zhanrui Lou, Masafumi Moriyama and Kunio Ishikawa

ACS Appl. Mater. Interfaces, 2025, 17, 33340
DOI: 10.1021/acsami.5c01022

Electrospun Poly(butylene-adipate-co-terephthalate)/Nano-hyDroxyapatite/Graphene Nanoribbon Scaffolds Improved the In Vivo Osteogenesis of the Neoformed Bone

Luana Marotta Reis Vasconcellos, Gabriela F. Santana-Melo, Edmundo Silva, Vanessa Fernandes Pereira, Juliani Caroline Ribeiro Araújo, André Diniz Rosa Silva, André S. A. Furtado, Conceição de Maria Vaz Elias, Bartolomeu Cruz Viana, Fernanda Roberta Marciano and Anderson Oliveira Lobo

JFB, 2021, 12, 11
DOI: 10.3390/jfb12010011

Reconstruction of Load-Bearing Segmental Bone Defects Using Carbonate Apatite Honeycomb Blocks

Keigo Shibahara, Koichiro Hayashi, Yasuharu Nakashima and Kunio Ishikawa

ACS Mater. Au, 2023, 3, 321
DOI: 10.1021/acsmaterialsau.3c00008

Formulation and Characterization of Chitosan-Based Mixed-Matrix Scaffold for Tissue Engineering

Rita Lopes, Paulo M. Gordo, Benilde F. O. Costa and Patrícia Alves

Macromol, 2024, 4, 253
DOI: 10.3390/macromol4020014

Reconstruction of critical‐size segmental defects in rat femurs using carbonate apatite honeycomb scaffolds

Yuta Sakemi, Koichiro Hayashi, Akira Tsuchiya, Yasuharu Nakashima and Kunio Ishikawa

J Biomedical Materials Res, 2021, 109, 1613
DOI: 10.1002/jbm.a.37157

Antibacterial Honeycomb Scaffolds for Achieving Infection Prevention and Bone Regeneration

Koichiro Hayashi, Masaya Shimabukuro and Kunio Ishikawa

ACS Appl. Mater. Interfaces, 2022, 14, 3762
DOI: 10.1021/acsami.1c20204

Gear-shaped carbonate apatite granules with a hexagonal macropore for rapid bone regeneration

Koichiro Hayashi, Toshiki Yanagisawa, Ryo Kishida, Akira Tsuchiya and Kunio Ishikawa

Computational and Structural Biotechnology Journal, 2023, 21, 2514
DOI: 10.1016/j.csbj.2023.03.053

Honeycomb scaffolds capable of ectopic osteogenesis: Histological evaluation of osteoinduction mechanism

Koichiro Hayashi and Kunio Ishikawa

Nano Select, 2022, 3, 60
DOI: 10.1002/nano.202000283

Development and assessment of modified-honeycomb-structure scaffold for bone tissue engineering

Rigoberto Lopez Reyes, Min-Soo Ghim, Nae-Un Kang, Ji-Woo Park, So-Jung Gwak and Young-Sam Cho

Additive Manufacturing, 2022, 54, 102740
DOI: 10.1016/j.addma.2022.102740

Endowing osseointegration ability to bioinert alumina by carbonate apatite coating

Koichiro Hayashi and Kunio Ishikawa

Surfaces and Interfaces, 2023, 36, 102617
DOI: 10.1016/j.surfin.2022.102617

Strategic Uniaxial Macropore Sizing for Honeycomb-Structured Scaffolds for Enhanced Bone Reconstruction in Segmental Bone Defects

Keigo Shibahara, Koichiro Hayashi, Yasuharu Nakashima and Kunio Ishikawa

ACS Omega, 2025
DOI: 10.1021/acsomega.4c11634

Channel Aperture Characteristics of Carbonate Apatite Honeycomb Scaffolds Affect Ingrowths of Bone and Fibrous Tissues in Vertical Bone Augmentation

Koichiro Hayashi, Ryo Kishida, Akira Tsuchiya and Kunio Ishikawa

Bioengineering, 2022, 9, 627
DOI: 10.3390/bioengineering9110627

Fabrication of magnesium-doped biphasic calcium phosphate granules with sea urchin spine-derived porous structure

Muhammad Amir Jamilludin, Koichiro Hayashi, Yusril Yusuf and Kunio Ishikawa

Ceramics International, 2024, 50, 25988
DOI: 10.1016/j.ceramint.2024.04.341

Carbonate Apatite Honeycomb Scaffold-Based Drug Delivery System for Repairing Osteoporotic Bone Defects

Koichiro Hayashi, Cheng Zhang, Ahmad Nazir Taleb Alashkar and Kunio Ishikawa

ACS Appl. Mater. Interfaces, 2024, 16, 45956
DOI: 10.1021/acsami.4c08047

Lamellar Septa-like Structured Carbonate Apatite Scaffolds with Layer-by-Layer Fracture Behavior for Bone Regeneration

Ahmad Nazir Taleb Alashkar, Koichiro Hayashi and Kunio Ishikawa

Biomimetics, 2024, 9, 112
DOI: 10.3390/biomimetics9020112

Structurally optimized honeycomb scaffolds with outstanding ability for vertical bone augmentation

Koichiro Hayashi, Masaya Shimabukuro, Ryo Kishida, Akira Tsuchiya and Kunio Ishikawa

Journal of Advanced Research, 2022, 41, 101
DOI: 10.1016/j.jare.2021.12.010

Effects of pH on the microarchitecture of carbonate apatite granules fabricated through a dissolution–precipitation reaction

Zhibin Wang, Masaya Shimabukuro, Ryo Kishida, Taishi Yokoi and Masakazu Kawashita

Front. Bioeng. Biotechnol., 2024, 12
DOI: 10.3389/fbioe.2024.1396275

Honeycomb Scaffold-Guided Bone Reconstruction of Critical-Sized Defects in Rabbit Ulnar Shafts

Keigo Shibahara, Koichiro Hayashi, Yasuharu Nakashima and Kunio Ishikawa

ACS Appl. Bio Mater., 2021, 4, 6821
DOI: 10.1021/acsabm.1c00533

Effects of pore interconnectivity on bone regeneration in carbonate apatite blocks

Maab Elsheikh, Ryo Kishida, Koichiro Hayashi, Akira Tsuchiya, Masaya Shimabukuro and Kunio Ishikawa

Regenerative Biomaterials, 2022, 9
DOI: 10.1093/rb/rbac010

Strategies to Improve Bone Healing: Innovative Surgical Implants Meet Nano-/Micro-Topography of Bone Scaffolds

Dirk Wähnert, Johannes Greiner, Stefano Brianza, Christian Kaltschmidt, Thomas Vordemvenne and Barbara Kaltschmidt

Biomedicines, 2021, 9, 746
DOI: 10.3390/biomedicines9070746

Irregular pore size of degradable bioceramic Voronoi scaffolds prepared by stereolithography: Osteogenesis and computational fluid dynamics analysis

Jialiang Li, Dong Guo, Jie Li, Xinyu Wei, Zhongwei Sun, Baohui Yang, Teng Lu, Pengrong Ouyang, Su'e Chang, Weiwei Liu and Xijing He

Materials & Design, 2022, 224, 111414
DOI: 10.1016/j.matdes.2022.111414

Low‐crystalline magnesium‐doped carbonate apatite/β‐tricalcium phosphate granules from sea urchin spine

Muhammad Amir Jamilludin, Koichiro Hayashi, Yusril Yusuf and Kunio Ishikawa

J Am Ceram Soc., 2025, 108
DOI: 10.1111/jace.20498

Large three-dimensional cell constructs for tissue engineering

Jun-Ichi Sasaki, Gabriela L Abe, Aonan Li, Takuya Matsumoto and Satoshi Imazato

Science and Technology of Advanced Materials, 2021, 22, 571
DOI: 10.1080/14686996.2021.1945899

Monolithic copper-doped carbonated apatite synthesized at low-temperature exhibits in vitro antibacterial effect and in vivo bone regenerative properties

Pery Freitas, Janice Lay Tin Tan and Kunio Ishikawa

Materialia, 2025, 42, 102441
DOI: 10.1016/j.mtla.2025.102441

Superiority of Triply Periodic Minimal Surface Gyroid Structure to Strut-Based Grid Structure in Both Strength and Bone Regeneration

Koichiro Hayashi, Ryo Kishida, Akira Tsuchiya and Kunio Ishikawa

ACS Appl. Mater. Interfaces, 2023, 15, 34570
DOI: 10.1021/acsami.3c06263

Biocompatibility and Bone Regeneration by Shape Memory Polymer Scaffolds

Shelby B. Gasson, Lauren K. Dobson, Michaela R. Pfau‐Cloud, Felipe O. Beltran, Roy R. Pool, Carl A. Gregory, Melissa A. Grunlan and W. Brian Saunders

J Biomedical Materials Res, 2025, 113
DOI: 10.1002/jbm.a.37806

Granular honeycomb scaffolds composed of carbonate apatite for simultaneous intra- and inter-granular osteogenesis and angiogenesis

Koichiro Hayashi, Toshiki Yanagisawa, Masaya Shimabukuro, Ryo Kishida and Kunio Ishikawa

Materials Today Bio, 2022, 14, 100247
DOI: 10.1016/j.mtbio.2022.100247

Multiscale porous scaffolds constructed of carbonate apatite honeycomb granules for bone regeneration

Koichiro Hayashi, Akira Tsuchiya, Masaya Shimabukuro and Kunio Ishikawa

Materials & Design, 2022, 215, 110468
DOI: 10.1016/j.matdes.2022.110468

Honeycomb Scaffolds Fabricated Using Extrusion Molding and the Sphere-Packing Theory for Bone Regeneration

Koichiro Hayashi and Kunio Ishikawa

ACS Appl. Bio Mater., 2021, 4, 721
DOI: 10.1021/acsabm.0c01279

Comparison of calcite and vaterite as precursors for CO3Ap artificial bone fabrication through a dissolution–precipitation reaction

Keisuke Tanaka, Akira Tsuchiya, Yoichiro Ogino, Yasunori Ayukawa and Kunio Ishikawa

Ceramics International, 2022, 48, 26425
DOI: 10.1016/j.ceramint.2022.05.336

Biomanufacturing in Japan: frontier research from 2018 to 2023

Qing Cao, Yangqianhui Zhang, Runyi Deng, Kai Ren, Huayong Yang and Dong Han

Bio-des. Manuf., 2023, 6, 617
DOI: 10.1007/s42242-023-00261-3

Hematopoietic Function Restoration by Transplanting Bone Marrow Niches In Vivo Engineered Using Carbonate Apatite Honeycomb Bioreactors

Koichiro Hayashi, Ryo Kishida, Akira Tsuchiya and Kunio Ishikawa

Small Structures, 2024, 5
DOI: 10.1002/sstr.202400065

Natural bone-mimicking nanopore-incorporated hydroxyapatite scaffolds for enhanced bone tissue regeneration

Chansong Kim, Jin Woong Lee, Jun Hyuk Heo, Cheolhyun Park, Dai-Hwan Kim, Gyu Sung Yi, Ho Chang Kang, Hyun Suk Jung, Hyunjung Shin and Jung Heon Lee

Biomater Res, 2022, 26
DOI: 10.1186/s40824-022-00253-x

Effects of Channels and Micropores in Honeycomb Scaffolds on the Reconstruction of Segmental Bone Defects

Keigo Shibahara, Koichiro Hayashi, Yasuharu Nakashima and Kunio Ishikawa

Front. Bioeng. Biotechnol., 2022, 10
DOI: 10.3389/fbioe.2022.825831

Fabrication of highly interconnected porous carbonate apatite blocks based on the setting reaction of calcium sulfate hemihydrate granules

Ryo Kishida, Maab Elsheikh, Koichiro Hayashi, Akira Tsuchiya and Kunio Ishikawa

Ceramics International, 2021, 47, 19856
DOI: 10.1016/j.ceramint.2021.03.324

Effects of Space Dimensionality within Scaffold for Bone Regeneration with Large and Oriented Blood Vessels

Koichiro Hayashi, Ryo Kishida, Akira Tsuchiya and Kunio Ishikawa

Materials, 2023, 16, 7518
DOI: 10.3390/ma16247518