Gastrointestinal digestion of dietary advanced glycation endproducts increases their pro-inflammatory potential

T. van der Lugt, M. F. Vrolijk, T. F. H. Bovee, S. P. J. van Leeuwen, S. Vonsovic, A. Hamers, A. Opperhuizen and A. Bast

Food Funct., 2021, 12, 6691
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Parallel generation of extra advanced glycation end-products during co-digestion of whey proteins and α-dicarbonyls in a simulated gastrointestinal model

Qiaozhi Zhang, Yuhao Jiang, Huatao Li, Zhongshan Gao, Gang Yu, Hujun Xie, Yanbo Wang and Linglin Fu

Food Funct., 2023, 14, 5342
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Advances in static in vitro digestion models after the COST action Infogest consensus protocol

Raffaella Colombo, Lucia Ferron, Ilaria Frosi and Adele Papetti

Food Funct., 2021, 12, 7619
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The effects of different thermal processing methods on the protein structure and digestibility of Procambarus clarkii

Xuan Liu, Chuanfeng Hu, TianYu Xiao, Liu Du, Ziyi Tu, Wei Yu and Yu Qiao

Food Funct., 2025, 16, 3591
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Co-encapsulation of probiotics with functional components: design strategies, synergistic mechanisms, biomedical applications, and challenges for industrialization

Chenyang Ji, Danyuan Li, Ying Liang and Yangchao Luo

J. Mater. Chem. B, 2025, 13, 13122
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Investigation of formation of well-known AGEs precursors in cookies using an in vitro simulated gastrointestinal digestive system

Mustafa Yaman, Mehmet Demirci, Elif Ede-Cintesun, Edanur Kurt and Ömer Faruk Mızrak

Food Chemistry, 2022, 373, 131451
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Undigested glycated lentil proteins modulate the gut microbiota profile but not the metabolites in vitro

Ruth T. Boachie, Edoardo Capuano, Teresa Oliviero, Chibuike C. Udenigwe and Vincenzo Fogliano

Journal of Functional Foods, 2023, 107, 105667
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High fructose corn syrup, excess-free-fructose, and risk of coronary heart disease among African Americans– the Jackson Heart Study

Luanne R. DeChristopher, Brandon J. Auerbach and Katherine L. Tucker

BMC Nutr, 2020, 6
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Effects of fish protein with glycation extent on gut microbiota and colonic barrier function in mice fed a high-fat diet

Caocao Cao, Mingjun Tang, Nana Zhao, Shiyuan Dong and Haohao Wu

Journal of Functional Foods, 2021, 85, 104636
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Generation of advanced glycation end products from glycated protein or fructose/glyoxal-protein adducts under in vitro simulated gastrointestinal digestion

Xiaojin Yuan, Shuqing Feng, Jianuo Li, Ruixin Guo, Chenxi Nie, Ruohan Zhai, Aobai Tu, Xinyu Cao, Min Zhang and Juxiu Li

Food Chemistry, 2025, 463, 141175
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Protein-bound and free glycation compounds in human milk: A comparative study with minimally processed infant formula and pasteurized bovine milk

Simona Arena, Sabrina De Pascale, Valentina Ciaravolo, Mariela Mejia Monroy, Joost W. Gouw, Bernd Stahl, Christine Bäuerl, Maria Carmen Collado, Carlotta De Filippo, Andrea Scaloni and Antonio Dario Troise

Food Chemistry, 2025, 463, 141265
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Association of fructose consumption with prevalence of functional gastrointestinal disorders manifestations: results from Hellenic National Nutrition and Health Survey (HNNHS)

Theodoros Smiliotopoulos, Antonis Zampelas, George Houliaras, Spiros N. Sgouros, George Michas, George Bamias, Demosthenes Panagiotakos, Nikolaos Cholopoulos, George P. Chrousos, Eleftheria Roma and Emmanuella Magriplis

Br J Nutr, 2023, 130, 1961
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Maillard reaction products in plant-based dairy alternatives and their release during simulated gastrointestinal digestion

Kira Bieck, Franziska Ebert, Tilman Grune and Jana Raupbach

Current Research in Food Science, 2025, 10, 100994
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Role of glycated proteins in vivo: Enzymatic glycated proteins and non-enzymatic glycated proteins

Qian Wu, Yinggang Liang, Yingfei Kong, Fen Zhang, Yingna Feng, Yu Ouyang, Chao Wang, Zhiqiang Guo, Juan Xiao and Nianjie Feng

Food Research International, 2022, 155, 111099
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Phytochemical composition, antioxidant, antiglycation, and antihyperlipidemic activity of flowering parts from five plant species before and after in vitro digestion

Valerija Vujčić Bok, Domagoj Bosiljevac, Ivana Šola, Ana Vukres, Gordana Rusak and Željan Maleš

Acta Pharmaceutica, 2025, 75, 357
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Systematic Review: Contribution of the Gut Microbiome to the Volatile Metabolic Fingerprint of Colorectal Neoplasia

Robert van Vorstenbosch, Hao Ran Cheng, Daisy Jonkers, John Penders, Erik Schoon, Ad Masclee, Frederik-Jan van Schooten, Agnieszka Smolinska and Zlatan Mujagic

Metabolites, 2022, 13, 55
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Glycation of tilapia protein hydrolysate decreases cellular antioxidant activity upon in vitro gastrointestinal digestion

Xiaogang Zhang, Parinya Noisa, Ali Hamzeh and Jirawat Yongsawatdigul

Food Chemistry: X, 2024, 21, 101228
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A review of in-vitro digestibility models on diverse foods in various segments of human digestive tract

B. Shiva Kiran, Omar Bashir, Prashant Anil Pawase, Kshirod Kumar Dash, Tawheed Amin, Rafeeya Shams, Ayaz Mukarram Shaikh and Kovács Béla

Discov Food, 2025, 5
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Recent developments in in-vitro assessment of advanced glycation end products

Yeliz Serin, Gamze Akbulut, Halime Uğur and Mustafa Yaman

Current Opinion in Food Science, 2021, 40, 136
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Studies on the Reaction of Dietary Methylglyoxal and Creatine during Simulated Gastrointestinal Digestion and in Human Volunteers

Stephanie Treibmann, Julia Groß, Susann Pätzold and Thomas Henle

Nutrients, 2022, 14, 3598
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Dietary Advanced Glycation End products interacting with the intestinal epithelium: What do we really know?

Fleur A.C. Jansen, Vincenzo Fogliano, Josep Rubert and Tamara Hoppenbrouwers

Molecular Metabolism, 2023, 73, 101734
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Unveiling the Impact of Processing Methods on In Vitro Protein Digestibility: A Focus on Highland Barley and Its Application in Wine Production

Mengchuan He, Xinjing Zhou, András Koris, Bingyu Chen, Xuchun Zhu, Feiyue Ren and Hongzhi Liu

Foods, 2025, 14, 2020
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Comparison of metabolic fate, target organs, and microbiota interactions of free and bound dietary advanced glycation end products

Xiaojin Yuan, Chenxi Nie, Huicui Liu, Qingyu Ma, Bo Peng, Min Zhang, Zhifei Chen and Juxiu Li

Critical Reviews in Food Science and Nutrition, 2023, 63, 3612
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Research advances of advanced glycation end products in milk and dairy products: Formation, determination, control strategy and immunometabolism via gut microbiota

Lezhen Dong, Ying Li, Qin Chen, Yahui Liu, Zhaohui Qiao, Shangyuan Sang, Jingshun Zhang, Shengnan Zhan, Zufang Wu and Lianliang Liu

Food Chemistry, 2023, 417, 135861
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Effect of glycation derived from α-dicarbonyl compounds on the in vitro digestibility of ovalbumin: Tracing of advanced glycation end-products and immuno-active peptides

Zhijie Huang, Yuhao Jiang, Huatao Li, Qianqian Li, Zhongshan Gao, Yan Zhang, Qiaozhi Zhang and Linglin Fu

Food Research International, 2023, 169, 112842
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Generation and Accumulation of Various Advanced Glycation End-Products in Cardiomyocytes May Induce Cardiovascular Disease

Takanobu Takata, Shinya Inoue, Togen Masauji, Katsuhito Miyazawa and Yoshiharu Motoo

IJMS, 2024, 25, 7319
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Exceptionally versatile take II: post-translational modifications of lysine and their impact on bacterial physiology

Jürgen Lassak, Alina Sieber and Michael Hellwig

Biological Chemistry, 2022, 403, 819
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Glycation reactions of methylglyoxal during digestion in a dynamic, in vitro model of the upper gastrointestinal tract (TIM‐1)

Stephanie Treibmann, Koen Venema and Thomas Henle

Food Science & Nutrition, 2024, 12, 4702
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Glucose addition and oven-heating of pork stimulate glycoxidation and protein carbonylation, while reducing lipid oxidation during simulated gastrointestinal digestion

Xiaona Tian, Els Vossen, Stefaan De Smet and Thomas Van Hecke

Food Chemistry, 2024, 453, 139662
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Advanced Glycation End-Products (AGEs): Formation, Chemistry, Classification, Receptors, and Diseases Related to AGEs

Aleksandra Twarda-Clapa, Aleksandra Olczak, Aneta M. Białkowska and Maria Koziołkiewicz

Cells, 2022, 11, 1312
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Gut Metabolism of Sugars: Formation of Glycotoxins and Their Intestinal Absorption

Tamaeh Monteiro-Alfredo and Paulo Matafome

Diabetology, 2022, 3, 596
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Slot Blot- and Electrospray Ionization–Mass Spectrometry/Matrix-Assisted Laser Desorption/Ionization–Mass Spectrometry-Based Novel Analysis Methods for the Identification and Quantification of Advanced Glycation End-Products in the Urine

Takanobu Takata, Shinya Inoue, Kenshiro Kunii, Togen Masauji and Katsuhito Miyazawa

IJMS, 2024, 25, 9632
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AGE-Rich Bread Crust Extract Boosts Oxidative Stress Interception via Stimulation of the NRF2 Pathway

Kristin Wächter, Alexander Navarrete Santos, Anne Großkopf, Tim Baldensperger, Marcus A. Glomb, Gábor Szabó and Andreas Simm

Nutrients, 2021, 13, 3874
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Dietary Advanced Glycation End-Products and Colorectal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study

Elom K. Aglago, Ana-Lucia Mayén, Viktoria Knaze, Heinz Freisling, Veronika Fedirko, David J. Hughes, Li Jiao, Anne Kirstine Eriksen, Anne Tjønneland, Marie-Christine Boutron-Ruault, Joseph A. Rothwell, Gianluca Severi, Rudolf Kaaks, Verena Katzke, Matthias B. Schulze, Anna Birukov, Domenico Palli, Sabina Sieri, Maria Santucci de Magistris, Rosario Tumino, Fulvio Ricceri, Bas Bueno-de-Mesquita, Jeroen W. G. Derksen, Guri Skeie, Inger Torhild Gram, Torkjel Sandanger, J. Ramón Quirós, Leila Luján-Barroso, Maria-Jose Sánchez, Pilar Amiano, María-Dolores Chirlaque, Aurelio Barricarte Gurrea, Ingegerd Johansson, Jonas Manjer, Aurora Perez-Cornago, Elisabete Weiderpass, Marc J. Gunter, Alicia K. Heath, Casper G. Schalkwijk and Mazda Jenab

Nutrients, 2021, 13, 3132
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Occurrence of dietary advanced glycation end-products in commercial cow, goat and soy protein based infant formulas

Yajing Xie, H.J. van der Fels-Klerx, Stefan P.J. van Leeuwen and Vincenzo Fogliano

Food Chemistry, 2023, 411, 135424
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The inhibitory effects of endophytic metabolites on glycated proteins under non-communicable disease conditions: A review

Muhammad Nawaz, Muhammad Naveed Afridi, Irfan Ullah, Iftikhar Ali Khan, Muhammad Saqib Ishaq, Yuting Su, Hafiz Muhammad Rizwan, Ka-Wing Cheng, Qian Zhou and Mingfu Wang

International Journal of Biological Macromolecules, 2024, 269, 131869
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Effect of Protein, Carbohydrate, and Oil on Phytochemical Bioaccessibility and Bioactivities of the Ginkgo biloba L. Leaf Formulations After In Vitro Digestion

Gordana Rusak, Valerija Vujčić Bok, Ivana Šola, Ema Nikša and Željan Maleš

Molecules, 2024, 29, 5300
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Inhibition of heterocyclic aromatic amines and advanced glycation end products in cooked meat products: Emphasizing on nanotechnology

Guanhua Li, Iftikhar Hussain Badar, Xiurong Zheng, Minchen Wang, Yingying Hu and Lang Zhang

Journal of Food Composition and Analysis, 2026, 150, 108865
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Indigestible proteins and peptide-bound AGEs in ultra-processed foods: Dulce de leche as a model of severely transformed protein food systems

Gianluca Picariello, Simonetta Caira, Gabriella Pinto, Francesco Siano, Francesca Marino, Andrea Scaloni and Francesco Addeo

Food Bioscience, 2024, 62, 105327
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40 years of adding more fructose to high fructose corn syrup than is safe, through the lens of malabsorption and altered gut health–gateways to chronic disease

Luanne Robalo DeChristopher

Nutr J, 2024, 23
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Assessment of protein and phospholipid bioaccessibility in ultrafiltered buttermilk cheese using TIM-1 in vitro gastrointestinal methods

Louise Krebs, Jessica Verhoeven, Sanne Verbruggen, Aleksander Lesar, Rihab Meddah, Maude Blouin, Koen Venema, Julien Chamberland and Guillaume Brisson

Food Research International, 2024, 190, 114606
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The Intake of Dicarbonyls and Advanced Glycation Endproducts as Part of the Habitual Diet Is Not Associated with Intestinal Inflammation in Inflammatory Bowel Disease and Irritable Bowel Syndrome Patients

Marlijne C. G. de Graaf, Jean L. J. M. Scheijen, Corinne E. G. M. Spooren, Zlatan Mujagic, Marieke J. Pierik, Edith J. M. Feskens, Daniel Keszthelyi, Casper G. Schalkwijk and Daisy M. A. E. Jonkers

Nutrients, 2022, 15, 83
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Disproportionately higher cardiovascular disease risk and incidence with high fructose corn syrup sweetened beverage intake among black young adults–the CARDIA study

Luanne Robalo DeChristopher and Katherine L. Tucker

Nutr J, 2024, 23
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Wheat milling across history altered sugar bioaccessibility assessed using TIM-1 in vitro digestion model

Hala Amer, Zhitong Zhou, Maria G. Corradini, Iris J. Joye and Michael A. Rogers

Food Research International, 2023, 174, 113521
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Dietary Advanced Glycation Endproducts and the Gastrointestinal Tract

Timme van der Lugt, Antoon Opperhuizen, Aalt Bast and Misha F. Vrolijk

Nutrients, 2020, 12, 2814
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Differences in kinetics and dynamics of endogenous versus exogenous advanced glycation end products (AGEs) and their precursors

Katja C.W. van Dongen, Leonie Kappetein, Ignacio Miro Estruch, Clara Belzer, Karsten Beekmann and Ivonne M.C.M. Rietjens

Food and Chemical Toxicology, 2022, 164, 112987
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Rye Bread Crust as an Inducer of Antioxidant Genes and Suppressor of NF-κB Pathway In Vivo

Kristin Wächter, Birte Gohde, Gábor Szabó and Andreas Simm

Nutrients, 2022, 14, 4790
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Cultivating complexity: Advancements in establishing in vitro models for the mucus‐adhering gut microbiota

Marco Calvigioni, Diletta Mazzantini, Francesco Celandroni, Giovanni Vozzi and Emilia Ghelardi

Microbial Biotechnology, 2024, 17
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Disproportionately higher asthma risk and incidence with high fructose corn syrup, but not sucrose intake, among Black young adults: the CARDIA Study

Luanne Robalo DeChristopher and Katherine L Tucker

Public Health Nutr., 2025, 28
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Balancing the dual nature of glycotoxins: interplay of diet, digestion, and gut microbiome

Halyna Semchyshyn

Front. Nutr., 2025, 12
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Dairy Foods: A Matrix for Human Health and Precision Nutrition—Effect of processing infant milk formula on protein digestion and gut barrier health (in vitro and preclinical)

Cathal A. Dold, Aylin W. Sahin and Linda Giblin

Journal of Dairy Science, 2025, 108, 3088
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