EuroTracker dyes: highly emissive europium complexes as alternative organelle stains for live cell imaging

Stephen J. Butler, Laurent Lamarque, Robert Pal and David Parker

Chem. Sci., 2014, 5, 1750
DOI: 10.1039/c3sc53056f

Dinuclear ruthenium(ii) antimicrobial agents that selectively target polysomes in vivo

Fangfei Li, Elizabeth J. Harry, Amy L. Bottomley, Michael D. Edstein, Geoffrey W. Birrell, Clifford E. Woodward, F. Richard Keene and J. Grant Collins

Chem. Sci., 2014, 5, 685
DOI: 10.1039/C3SC52166D

Stability, accumulation and cytotoxicity of an albumin-cisplatin adduct

Charlotte Møller, Hanne Sørup Tastesen, Bente Gammelgaard, Ian Henry Lambert and Stefan Stürup

Metallomics, 2010, 2, 811
DOI: 10.1039/c0mt00046a

Modulation of the organelle specificity in Re(i) tetrazolato complexes leads to labeling of lipid droplets

Christie A. Bader, Robert D. Brooks, Yeap S. Ng, Alexandra Sorvina, Melissa V. Werrett, Phillip J. Wright, Ayad G. Anwer, Douglas A. Brooks, Stefano Stagni, Sara Muzzioli, Morry Silberstein, Brian W. Skelton, Ewa M. Goldys, Sally E. Plush, Tetyana Shandala and Massimiliano Massi

RSC Adv., 2014, 4, 16345
DOI: 10.1039/C4RA00050A

Pushing the limit: synthesis, photophysical and DNA binding studies of a NIR-emitting Ru(ii)-polypyridyl probe with ‘light switch’ behaviour

Robert B. P. Elmes, Jonathan A. Kitchen, D. Clive Williams and Thorfinnur Gunnlaugsson

Dalton Trans., 2012, 41, 6607
DOI: 10.1039/c2dt00020b

Enhanced cellular uptake and photochemotherapeutic potential of a lipophilic strained Ru(ii) polypyridyl complex

Stephanie Mehanna, Najwa Mansour, Hassib Audi, Kikki Bodman-Smith, Mohamad A. Mroueh, Robin I. Taleb, Costantine F. Daher and Rony S. Khnayzer

RSC Adv., 2019, 9, 17254
DOI: 10.1039/C9RA02615K

A turn-on fluorogenic Zn(ii) chemoprobe based on a terpyridine derivative with aggregation-induced emission (AIE) effects through nanofiber aggregation into spherical aggregates

Sung Ho Jung, Ki-Young Kwon and Jong Hwa Jung

Chem. Commun., 2015, 51, 952
DOI: 10.1039/C4CC05283H

DNA and BSA binding and cytotoxic properties of copper(ii) and iron(iii) complexes with arylhydrazone of ethyl 2-cyanoacetate or formazan ligands

Nuno M. R. Martins, Sellamuthu Anbu, Kamran T. Mahmudov, Rajendran Ravishankaran, M. Fátima C. Guedes da Silva, Luísa M. D. R. S. Martins, Anjali A. Karande and Armando J. L. Pombeiro

New J. Chem., 2017, 41, 4076
DOI: 10.1039/C7NJ00420F

A molecular light switch Ru complex and quantum dots for the label-free, aptamer-based detection of thrombin

Wenliang Sun, Tianming Yao and Shuo Shi

Analyst, 2012, 137, 1550
DOI: 10.1039/c2an16181h

Lanthanide-based tools for the investigation of cellular environments

Emilie Mathieu, Agnès Sipos, Ellen Demeyere, Dulcie Phipps, Dimitra Sakaveli and K. Eszter Borbas

Chem. Commun., 2018, 54, 10021
DOI: 10.1039/C8CC05271A

RNA and DNA binding of inert oligonuclear ruthenium(ii) complexes in live eukaryotic cells

Xin Li, Anil K. Gorle, Tracy D. Ainsworth, Kirsten Heimann, Clifford E. Woodward, J. Grant Collins and F. Richard Keene

Dalton Trans., 2015, 44, 3594
DOI: 10.1039/C4DT02575J

New imaging reagents for lipid dense regions in live cells and the nucleus in fixed MCF-7 cells

Vadde Ramu, Firoj Ali, Nandaraj Taye, Bikash Garai, Aftab Alam, Samit Chattopadhyay and Amitava Das

J. Mater. Chem. B, 2015, 3, 7177
DOI: 10.1039/C5TB01309G

A monoadduct generating Ru(ii) complex induces ribosome biogenesis stress and is a molecular mimic of phenanthriplatin

Richard J. Mitchell, Sarah M. Kriger, Alexander D. Fenton, Dmytro Havrylyuk, Ankit Pandeya, Yang Sun, Tami Smith, Jason E. DeRouchey, Jason M. Unrine, Viral Oza, Jessica S. Blackburn, Yinan Wei, David K. Heidary and Edith C. Glazer

RSC Chem. Biol., 2023, 4, 344
DOI: 10.1039/D2CB00247G

Asymmetric rhenium tricarbonyl complexes show superior luminescence properties in live cell imaging

Lukasz J. Raszeja, Daniel Siegmund, Anna L. Cordes, Jörn Güldenhaupt, Klaus Gerwert, Stephan Hahn and Nils Metzler-Nolte

Chem. Commun., 2017, 53, 905
DOI: 10.1039/C6CC07553C

New encapsulated bis-cyclometalated Ir(iii) complexes with very potent anticancer PDT activity

Cristina Bermejo-Casadesús, Carlos Gonzalo-Navarro, Juan Angel Organero, Ana María Rodríguez, Lucía Santos, Elisenda Zafon, Joao Carlos Lima, Artur J. Moro, Mònica Iglesias, Pedro Tavares, Daniel Martínez, Blanca R. Manzano, Anna Massaguer and Gema Durá

Inorg. Chem. Front., 2025, 12, 7304
DOI: 10.1039/D5QI00775E

Tri- and tetranuclear RuII–GdIII2 and RuII–GdIII3 d–f heterometallic complexes as potential bimodal imaging probes for MRI and optical imaging

A. Nithyakumar and V. Alexander

New J. Chem., 2016, 40, 4606
DOI: 10.1039/C5NJ03393D

Disruption of microtubule function in cultured human cells by a cytotoxic ruthenium(ii) polypyridyl complex

Nagham Alatrash, Faiza H. Issa, Nada S. Bawazir, Savannah J. West, Kathleen E. Van Manen-Brush, Charles P. Shelor, Adam S. Dayoub, Kenneth A. Myers, Christopher Janetopoulos, Edwin A. Lewis and Frederick M. MacDonnell

Chem. Sci., 2020, 11, 264
DOI: 10.1039/C9SC05671H

Synthesis, structures, cellular uptake and apoptosis-inducing properties of highly cytotoxic ruthenium-Norharman complexes

Caiping Tan, Shouhai Wu, Sensen Lai, Minxu Wang, Yu Chen, Lingjun Zhou, Yiping Zhu, Wu Lian, Wenlie Peng, Liangnian Ji and Anlong Xu

Dalton Trans., 2011, 40, 8611
DOI: 10.1039/c1dt10084j

Rhenium tricarbonyl complexes of AIE active tetraarylethylene ligands: tuning luminescence properties and HSA-specific binding

Moustafa T. Gabr and F. Christopher Pigge

Dalton Trans., 2017, 46, 15040
DOI: 10.1039/C7DT03380J

The path for metal complexes to a DNA target

Alexis C. Komor and Jacqueline K. Barton

Chem. Commun., 2013, 49, 3617
DOI: 10.1039/c3cc00177f

Mechanism of cellular accumulation of an iridium(iii) pentamethylcyclopentadienyl anticancer complex containing a C,N-chelating ligand

Vojtech Novohradsky, Zhe Liu, Marie Vojtiskova, Peter J. Sadler, Viktor Brabec and Jana Kasparkova

Metallomics, 2014, 6, 682
DOI: 10.1039/C3MT00341H

Chiral heterobimetallic complexes targeting human DNA-topoisomerase Iα

Sartaj Tabassum, Ahmad Asim, Rais Ahmad Khan, Zahid Hussain, Saurabh Srivastav, Saripella Srikrishna and Farukh Arjmand

Dalton Trans., 2013, 42, 16749
DOI: 10.1039/c3dt51209f

Recent development of luminescent rhenium(i) tricarbonyl polypyridine complexes as cellular imaging reagents, anticancer drugs, and antibacterial agents

Lawrence Cho-Cheung Lee, Kam-Keung Leung and Kenneth Kam-Wing Lo

Dalton Trans., 2017, 46, 16357
DOI: 10.1039/C7DT03465B

Synthesis and anticancer activity of carbosilane metallodendrimers based on arene ruthenium(ii) complexes

Marta Maroto-Díaz, Benelita T. Elie, Pilar Gómez-Sal, Jorge Pérez-Serrano, Rafael Gómez, María Contel and F. Javier de la Mata

Dalton Trans., 2016, 45, 7049
DOI: 10.1039/C6DT00465B

Long-lived metal complexes open up microsecond lifetime imaging microscopy under multiphoton excitation: from FLIM to PLIM and beyond

Elizabeth Baggaley, Stanley W. Botchway, John W. Haycock, Hayley Morris, Igor V. Sazanovich, J. A. Gareth Williams and Julia A. Weinstein

Chem. Sci., 2014, 5, 879
DOI: 10.1039/C3SC51875B

Synthesis, characterization and biological activity of bromido[3-ethyl-4-aryl-5-(2-methoxypyridin-5-yl)-1-propyl-1,3-dihydro-2H-imidazol-2-ylidene]gold(i) complexes

Caroline M. Gallati, Sina K. Goetzfried, Marjana Ausserer, Jessica Sagasser, Matthias Plangger, Klaus Wurst, Martin Hermann, Daniel Baecker, Brigitte Kircher and Ronald Gust

Dalton Trans., 2020, 49, 5471
DOI: 10.1039/C9DT04824C

Synthesis, characterization and biological evaluation of mixed-ligand ruthenium(ii) complexes for photodynamic therapy

Huaiyi Huang, Pingyu Zhang, Bole Yu, Chengzhi Jin, Liangnian Ji and Hui Chao

Dalton Trans., 2015, 44, 17335
DOI: 10.1039/C5DT02081F

Photophysical and biological investigation of novel luminescent Ru(ii)-polypyridyl-1,8-naphthalimide Tröger's bases as cellular imaging agents

Robert B. P. Elmes, Marialuisa Erby, Sandra A. Bright, D. Clive Williams and Thorfinnur Gunnlaugsson

Chem. Commun., 2012, 48, 2588
DOI: 10.1039/c2cc17274g

Studies of ruthenium(ii)-2,2′-bisimidazole complexes on binding to G-quadruplex DNA and inducing apoptosis in HeLa cells

Yu Xia, Qingchang Chen, Xiuying Qin, Dongdong Sun, Jingnan Zhang and Jie Liu

New J. Chem., 2013, 37, 3706
DOI: 10.1039/c3nj00542a

The biological effect of the nitroimidazole derivative of a polypyridyl ruthenium complex on cancer and endothelial cells

Olga Mazuryk, Franck Suzenet, Claudine Kieda and Małgorzata Brindell

Metallomics, 2015, 7, 553
DOI: 10.1039/C5MT00037H

Antiproliferative activity of chelating N,O- and N,N-ruthenium(ii) arene functionalised poly(propyleneimine) dendrimer scaffolds

Preshendren Govender, Anna K. Renfrew, Catherine M. Clavel, Paul J. Dyson, Bruno Therrien and Gregory S. Smith

Dalton Trans., 2011, 40, 1158
DOI: 10.1039/C0DT00761G

Applications of luminescent inorganic and organometallic transition metal complexes as biomolecular and cellular probes

Kenneth Kam-Wing Lo, Alex Wing-Tat Choi and Wendell Ho-Tin Law

Dalton Trans., 2012, 41, 6021
DOI: 10.1039/c2dt11892k

Potent and selective in vitro and in vivo antiproliferative effects of metal–organic trefoil knots

Farah Benyettou, Thirumurugan Prakasam, Anjana Ramdas Nair, Ini-Isabee Witzel, Marwa Alhashimi, Tina Skorjanc, John-Carl Olsen, Kirsten C. Sadler and Ali Trabolsi

Chem. Sci., 2019, 10, 5884
DOI: 10.1039/C9SC01218D

New avenues in the design and potential application of metal complexes for photodynamic therapy

Oliver J. Stacey and Simon J. A. Pope

RSC Adv., 2013, 3, 25550
DOI: 10.1039/c3ra45219k

Mitochondrial and nuclear DNA dual damage induced by 2-(2′-quinolyl)benzimidazole copper complexes with potential anticancer activity

Jin'an Zhao, Shuangcheng Zhi, Huaibin Yu, Ruina Mao, Jiyong Hu, Wei Song and Junshuai Zhang

RSC Adv., 2017, 7, 51162
DOI: 10.1039/C7RA09102H

Photodynamic therapy with mitochondria-targeted biscyclometallated Ir(iii) complexes. Multi-action mechanism and strong influence of the cyclometallating ligand

Elisenda Zafon, Igor Echevarría, Sílvia Barrabés, Blanca R. Manzano, Félix A. Jalón, Ana M. Rodríguez, Anna Massaguer and Gustavo Espino

Dalton Trans., 2022, 51, 111
DOI: 10.1039/D1DT03080A

Ruthenium complexes as antimicrobial agents

Fangfei Li, J. Grant Collins and F. Richard Keene

Chem. Soc. Rev., 2015, 44, 2529
DOI: 10.1039/C4CS00343H

Utilization of the photophysical and photochemical properties of phosphorescent transition metal complexes in the development of photofunctional cellular sensors, imaging reagents, and cytotoxic agents

Kenneth Kam-Wing Lo and Steve Po-Yam Li

RSC Adv., 2014, 4, 10560
DOI: 10.1039/c3ra47611a

Quantitative determination and subcellular mapping of Pt-based drugs in single breast tumour cells via laser ablation-ICP-mass spectrometry

Legna Colina-Vegas, Thibaut Van Acker, Wilmer Villarreal, Olivier De Wever, Alzir Azevedo Batista, Joaquim Araújo Nóbrega and Frank Vanhaecke

Dalton Trans., 2024, 53, 18880
DOI: 10.1039/D4DT02467B

Inorganic pharmaceuticals

Alvin A. Holder

Annu. Rep. Prog. Chem., Sect. A: Inorg. Chem., 2011, 107, 359
DOI: 10.1039/c1ic90005f

Controlled intra- and extracellular localization of bioorthogonal polymeric nanozymes

Cristina-Maria Hirschbiegel, Mathangi Shrikanth, Yagiz Anil Cicek, Nourina Nasim, Joe Truong, Junwhee Yang, Alexander Ribbe, Maged Abdelaziz and Vincent M. Rotello

Chem. Sci., 2026, 17, 4050
DOI: 10.1039/D5SC07223A

Unravelling the correlation between metal induced aggregation and cellular uptake/subcellular localization of Znsalen: an overlooked rule for design of luminescent metal probes

Juan Tang, Yuan-Bo Cai, Jing Jing and Jun-Long Zhang

Chem. Sci., 2015, 6, 2389
DOI: 10.1039/C4SC03824J

Strategies to promote permeation and vectorization, and reduce cytotoxicity of metal complex luminophores for bioimaging and intracellular sensing

Lorcan Holden, Christopher S. Burke, David Cullinane and Tia E. Keyes

RSC Chem. Biol., 2021, 2, 1021
DOI: 10.1039/D1CB00049G

The development of anticancer ruthenium(ii) complexes: from single molecule compounds to nanomaterials

Leli Zeng, Pranav Gupta, Yanglu Chen, Enju Wang, Liangnian Ji, Hui Chao and Zhe-Sheng Chen

Chem. Soc. Rev., 2017, 46, 5771
DOI: 10.1039/C7CS00195A

Disruption of lipid metabolism to induce ferroptosis using multifunctional fibrate-Pt(iv) prodrugs for cancer treatment

Peng Sun, Jia-Qian Wang, Qiang Xie, Xuan-Lin Ren, Xin Qiao and Jing-Yuan Xu

Inorg. Chem. Front., 2024, 11, 2914
DOI: 10.1039/D4QI00386A

The status of platinum anticancer drugs in the clinic and in clinical trials

Nial J. Wheate, Shonagh Walker, Gemma E. Craig and Rabbab Oun

Dalton Trans., 2010, 39, 8113
DOI: 10.1039/c0dt00292e

Progress with, and prospects for, metal complexes in cell imaging

Michael P. Coogan and Vanesa Fernández-Moreira

Chem. Commun., 2014, 50, 384
DOI: 10.1039/C3CC45229H

Mixed-ligand ruthenium polypyridyl complexes as apoptosis inducers in cancer cells, the cellular translocation and the important role of ROS-mediated signaling

Zhennan Zhao, Zuandi Luo, Qiong Wu, Wenjie Zheng, Yanxian Feng and Tianfeng Chen

Dalton Trans., 2014, 43, 17017
DOI: 10.1039/C4DT01392A

An efficient route to asymmetrically diconjugated tris(heteroleptic) complexes of Ru(ii)

Christopher S. Burke and Tia E. Keyes

RSC Adv., 2016, 6, 40869
DOI: 10.1039/C6RA06086B

Synthesis, characterisation and bioimaging of a fluorescent rhenium-containing PNA bioconjugate

Gilles Gasser, Antonio Pinto, Sebastian Neumann, Anna M. Sosniak, Michael Seitz, Klaus Merz, Rolf Heumann and Nils Metzler-Nolte

Dalton Trans., 2012, 41, 2304
DOI: 10.1039/C2DT12114J

MRI and fluorescence studies of Saccharomyces cerevisiae loaded with a bimodal Fe(III) T1 contrast agent

Akanksha Patel, Didar Asik, Joseph A. Spernyak, Paul J. Cullen and Janet R. Morrow

Journal of Inorganic Biochemistry, 2019, 201, 110832
DOI: 10.1016/j.jinorgbio.2019.110832

Simple but powerful: Phenanthroline-based small molecules for cellular imaging and cancer screening

Natalia N. Sergeeva, Marion Donnier-Marechal, Gisela M. Vaz, Anthony M. Davies and Mathias O. Senge

Bioorganic & Medicinal Chemistry Letters, 2011, 21, 4385
DOI: 10.1016/j.bmcl.2011.06.051

Visualizing the Invisible: Dual Click Imaging of Ruthenium-Based Photoactivated Chemotherapy Agents and Their DNA Synthesis Inhibition in Fixed Cancer Cells

Anja Busemann, Lisa Rieger, Rachael M. Cunningham, Sam C. Davidse, Irene Regeni, Ingrid Flaspohler, Claudia Schmidt, Xue-Quan Zhou, Vincent van Rixel, Maxime A. Siegler, Ingo Ott, Sylvia E. Le Dévédec, Hans-Achim Wagenknecht, Victoria J. DeRose and Sylvestre Bonnet

J. Am. Chem. Soc., 2025
DOI: 10.1021/jacs.5c13249

Mechanism of Cytotoxicity and Cellular Uptake of Lipophilic Inert Dinuclear Polypyridylruthenium(II) Complexes

Michelle J. Pisani, Phillip D. Fromm, Yanyan Mulyana, Ronald J. Clarke, Heinrich Körner, Kirsten Heimann, J. Grant Collins and F. Richard Keene

ChemMedChem, 2011, 6, 848
DOI: 10.1002/cmdc.201100053

Metal Complex Mediated Conjugation of Peptides to Nucleus Targeting Acridine Orange: A Modular Concept for Dual-Modality Imaging Agents

Karel Zelenka, Lubor Borsig and Roger Alberto

Bioconjugate Chem., 2011, 22, 958
DOI: 10.1021/bc2000269

Molecular Design of Bioorthogonal Probes and Imaging Reagents Derived from Photofunctional Transition Metal Complexes

Kenneth Kam-Wing Lo

Acc. Chem. Res., 2020, 53, 32
DOI: 10.1021/acs.accounts.9b00416

Polypyridyl Metal Complexes with Biological Activity

Luca Salassa

Eur J Inorg Chem, 2011, 2011, 4931
DOI: 10.1002/ejic.201100376

Towards Artificial Metallonucleases for Gene Therapy: Recent Advances and New Perspectives

Béla Gyurcsik and Anikó Czene

Future Med. Chem., 2011, 3, 1935
DOI: 10.4155/fmc.11.139

Light-Activated Metal-Dependent Protein Degradation: A Heterobifunctional Ruthenium(II) Photosensitizer Targeting New Delhi Metallo-β-lactamase 1

Lars Stevens-Cullinane, Thomas W. Rees, Calum Evans, Po-Yu Ho, Mika Kintzel, Yew Mun Yip, Ruoning Jia, Jonathan Bailey, Eleanor Clifford, Ruqaiya Alam, Sarah Maslen, Stephane Mouilleron, Adrien Pasquier, Ok-Ryul Song, Scott Warchal, Joanna Redmond, Michael Howell, Svend Kjær, Mark Skehel, Manuel M. Müller, Eachan O. Johnson, Maxie M. Roessler and Jeannine Hess

J. Am. Chem. Soc., 2025, 147, 44860
DOI: 10.1021/jacs.5c12405

Photodynamic therapy applications of Re(I)‐BODIPY functionalized nanoparticles

Nidhi Tyagi, Navneet Kaur, Subash Chandra Sahoo and Paloth Venugopalan

Applied Organom Chemis, 2022, 36
DOI: 10.1002/aoc.6494

A Cytostatic Ruthenium(II)–Platinum(II) Bis(terpyridyl) Anticancer Complex That Blocks Entry into S Phase by Up‐regulating p27KIP1

Vadde Ramu, Martin R. Gill, Paul J. Jarman, David Turton, Jim A. Thomas, Amitava Das and Carl Smythe

Chemistry A European J, 2015, 21, 9185
DOI: 10.1002/chem.201500561

Synthesis, spectral properties, DNA binding interactions and DNA cleavage studies of lanthanide (III) complexes of 2-acetylpyridine acetoylhydrazone: the X-ray crystal structure of 10-coordinate Ce (III) and Sm (III) complexes

Karreddula Raja, Akkili Suseelamma and Katreddi Hussain Reddy

J IRAN CHEM SOC, 2015, 12, 1473
DOI: 10.1007/s13738-015-0624-x

Evaluation of Efficiency of Liposome-Entrapped Iridium(III) Complexes Inhibiting Tumor Growth In Vitro and In Vivo

Huiyan Hu, Jing Chen, Fan Zhang, Zhujun Sheng, Yan Yang, Yufeng Xie, Lin Zhou and Yunjun Liu

J. Med. Chem., 2024, 67, 16195
DOI: 10.1021/acs.jmedchem.4c01026

Enhanced Cytotoxicity through Conjugation of a “Clickable” Luminescent Re(I) Complex to a Cell-Penetrating Lipopeptide

Anna Leonidova, Vanessa Pierroz, Luke A. Adams, Nicholas Barlow, Stefano Ferrari, Bim Graham and Gilles Gasser

ACS Med. Chem. Lett., 2014, 5, 809
DOI: 10.1021/ml500158w

GSH Induced Controlled Release of Levofloxacin from a Purpose-Built Prodrug: Luminescence Response for Probing the Drug Release inEscherichia coliandStaphylococcus aureus

Suman Pal, Vadde Ramu, Nandaraj Taye, Devraj G. Mogare, Amar M. Yeware, Dhiman Sarkar, D. Srinivasa Reddy, Samit Chattopadhyay and Amitava Das

Bioconjugate Chem., 2016, 27, 2062
DOI: 10.1021/acs.bioconjchem.6b00324

A comparative study on in vitro cytotoxicity, cellular uptake, localization and apoptosis-inducing mechanism of two ruthenium(II) complexes

Jincan Chen, Yao Zhang, Baojun Li, Guodong Li, Xinming Jie, Ying Cui, Zhilin Zou, Xiaofeng Huang, Jiaoyue Qu and Lanmei Chen

Transit Met Chem, 2018, 43, 149
DOI: 10.1007/s11243-018-0203-y

Precise Labeling and Tracking of Lipid Droplets in Adipocytes Using a Luminescent ZnSalen Complex

Juan Tang, Yanfei Zhang, Hao‐Yan Yin, Guoheng Xu and Jun‐Long Zhang

Chemistry An Asian Journal, 2017, 12, 2533
DOI: 10.1002/asia.201701010

Endoplasmic Reticulum-Targeting Iridium(III) Complexes Induce Pyroptosis and Enhance Immunogenic Cell Death in MDA-MB-231 Cells

Wei Wu, Jiaen Huang, Yuling Li, Jiaxi Chen, Xiaowei Kuang, Manzhen Ye, Rui Chen, Junli An, Zunnan Huang and Jing Sun

J. Med. Chem., 2025, 68, 14727
DOI: 10.1021/acs.jmedchem.5c00883

Molecular and Cellular Characterization of the Biological Effects of Ruthenium(II) Complexes Incorporating 2-Pyridyl-2-pyrimidine-4-carboxylic Acid

Vanessa Pierroz, Tanmaya Joshi, Anna Leonidova, Cristina Mari, Julia Schur, Ingo Ott, Leone Spiccia, Stefano Ferrari and Gilles Gasser

J. Am. Chem. Soc., 2012, 134, 20376
DOI: 10.1021/ja307288s

Biological activity and cellular uptake of [Ru(η5-C5H5)(PPh3)(Me2bpy)][CF3SO3] complex

Tânia S. Morais, Filipa Santos, Leonor Côrte-Real, Fernanda Marques, M. Paula Robalo, Paulo J. Amorim Madeira and M. Helena Garcia

Journal of Inorganic Biochemistry, 2013, 122, 8
DOI: 10.1016/j.jinorgbio.2013.01.011

Mechanisms Controlling the Cellular Accumulation of Copper Bis(thiosemicarbazonato) Complexes

Katherine Ann Price, Peter J. Crouch, Irene Volitakis, Brett M. Paterson, SinChun Lim, Paul S. Donnelly and Anthony R. White

Inorg. Chem., 2011, 50, 9594
DOI: 10.1021/ic201334q

Electrochemiluminescent Monomers for Solid Support Syntheses of Ru(II)-PNA Bioconjugates: Multimodal Biosensing Tools with Enhanced Duplex Stability

Tanmaya Joshi, Gregory J. Barbante, Paul S. Francis, Conor F. Hogan, Alan M. Bond, Gilles Gasser and Leone Spiccia

Inorg. Chem., 2012, 51, 3302
DOI: 10.1021/ic202761w

Green Synthesis, Characterization, Antimicrobial and Anticancer Screening of New Metal Complexes Incorporating Schiff Base

Ali M. Hassan, Ahmed O. Said, Bassem H. Heakal, Ahmed Younis, Wael M. Aboulthana and Mohamed F. Mady

ACS Omega, 2022, 7, 32418
DOI: 10.1021/acsomega.2c03911

Structurally Strained Half-Sandwich Iridium(III) Complexes As Highly Potent Anticancer Agents

Ana C. Carrasco, Vanessa Rodríguez-Fanjul, Abraha Habtemariam and Ana M. Pizarro

J. Med. Chem., 2020, 63, 4005
DOI: 10.1021/acs.jmedchem.9b02000

Probing Amyloid Nanostructures Using Photoluminescent Metal Complexes

Bo Jiang and Angel A. Martí

Eur J Inorg Chem, 2021, 2021, 4408
DOI: 10.1002/ejic.202100422

Synthesis, characterization, DNA binding, topoisomerase inhibition, and apoptosis induction studies of a novel cobalt(III) complex with a thiosemicarbazone ligand

Stephen J. Beebe, Michael J. Celestine, Jimmie L. Bullock, Shayna Sandhaus, Jessa Faye Arca, Donald M. Cropek, Tekettay A. Ludvig, Sydney R. Foster, Jasmine S. Clark, Floyd A. Beckford, Criszcele M. Tano, Elizabeth A. Tonsel-White, Raj K. Gurung, Courtney E. Stankavich, Yuk-Ching Tse-Dinh, William L. Jarrett and Alvin A. Holder

Journal of Inorganic Biochemistry, 2020, 203, 110907
DOI: 10.1016/j.jinorgbio.2019.110907

The antimicrobial efficacy and DNA binding activity of some copper(II) complexes of 3,4,7,8-tetramethyl-1,10-phenanthroline, 4,7-diphenyl-1,10-phenanthroline and 1,2-diaminocyclohexane

Neville S. Ng, Ming J. Wu, Christopher E. Jones and Janice R. Aldrich-Wright

Journal of Inorganic Biochemistry, 2016, 162, 62
DOI: 10.1016/j.jinorgbio.2016.06.006

DNA binding, photocleavage, antimicrobial and cytotoxic properties of Ru(II) polypyridyl complexes containing BOPIP ligand, (BOPIP = {2-(4-(benzyloxy) phenyl)-1H-imidazo [4,5-f] [1,2]phenanthroline})

Srinivas Gopu, Vuradi Ravi kumar, Kotha Laxma Reddy, Putta Venkat Reddy and Satyanarayana Sirasani

Nucleosides, Nucleotides & Nucleic Acids, 2019, 38, 349
DOI: 10.1080/15257770.2018.1549329

Assessment of marine macroalgae potential for gadolinium removal from contaminated aquatic systems

Nicole Ferreira, Adriana Ferreira, Thainara Viana, Cláudia B. Lopes, Marcelo Costa, João Pinto, José Soares, José Pinheiro-Torres, Bruno Henriques and Eduarda Pereira

Science of The Total Environment, 2020, 749, 141488
DOI: 10.1016/j.scitotenv.2020.141488

Ruthenium(II)‐Dithiocarbazates as Anticancer Agents: Synthesis, Solution Behavior, and Mitochondria‐Targeted Apoptotic Cell Death

Gurunath Sahu, Sushree Aradhana Patra, Sudhir Lima, Sanchita Das, Helmar Görls, Winfried Plass and Rupam Dinda

Chemistry A European J, 2023, 29
DOI: 10.1002/chem.202202694

Lysosome-targeted ruthenium(II) complexes induce both apoptosis and autophagy in HeLa cells

Nan-Lian Pan, Jia-Xin Liao, Min-Ying Huang, Yu-Qing Zhang, Jia-Xi Chen, Ze-Wei Zhang, Zhi-Xin Yang, Xiong-En Long, Xing-Tao Wu and Jing Sun

Journal of Inorganic Biochemistry, 2022, 229, 111729
DOI: 10.1016/j.jinorgbio.2022.111729

Synthesis, Characterisation, and Preliminary In Vitro Studies of Vanadium(IV) Complexes with a Schiff Base and Thiosemicarbazones as Mixed Ligands

Nerissa A. Lewis, Fange Liu, Luke Seymour, Anthony Magnusen, Travis R. Erves, Jessa Faye Arca, Floyd A. Beckford, Ramaiyer Venkatraman, Antonio González‐Sarrías, Frank R. Fronczek, Don G. VanDerveer, Navindra P. Seeram, Aimin Liu, William L. Jarrett and Alvin A. Holder

Eur J Inorg Chem, 2012, 2012, 664
DOI: 10.1002/ejic.201100898

Rational Design of Ruthenium Complexes Containing 2,6‐Bis(benzimidazolyl)pyridine Derivatives with Radiosensitization Activity by Enhancing p53 Activation

Zhiqin Deng, Lianling Yu, Wenqiang Cao, Wenjie Zheng and Tianfeng Chen

ChemMedChem, 2015, 10, 991
DOI: 10.1002/cmdc.201500127

The Antimicrobial Activity of Mononuclear Ruthenium(II) Complexes Containing the dppz Ligand

Xuewen Liu, Biyun Sun, Ruby E. M. Kell, Hannah M. Southam, Jonathan A. Butler, Xin Li, Robert K. Poole, F. Richard Keene and J. Grant Collins

ChemPlusChem, 2018, 83, 643
DOI: 10.1002/cplu.201800042

Bioaktive lumineszierende Übergangsmetallkomplexe für biomedizinische Anwendungen

Dik‐Lung Ma, Hong‐Zhang He, Ka‐Ho Leung, Daniel Shiu‐Hin Chan and Chung‐Hang Leung

Angewandte Chemie, 2013, 125, 7820
DOI: 10.1002/ange.201208414

New Organoruthenium(II) Complexes Containing Andrographolide‐Appended Hydrazide Derivatives: Synthesis, Spectral Characterization, Anticancer Evaluation

P. Dhivakar, G. Kalaiarasi, S. Parveen, Nouf M. Alyami, Fatimah S. Alkhattaf and Priya Prasad

Applied Organom Chemis, 2025, 39
DOI: 10.1002/aoc.7777

Synthesis, Characterization, and Biological Evaluation of Red-Absorbing Fe(II) Polypyridine Complexes

Johannes Karges, Philippe Goldner and Gilles Gasser

Inorganics, 2019, 7, 4
DOI: 10.3390/inorganics7010004

Synthesis, biological activities studies of ruthenium(II) polypyridyl complexes

Bing Tang, Bing-Jie Han, Dan Wan, Shang-Hai Lai, Xiu-Zhen Wang, Cheng Zhang, Chuan-Chuan Zeng and Yun-Jun Liu

Transit Met Chem, 2017, 42, 373
DOI: 10.1007/s11243-016-0106-8

A Potential Bone-Targeting Hypotoxic Platinum(II) Complex with an Unusual Cytostatic Mechanism toward Osteosarcoma Cells

Zhenqin Zhang, Zhenzhu Zhu, Cheng Luo, Chengcheng Zhu, Changli Zhang, Zijian Guo and Xiaoyong Wang

Inorg. Chem., 2018, 57, 3315
DOI: 10.1021/acs.inorgchem.7b03261

Unlocking the Potential of Ru(II) Dual‐action Compounds with the Power of the Heavy‐atom Effect†

Nicholas P. Toupin, Sean J. Steinke, Mackenzie K Herroon, Izabela Podgorski, Claudia Turro and Jeremy J. Kodanko

Photochem & Photobiology, 2022, 98, 378
DOI: 10.1111/php.13573

Synthesis, Chemical Characterization, and Biological Evaluation of Hydrophilic Gold(I) and Silver(I) N-Heterocyclic Carbenes as Potential Anticancer Agents

Valentina Ceccherini, Ester Giorgi, Michele Mannelli, Damiano Cirri, Tania Gamberi, Chiara Gabbiani and Alessandro Pratesi

Inorg. Chem., 2024, 63, 16949
DOI: 10.1021/acs.inorgchem.4c02581

Kinetically-inert polypyridylruthenium(II) complexes as therapeutic agents

Xin Li, Anil K. Gorle, Madhu K. Sundaraneedi, F. Richard Keene and J. Grant Collins

Coordination Chemistry Reviews, 2018, 375, 134
DOI: 10.1016/j.ccr.2017.11.011

Ir(III) Half-Sandwich Photosensitizers with a π-Expansive Ligand for Efficient Anticancer Photodynamic Therapy

Carlos Gonzalo-Navarro, Elisenda Zafon, Juan Angel Organero, Félix A. Jalón, Joao Carlos Lima, Gustavo Espino, Ana María Rodríguez, Lucía Santos, Artur J. Moro, Sílvia Barrabés, Jessica Castro, Javier Camacho-Aguayo, Anna Massaguer, Blanca R. Manzano and Gema Durá

J. Med. Chem., 2024, 67, 1783
DOI: 10.1021/acs.jmedchem.3c01276

Label-free fluorescent DNA biosensors based on metallointercalators and nanomaterials

Shuo Shi, Xin Wang, Wenliang Sun, Xiangyang Wang, Tianming Yao and Liangnian Ji

Methods, 2013, 64, 305
DOI: 10.1016/j.ymeth.2013.07.004

Dual-Action Ru(II) Complexes with Bulky π-Expansive Ligands: Phototoxicity without DNA Intercalation

Nicholas P. Toupin, Sandeep Nadella, Sean J. Steinke, Claudia Turro and Jeremy J. Kodanko

Inorg. Chem., 2020, 59, 3919
DOI: 10.1021/acs.inorgchem.9b03585

Synthesis of Manganese(II), Iron(III), and Vanadium(IV) Complexes with New Schiff Bases and their Spectroscopic and Thermal Studies and Evaluation of their Antimicrobial Activity

Sinan Al-bayati, Sarab Alazawi, Sadeem Al-barody, Anaam Majeed and Rehab Alhassani

Journal of the Turkish Chemical Society Section A: Chemistry, 2024, 11, 101
DOI: 10.18596/jotcsa.1250844

A Cyclometalated Iridium(III) Complex Exerts High Anticancer Efficacy via Fatty Acid Beta-Oxidation Inhibition and Sphingolipid Metabolism Reprogramming

Cuiyan Lin, Huiling Wang, Keyu Chen, Shuangqiang Liu, Zhichen Mao, Zuyu Mo, Rizhen Huang, Ye Zhang, Wei Xie, Jianhua Wei and Junfei Jin

J. Med. Chem., 2024, 67, 14912
DOI: 10.1021/acs.jmedchem.4c00280

Solid-Phase Synthesis as a Platform for the Discovery of New Ruthenium Complexes for Efficient Release of Photocaged Ligands with Visible Light

Rajgopal Sharma, Jessica D. Knoll, Nicholas Ancona, Phillip D. Martin, Claudia Turro and Jeremy J. Kodanko

Inorg. Chem., 2015, 54, 1901
DOI: 10.1021/ic502791y

Copper(II) Pyridyl Aminophenolates: Hypoxia‐Selective, Nucleus‐Targeting Cytotoxins, and Magnetic Resonance Probes

Kathleen E. Prosser, Da Xie, Annica Chu, Gregory A. MacNeil, Bryton R. Varju, Rahul T. Kadakia, Emily L. Que and Charles J. Walsby

Chemistry A European J, 2021, 27, 9839
DOI: 10.1002/chem.202100603

Bioorthogonal Labeling, Bioimaging, and Photocytotoxicity Studies of Phosphorescent Ruthenium(II) Polypyridine Dibenzocyclooctyne Complexes

Tommy Siu‐Ming Tang, Alex Man‐Hei Yip, Kenneth Yin Zhang, Hua‐Wei Liu, Po Lam Wu, King Fai Li, Kok Wai Cheah and Kenneth Kam‐Wing Lo

Chemistry A European J, 2015, 21, 10729
DOI: 10.1002/chem.201501040

Lipophilic integrated bioorthogonal self-catalyzed nitric oxide donor–platinum(IV) prodrugs for enhanced antitumor efficacy against esophageal cancer

Ziyu Qian, Xun Yuan, Qing Zhao, Chi Zhang, Jia Shao, Lin Wang, Haoyang Tang, Zirui Su, Mengshuang Huang, Jiayi Xue, Chen Zhang, Huiqin Chen, Ummatjon Gayrat Ugli Mustafaev, Ziqi Pan, Hui Ye, Yihua Zhang, Zhangjian Huang, Shan Yang and Jianbing Wu

European Journal of Medicinal Chemistry, 2026, 301, 118221
DOI: 10.1016/j.ejmech.2025.118221

Protein Tyrosine Phosphatase Inhibition by Metals and Metal Complexes

Liping Lu and Miaoli Zhu

Antioxidants & Redox Signaling, 2014, 20, 2210
DOI: 10.1089/ars.2013.5720

Synthesis, spectral characterization and computed optical analysis of potent triazole based compounds

Sajjad H. Sumrra, Fazila Mushtaq, Muhammad Khalid, Muhammad Asam Raza, Muhammad Faizan Nazar, Bakhat Ali and Ataualpa A.C. Braga

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2018, 190, 197
DOI: 10.1016/j.saa.2017.09.019

Ruthenium(II) complexes of 1-(2-picolyl)-1,2,3-triazole-appended 2-arylbenzothiazoles: synthesis, characterization, in vitro and in silico evaluation of anti-proliferative activity

Silvio Jakopec, Napat Prompat, Lejla Ferhatovic Hamzic, Luka Bočkor, Mirela Sedić, Srećko I. Kirin, Dijana Jadreško and Silvana Raić-Malić

Inorganic Chemistry Communications, 2025, 182, 115627
DOI: 10.1016/j.inoche.2025.115627

Multicolor Labeling of Living‐Virus Particles in Live Cells

Peng Zhou, Zhenhua Zheng, Wen Lu, Fuxian Zhang, Zhenfeng Zhang, Daiwen Pang, Bin Hu, Zhike He and Hanzhong Wang

Angew Chem Int Ed, 2012, 51, 670
DOI: 10.1002/anie.201105701

Synthesis, structural characterization, in vitro DNA binding, and antitumor activity properties of Ru(II) compounds containing 2(2,6-dimethoxypyridine-3-yl)-1H-imidazo(4,5-f)[1, 10]phenanthroline

Nagamani Chintakuntla, Venkat Reddy Putta, Rajender Reddy Mallepally, Nagasuryaprasad K, Ravi Kumar Vuradi, Laxma Reddy Kotha, Satyanarayana Surya Singh and Satyanarayana Sirasani

Nucleosides, Nucleotides & Nucleic Acids, 2020, 39, 760
DOI: 10.1080/15257770.2019.1694685

Homo‐ and Heteroleptic Phototoxic Dinuclear Metallo‐Intercalators Based on RuII(dppn) Intercalating Moieties: Synthesis, Optical, and Biological Studies

Hiwa K. Saeed, Paul J. Jarman, Stuart Archer, Sreejesh Sreedharan, Ibrahim Q. Saeed, Luke K. Mckenzie, Julia A. Weinstein, Niklaas J. Buurma, Carl G. W. Smythe and Jim A. Thomas

Angewandte Chemie, 2017, 129, 12802
DOI: 10.1002/ange.201707350

Controlled Dual Activation of Rhenium(I) Photosensitizers and Profluorophores/Prodrugs via a Dissociative Bioorthogonal Tetrazine–Isonitrile Reaction

Eunice Chiu‐Lam Mak, Lawrence Cho‐Cheung Lee and Kenneth Kam‐Wing Lo

Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202516957

Influence of ligand lipophilicity in Pt(II) complexes on their antiproliferative and apoptotic activities in tumour cell lines

Elena Fernández-Delgado, Samuel Estirado, Javier Espino, Emilio Viñuelas-Zahínos, Francisco Luna-Giles, Ana B. Rodríguez Moratinos and José A. Pariente

Journal of Inorganic Biochemistry, 2022, 227, 111688
DOI: 10.1016/j.jinorgbio.2021.111688

Molecular Dynamics Simulation of 2-Benzimidazolyl-Urea with DPPC Lipid Membrane and Comparison with a Copper(II) Complex Derivative

Georgios Rossos, Sotiris K. Hadjikakou and Nikolaos Kourkoumelis

Membranes, 2021, 11, 743
DOI: 10.3390/membranes11100743

Bioorthogonal Postlabeling Reveals Nuclear Localization of a Highly Cytotoxic Half‐Sandwich Ir(III) Tetrazine Complex in Live Cells

Alfonso Annunziata, Sadek Amhaz, Jérémy Forté, Geoffrey Gontard, Romain Morichon, Joëlle Sobczak‐Thépot and Michèle Salmain

ChemBioChem, 2025, 26
DOI: 10.1002/cbic.202500090

Intracellular Dynamic Assembly of Deep‐Red Emitting Supramolecular Nanostructures Based on the Pt…Pt Metallophilic Interaction

Xue‐Quan Zhou, Maria Mytiliniou, Jonathan Hilgendorf, Ye Zeng, Panagiota Papadopoulou, Yang Shao, Maximilian Paradiz Dominguez, Liyan Zhang, Marcel B. S. Hesselberth, Erik Bos, Maxime A. Siegler, Francesco Buda, Albert M. Brouwer, Alexander Kros, Roman I. Koning, Doris Heinrich and Sylvestre Bonnet

Advanced Materials, 2021, 33
DOI: 10.1002/adma.202008613

Controlled Dual Activation of Rhenium(I) Photosensitizers and Profluorophores/Prodrugs via a Dissociative Bioorthogonal Tetrazine–Isonitrile Reaction

Eunice Chiu‐Lam Mak, Lawrence Cho‐Cheung Lee and Kenneth Kam‐Wing Lo

Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202516957

The periodic table of urea derivative: small molecules of zinc(II) and nickel(II) of diverse antimicrobial and antiproliferative applications

Christina N. Banti, Mehmet Poyraz, I. Sainis, Musa Sari, G. Rossos, N. Kourkoumelis and Sotiris K. Hadjikakou

Mol Divers, 2020, 24, 31
DOI: 10.1007/s11030-018-09909-0

Dual topoisomerase I and II poisoning by chiral Ru(II) complexes containing 2-thiophenylimidazo[4,5-f][1,10]phenanthroline derivatives

Yu-Chuan Wang, Chen Qian, Zai-Li Peng, Xiao-Juan Hou, Li-Li Wang, Hui Chao and Liang-Nian Ji

Journal of Inorganic Biochemistry, 2014, 130, 15
DOI: 10.1016/j.jinorgbio.2013.09.015

APPLICATION OF TECHNETIUM AND RHENIUM IN NUCLEAR MEDICINE

ROGER ALBERTO

COSMOS, 2012, 08, 83
DOI: 10.1142/S0219607712300019

A Glimpse in the Metal Ion Selectivity Rules: Zn(II), Cd(II) and Co(II) Interplay With Different Protein Coordination Spheres in Determining Variable Thermal Stability and Folding Scenarios

Martina Dragone, Gaetano Caputo, Gianluca D’Abrosca, Getasew Shitaye, Ilaria Baglivo, Paolo Vincenzo Pedone, Luigi Russo, Roberto Fattorusso, Gaetano Malgieri, Carla Isernia and Anastasios Keramidas

Bioinorganic Chemistry and Applications, 2026, 2026
DOI: 10.1155/bca/3380419

Tracking Antitumor Metallodrugs: Promising Agents with the Ru(II)- and Fe(II)-Cyclopentadienyl Scaffolds

Tânia S Morais, Andreia Valente, Ana Isabel Tomaz, Fernanda Marques and Maria Helena Garcia

Future Med. Chem., 2016, 8, 527
DOI: 10.4155/fmc.16.7

Mechanisms of Pharmaceutical Therapy and Drug Resistance in Esophageal Cancer

Chengyi Mao, Xiaoxi Zeng, Chao Zhang, Yushang Yang, Xin Xiao, Siyuan Luan, Yonggang Zhang and Yong Yuan

Front. Cell Dev. Biol., 2021, 9
DOI: 10.3389/fcell.2021.612451

Cyclometalated Iridium(III) Bipyridine–Phenylboronic Acid Complexes as Bioimaging Reagents and Luminescent Probes for Sialic Acids

Hua‐Wei Liu, Wendell Ho‐Tin Law, Lawrence Cho‐Cheung Lee, Jonathan Chun‐Wai Lau and Kenneth Kam‐Wing Lo

Chemistry An Asian Journal, 2017, 12, 1545
DOI: 10.1002/asia.201700359

Evaluation of the Medicinal Potential of Two Ruthenium(II) Polypyridine Complexes as One‐ and Two‐Photon Photodynamic Therapy Photosensitizers

Jeannine Hess, Huaiyi Huang, Adrian Kaiser, Vanessa Pierroz, Olivier Blacque, Hui Chao and Gilles Gasser

Chemistry A European J, 2017, 23, 9888
DOI: 10.1002/chem.201701392

Cellular Uptake Mechanisms of an Antitumor Ruthenium Compound: The Endosomal/Lysosomal System as a Target for Anticancer Metal-Based Drugs

Leonor Côrte-Real, António P. Matos, Irina Alho, Tânia S. Morais, Ana Isabel Tomaz, Maria Helena Garcia, Isabel Santos, Manuel P. Bicho and Fernanda Marques

Microsc Microanal, 2013, 19, 1122
DOI: 10.1017/S143192761300175X

Polymer encapsulation of ruthenium complexes for biological and medicinal applications

Elise Villemin, Yih Ching Ong, Christophe M. Thomas and Gilles Gasser

Nat Rev Chem, 2019, 3, 261
DOI: 10.1038/s41570-019-0088-0

The in vitro apoptotic effect of new zinc complex possessing folic acid and phenanthroline on cervix cancer cells

Liyun Yang, Mostafa Heidari Majd, Fereshteh Shiri, Somaye Shahraki and Pouya Karimi

Applied Organom Chemis, 2022, 36
DOI: 10.1002/aoc.6525

In Vitro Analysis of Heavy Metal Adsorption by Zeolite Skin Care Formulations Using a Quality by Design Approach

Alessandro Nencioni, Michela Bulfoni and Emanuele Nencioni

Materials, 2026, 19, 685
DOI: 10.3390/ma19040685

Utilizing coordination chemistry through formation of a CuII-quinalizarin complex to manipulate cell biology: An in vitro, in silico approach

Sayantani Chatterjee, Chetan Kumar Jain, Tanmoy Saha, Susanta Roychoudhury, Hemanta Kumar Majumder and Saurabh Das

Journal of Inorganic Biochemistry, 2023, 249, 112369
DOI: 10.1016/j.jinorgbio.2023.112369

Diketonato based ferrocene appended cyclometalated iridium(III) complexes: Anti-microbial and anti-cancer studies

Nedunchezhian Kavitha, Vijayan Thamilarasan and Nallathambi Sengottuvelan

Journal of Organometallic Chemistry, 2021, 952, 122032
DOI: 10.1016/j.jorganchem.2021.122032

Modifying Charge and Hydrophilicity of Simple Ru(II) Polypyridyl Complexes Radically Alters Biological Activities: Old Complexes, Surprising New Tricks

Matthew Dickerson, Yang Sun, Brock Howerton and Edith C. Glazer

Inorg. Chem., 2014, 53, 10370
DOI: 10.1021/ic5013796

Homo‐ and Heteroleptic Phototoxic Dinuclear Metallo‐Intercalators Based on RuII(dppn) Intercalating Moieties: Synthesis, Optical, and Biological Studies

Hiwa K. Saeed, Paul J. Jarman, Stuart Archer, Sreejesh Sreedharan, Ibrahim Q. Saeed, Luke K. Mckenzie, Julia A. Weinstein, Niklaas J. Buurma, Carl G. W. Smythe and Jim A. Thomas

Angew Chem Int Ed, 2017, 56, 12628
DOI: 10.1002/anie.201707350

Bioactive Luminescent Transition‐Metal Complexes for Biomedical Applications

Dik‐Lung Ma, Hong‐Zhang He, Ka‐Ho Leung, Daniel Shiu‐Hin Chan and Chung‐Hang Leung

Angew Chem Int Ed, 2013, 52, 7666
DOI: 10.1002/anie.201208414

Dinuclear polypyridylruthenium(II) complexes: flow cytometry studies of their accumulation in bacteria and the effect on the bacterial membrane

F. Li, M. Feterl, J. M. Warner, F. R. Keene and J. G. Collins

Journal of Antimicrobial Chemotherapy, 2013, 68, 2825
DOI: 10.1093/jac/dkt279

Peptide Nucleic Acid Conjugated with Ruthenium‐Complex Stabilizing Double‐Duplex Invasion Complex Even under Physiological Conditions

Masaki Hibino, Yuichiro Aiba, Yoshihito Watanabe and Osami Shoji

ChemBioChem, 2018, 19, 1601
DOI: 10.1002/cbic.201800256

Two isostructural Co(II) flufenamato and niflumato complexes with bathocuproine: Analogues with a different cytotoxic activity

Lukáš Smolko, Romana Smolková, Erika Samoľová, Ibrahim Morgan, Mohamad Saoud and Goran N. Kaluđerović

Journal of Inorganic Biochemistry, 2020, 210, 111160
DOI: 10.1016/j.jinorgbio.2020.111160

Structural Manipulation of Ruthenium(II) Polypyridine Nitrone Complexes to Generate Phosphorogenic Bioorthogonal Reagents for Selective Cellular Labeling

Tommy Siu‐Ming Tang, Hua‐Wei Liu and Kenneth Kam‐Wing Lo

Chemistry A European J, 2016, 22, 9649
DOI: 10.1002/chem.201601332

Correlation Between Cellular Localization and Binding Preference to RNA, DNA, and Phospholipid Membrane for Luminescent Ruthenium(II) Complexes

Maria Matson, Frida R. Svensson, Bengt Nordén and Per Lincoln

J. Phys. Chem. B, 2011, 115, 1706
DOI: 10.1021/jp109530f

Importance of Metal-Ion Exchange for the Biological Activity of Coordination Complexes of the Biomimetic Ligand N4Py

Arjan Geersing, Nathalie Ségaud, Monique G. P. van der Wijst, Marianne G. Rots and Gerard Roelfes

Inorg. Chem., 2018, 57, 7748
DOI: 10.1021/acs.inorgchem.8b00714

Delaying Photobleaching of a Light-Switch Complex for Real-Time Imaging of Single Viral Particle Uncoating

Yingxin Ma, Zongqiang Cui, Zhike He, Wei Li, Zhiping Zhang, Xiaowei Zhang, Xian-En Zhang and Tianwei Tan

Anal. Chem., 2016, 88, 10675
DOI: 10.1021/acs.analchem.6b03127

Localization of ZIP14 and ZIP8 in HIBCPP Cells

Shannon E. Morgan, Horst Schroten, Hiroshi Ishikawa and Ningning Zhao

Brain Sciences, 2020, 10, 534
DOI: 10.3390/brainsci10080534

Water-Soluble Co(III) Complexes of Substituted Phenanthrolines with Cell Selective Anticancer Activity

Sivaraman Jagadeesan, Vimalkumar Balasubramanian, Patric Baumann, Markus Neuburger, Daniel Häussinger and Cornelia G. Palivan

Inorg. Chem., 2013, 52, 12535
DOI: 10.1021/ic4016228

Monochalcoplatin: An Actively Transported, Quickly Reducible, and Highly Potent PtIV Anticancer Prodrug

Lili Ma, Na Wang, Rong Ma, Cai Li, Zoufeng Xu, Man‐Kit Tse and Guangyu Zhu

Angew Chem Int Ed, 2018, 57, 9098
DOI: 10.1002/anie.201804314

Phosphorescence Imaging of Living Cells with Amino Acid-Functionalized Tris(2-phenylpyridine)iridium(III) Complexes

Peter Steunenberg, Albert Ruggi, Nynke S. van den Berg, Tessa Buckle, Joeri Kuil, Fijs W.B. van Leeuwen and Aldrik H. Velders

Inorg. Chem., 2012, 51, 2105
DOI: 10.1021/ic201860s

Catch and Release Photosensitizers: Combining Dual-Action Ruthenium Complexes with Protease Inactivation for Targeting Invasive Cancers

Karan Arora, Mackenzie Herroon, Malik H. Al-Afyouni, Nicholas P. Toupin, Thomas N. Rohrabaugh, Lauren M. Loftus, Izabela Podgorski, Claudia Turro and Jeremy J. Kodanko

J. Am. Chem. Soc., 2018, 140, 14367
DOI: 10.1021/jacs.8b08853

Low-Dose Near-Infrared Light-Activated Mitochondria-Targeting Photosensitizers for PDT Cancer Therapy

Wenyu Wu Klingler, Nadine Giger, Lukas Schneider, Vipin Babu, Christiane König, Patrick Spielmann, Roland H. Wenger, Stefano Ferrari and Bernhard Spingler

IJMS, 2022, 23, 9525
DOI: 10.3390/ijms23179525

Convenient Cyclopentadiene Modifications for Building Versatile (Radio‐)Metal Cyclopentadienyl Frameworks

Raphael Lengacher, Henrik Braband, Joshua Csucker and Roger Alberto

Eur J Inorg Chem, 2021, 2021, 1611
DOI: 10.1002/ejic.202100163

Effect of Lanthanide Complex Structure on Cell Viability and Association

Katie L. Peterson, Jonathan V. Dang, Evan A. Weitz, Cutler Lewandowski and Valérie C. Pierre

Inorg. Chem., 2014, 53, 6013
DOI: 10.1021/ic500282n

A Dinuclear Ruthenium(II) Complex as a One‐ and Two‐Photon Luminescent Probe for Biological Cu2+ Detection

Pingyu Zhang, Lingmin Pei, Yu Chen, Wenchao Xu, Qitian Lin, Jinquan Wang, Jingheng Wu, Yong Shen, Liangnian Ji and Hui Chao

Chemistry A European J, 2013, 19, 15494
DOI: 10.1002/chem.201302919

Organometallic ruthenium(II)-arene complexes with triphenylphosphine amino acid bioconjugates: Synthesis, characterization and biological properties

Margareta Pernar, Zoran Kokan, Juran Kralj, Zoran Glasovac, Lidija-Marija Tumir, Ivo Piantanida, Domagoj Eljuga, Iztok Turel, Anamaria Brozovic and Srećko I. Kirin

Bioorganic Chemistry, 2019, 87, 432
DOI: 10.1016/j.bioorg.2019.03.048

Interactions of Cationic Diruthenium Trithiolato Complexes with Phospholipid Membranes Studied by NMR Spectroscopy

Hedvika Primasová, Martina Vermathen and Julien Furrer

J. Phys. Chem. B, 2020, 124, 8822
DOI: 10.1021/acs.jpcb.0c05133

Sara Seršen, Jakob Kljun, Kushtrim Kryeziu, Rostyslav Panchuk, Beatrix Alte, Wilfried Körner, Petra Heffeter, Walter Berger and Iztok Turel

J. Med. Chem., 2015, 58, 3984
DOI: 10.1021/acs.jmedchem.5b00288

Neutral Re(I) Complex Platform for Live Intracellular Imaging

Todd A. Gillam, Chiara Caporale, Robert D. Brooks, Christie A. Bader, Alexandra Sorvina, Melissa V. Werrett, Phillip J. Wright, Janna L. Morrison, Massimiliano Massi, Doug A. Brooks, Stefano Zacchini, Shane M. Hickey, Stefano Stagni and Sally E. Plush

Inorg. Chem., 2021, 60, 10173
DOI: 10.1021/acs.inorgchem.1c00418

8-Hydroxyquinoline ruthenium(II) complexes induce ferroptosis in HeLa cells by down-regulating GPX4 and ferritin

Minying Huang, Yuqing Zhang, Yao Gong, Zhijun Liang, Xide Chen, Yunxin Ni, Xinjie Pan, Wei Wu, Jiaxi Chen, Zunnan Huang and Jing Sun

Journal of Inorganic Biochemistry, 2023, 248, 112365
DOI: 10.1016/j.jinorgbio.2023.112365

Characterization of [Ru(bpy)2(diamine)]2+ complexes and their DNA binding and cleavage, BSA interaction, cytotoxic, and anticancer mechanistic properties

Mariappan Murali, Jegaratchagan Latha, Pitchan Arul Prakash, Somasundaram Sangeetha, Balasubramaniam Selvakumaran and Mohamed Sultan Mohamed Jaabir

Polyhedron, 2022, 223, 115925
DOI: 10.1016/j.poly.2022.115925

Cellular localization of iron(II) polypyridyl complexes determines their anticancer action mechanisms

Jingjing Chen, Zuandi Luo, Zhennan Zhao, Lina Xie, Wenjie Zheng and Tianfeng Chen

Biomaterials, 2015, 71, 168
DOI: 10.1016/j.biomaterials.2015.08.031

Bis(dipyridophenazine)(2‐(2′‐pyridyl)pyrimidine‐4‐carboxylic acid)ruthenium(II) Hexafluorophosphate: A Lesson in Stubbornness

Tanmaya Joshi, Vanessa Pierroz, Stefano Ferrari and Gilles Gasser

ChemMedChem, 2014, 9, 1419
DOI: 10.1002/cmdc.201400029

Multicolor Labeling of Living‐Virus Particles in Live Cells

Peng Zhou, Zhenhua Zheng, Wen Lu, Fuxian Zhang, Zhenfeng Zhang, Daiwen Pang, Bin Hu, Zhike He and Hanzhong Wang

Angewandte Chemie, 2012, 124, 694
DOI: 10.1002/ange.201105701

Tuning the Biological Activity of Camphorimine Complexes through Metal Selection

Joana P. Costa, Teresa Pinheiro, Maria S. Martins, M. Fernanda N. N. Carvalho, Joana R. Feliciano, Jorge H. Leitão, Rafaela A. L. Silva, Joana F. Guerreiro, Luís M. C. Alves, Inês Custódio, João Cruz and Fernanda Marques

Antibiotics, 2022, 11, 1010
DOI: 10.3390/antibiotics11081010

Ursolic acid-piperazine-dithiocarbamate ruthenium(II) polypyridyl complexes induced necroptosis in MGC-803 cells

Hong Jiang, Jian-Hua Wei, Cui-Yan Lin, Gui-Bin Liang, Rui-Jie He, Ri-Zhen Huang, Xian-Li Ma, Guo-Bao Huang and Ye Zhang

Metallomics, 2022, 14
DOI: 10.1093/mtomcs/mfac072

Sensing Amyloid-β Aggregation Using Luminescent Dipyridophenazine Ruthenium(II) Complexes

Nathan P. Cook, Veronica Torres, Disha Jain and Angel A. Martí

J. Am. Chem. Soc., 2011, 133, 11121
DOI: 10.1021/ja204656r

Photophysical properties of benzo[i]dipyrido[3,2-a:2′,3′-c] phenazine (dppn) – A prospective ligand for light-activated anticancer complexes

V.A. Meshcheryakova, V.P. Grivin, A.V. Mikheylis, Yu.P. Tsentalovich, A.A. Kokorenko, I.P. Pozdnyakov, K.S. Ershov, A.V. Baklanov, A.E. Zazulya, D.B. Vasilchenko, A.A. Melnikov, S.V. Chekalin and E.M. Glebov

Journal of Luminescence, 2024, 275, 120804
DOI: 10.1016/j.jlumin.2024.120804

A ruthenium(II) complex capable of inducing and stabilizing bcl-2 G-quadruplex formation as a potential cancer inhibitor

Jingnan Zhang, Qianqian Yu, Qian Li, Licong Yang, Lanmei Chen, Yanhui Zhou and Jie Liu

Journal of Inorganic Biochemistry, 2014, 134, 1
DOI: 10.1016/j.jinorgbio.2013.12.005

Dual Functional Half‐Sandwich Ru(II) Complexes: Lysosome‐Targeting Probes and Anticancer Agents

Zhe Liu, JuanJuan Li, Deliang Kong, Meng Tian, Yao Zhao, Zhishan Xu, Wenyuan Gao and Yumin Zhou

Eur J Inorg Chem, 2019, 2019, 287
DOI: 10.1002/ejic.201801339

Ruthenium(II) polypyridyl complexes: Cellular uptake, cell image and apoptosis of HeLa cancer cells induced by double targets

Qianqian Yu, Yanan Liu, Lei Xu, Chuping Zheng, Fangling Le, Xiuying Qin, Yanyu Liu and Jie Liu

European Journal of Medicinal Chemistry, 2014, 82, 82
DOI: 10.1016/j.ejmech.2014.05.040

Synthesis of CpM(CO)3–DAB and –PAMAM Dendrimer Conjugates and Preliminary Evaluation of Their Biological Activity

Wanning Hu, Jan Hoyer, Ines Neundorf, Preshendren Govender, Gregory S. Smith and Ulrich Schatzschneider

Eur J Inorg Chem, 2015, 2015, 1505
DOI: 10.1002/ejic.201403060

Nuclear Permeable Ruthenium(II) β-Carboline Complexes Induce Autophagy To Antagonize Mitochondrial-Mediated Apoptosis

Caiping Tan, Sensen Lai, Shouhai Wu, Sheng Hu, Lingjun Zhou, Yu Chen, Minxu Wang, Yiping Zhu, Wu Lian, Wenlie Peng, Liangnian Ji and Anlong Xu

J. Med. Chem., 2010, 53, 7613
DOI: 10.1021/jm1009296

Synthesis, characterization and interactions with the oligonucleotide d(5′-CGCGAATTCGCG-3′)2, of bis(terpyridine)ruthenium(II)–peptide conjugates

Konstantinos Ypsilantis, Spyridon Karkabounas, Elena Georgiou, Ioannis Zelovitis and Achilleas Garoufis

Inorganica Chimica Acta, 2014, 421, 152
DOI: 10.1016/j.ica.2014.05.042

Synthesis and characterization of acrylate cyanide bridged dimeric fac-Rhenium(I) complex: Photophysical, selective CO2 adsorption and theoretical studies

Debopam Sinha, Sankar Prasad Parua and Kajal Krishna Rajak

Journal of Organometallic Chemistry, 2019, 889, 62
DOI: 10.1016/j.jorganchem.2019.03.014

Introduction of 1,3-diethyl-4,5-diphenyl-4,5-dihydro-1H-imidazol-2-ylidene as new ligand for the design of antitumor-active (NHC)gold(I) complexes: An approach to reduce ligand scrambling and to increase tumor cell selectivity

Amelie Scherfler, Stefan Schwaiger, Klaus Wurst, Brigitte Kircher, Daniel Baecker and Ronald Gust

European Journal of Medicinal Chemistry, 2025, 299, 117919
DOI: 10.1016/j.ejmech.2025.117919

Intracellular Photocatalytic NADH/NAD(P)H Oxidation for Cancer Drug Development

Ashish Kumar Yadav, Rajesh Kushwaha, Arif Ali Mandal, Apurba Mandal and Samya Banerjee

J. Am. Chem. Soc., 2025, 147, 7161
DOI: 10.1021/jacs.4c18328

Polycationic Ru(II) Luminophores: Syntheses, Photophysics, and Application in Electrostatically Driven Sensitization of Lanthanide Luminescence

Richard C. Knighton, Joseph M. Beames and Simon J. A. Pope

Inorg. Chem., 2023, 62, 19446
DOI: 10.1021/acs.inorgchem.3c02352

Heterometallic Ru–Pt metallacycle for two-photon photodynamic therapy

Zhixuan Zhou, Jiangping Liu, Thomas W. Rees, Heng Wang, Xiaopeng Li, Hui Chao and Peter J. Stang

Proc. Natl. Acad. Sci. U.S.A., 2018, 115, 5664
DOI: 10.1073/pnas.1802012115

Studies on Photocleavage, DNA Binding, Cytotoxicity, and Docking Studies of Ruthenium(II) Mixed Ligand Complexes

Yata Praveen Kumar, C. Shobha Devi, A. Srishailam, N. Deepika, V. Ravi Kumar, P. Venkat Reddy, K Nagasuryaprasad, Surya S. Singh, Penumaka Nagababu and S. Satyanarayana

J Fluoresc, 2016, 26, 2119
DOI: 10.1007/s10895-016-1908-y

Ruthenium complexes with phenylterpyridine derivatives target cell membrane and trigger death receptors-mediated apoptosis in cancer cells

Zhiqin Deng, Pan Gao, Lianling Yu, Bin Ma, Yuanyuan You, Leung Chan, Chaoming Mei and Tianfeng Chen

Biomaterials, 2017, 129, 111
DOI: 10.1016/j.biomaterials.2017.03.017

FALCON-qPCR: a new method for the quantification of oxidative lesions in mitochondrial DNA

Veronica Bazzani, Eve Harding, Szymon Balinski, Mara Equisoain Redin, Dario Alessi, Pierfrancesco Del Mestre, Walter Baratta, Daniela Cesselli, Antonio Paolo Beltrami, Michał Turek, Umberto Baccarani and Carlo Vascotto

Bioanalysis, 2025, 17, 1671
DOI: 10.1080/17576180.2025.2608757

New NSAID-Pt(IV) prodrugs to suppress metastasis and invasion of tumor cells and enhance anti-tumor effect in vitro and in vivo

Xue-Qing Song, Zhong-Ying Ma, Yi-Gang Wu, Miao-Liang Dai, Dong-Bo Wang, Jing-Yuan Xu and Yangzhong Liu

European Journal of Medicinal Chemistry, 2019, 167, 377
DOI: 10.1016/j.ejmech.2019.02.041

MeXpose─A Modular Imaging Pipeline for the Quantitative Assessment of Cellular Metal Bioaccumulation

Gabriel Braun, Martin Schaier, Paulina Werner, Sarah Theiner, Jürgen Zanghellini, Lukas Wisgrill, Nanna Fyhrquist and Gunda Koellensperger

JACS Au, 2024, 4, 2197
DOI: 10.1021/jacsau.4c00154

Characterisation and proteomic profiling of continuously exposed Cu-resistant variants of the Caco-2 cell line

Charles O'Doherty, Joanne Keenan, Michael Henry, Paula Meleady, Indre Sinkunaite, Martin Clynes, Finbarr O'Sullivan, Karina Horgan and Richard Murphy

Toxicology in Vitro, 2020, 65, 104773
DOI: 10.1016/j.tiv.2020.104773

The role of folic acid in inducing of apoptosis by zinc(II) complex in ovary and cervix cancer cells

Chuanrong Yu, Mostafa Heidari Majd, Fereshteh Shiri, Somaye Shahraki and Pouya Karimi

Mol Divers, 2022, 26, 1545
DOI: 10.1007/s11030-021-10293-5

Covalent and non-covalent binding of metal complexes to RNA

Elena Alberti, Marianthi Zampakou and Daniela Donghi

Journal of Inorganic Biochemistry, 2016, 163, 278
DOI: 10.1016/j.jinorgbio.2016.04.021

In Vitro Anticancer Activity and in Vivo Biodistribution of Rhenium(I) Tricarbonyl Aqua Complexes

Kevin M. Knopf, Brendan L. Murphy, Samantha N. MacMillan, Jeremy M. Baskin, Martin P. Barr, Eszter Boros and Justin J. Wilson

J. Am. Chem. Soc., 2017, 139, 14302
DOI: 10.1021/jacs.7b08640

On the shuttling across the blood-brain barrier via tubule formation: Mechanism and cargo avidity bias

Xiaohe Tian, Diana M. Leite, Edoardo Scarpa, Sophie Nyberg, Gavin Fullstone, Joe Forth, Diana Matias, Azzurra Apriceno, Alessandro Poma, Aroa Duro-Castano, Manish Vuyyuru, Lena Harker-Kirschneck, Anđela Šarić, Zhongping Zhang, Pan Xiang, Bin Fang, Yupeng Tian, Lei Luo, Loris Rizzello and Giuseppe Battaglia

Sci. Adv., 2020, 6
DOI: 10.1126/sciadv.abc4397

Schiff Base Metal Organic Frameworks for Biological Applications - A Review

Vinuta Kamat, Geetika Pant, Basappa C. Yallur, S. G. Prasanna Kumar, Vinayak M. Adimule and Sheetal R. Batakurki

jmmf, 2024, 421
DOI: 10.18311/jmmf/2023/43604

Impedance technology reveals correlations between cytotoxicity and lipophilicity of mono and bimetallic phosphine complexes

P. Fonteh, A. Elkhadir, B. Omondi, I. Guzei, J. Darkwa and D. Meyer

Biometals, 2015, 28, 653
DOI: 10.1007/s10534-015-9851-y

Organoruthenium Complexes with Benzo-Fused Pyrithiones Overcome Platinum Resistance in Ovarian Cancer Cells

Jerneja Kladnik, James P. C. Coverdale, Jakob Kljun, Hilke Burmeister, Petra Lippman, Francesca G. Ellis, Alan M. Jones, Ingo Ott, Isolda Romero-Canelón and Iztok Turel

Cancers, 2021, 13, 2493
DOI: 10.3390/cancers13102493

A ruthenium(II) complex binds protein and inhibits proliferation and induces apoptosis in human gastric cancer SGC-7901 cells

Si-Hong Liu, Hui-Hua Xu, Jian-Wei Zhu, Yan Wang, Ya-Min Liu, Jun-Bo Liang, Gui-Qiang Zhang, Di-Hua Cao, Yang-Yang Lin, Qi-Feng Guo and Yong Wu

Polyhedron, 2016, 105, 12
DOI: 10.1016/j.poly.2015.11.052

Polymeric Micelle‐Mediated Delivery of DNA‐Targeting Organometallic Complexes for Resistant Ovarian Cancer Treatment

Xiaopin Duan, Demin Liu, Christina Chan and Wenbin Lin

Small, 2015, 11, 3962
DOI: 10.1002/smll.201500288

When are metal complexes bioavailable?

Chun-Mei Zhao, Peter G.C. Campbell and Kevin J. Wilkinson

Environmental Chemistry, 2016, 13, 425
DOI: 10.1071/EN15205

Ruthenium(II) polypyridyl complexes with 1,8-naphthalimide group as DNA binder, photonuclease, and dual inhibitors of topoisomerases I and IIα

Yanmei Sun, Jia Li, Hong Zhao and Lifeng Tan

Journal of Inorganic Biochemistry, 2016, 163, 88
DOI: 10.1016/j.jinorgbio.2016.04.028

The cell-permeable mitochondrial calcium uniporter inhibitor Ru265 preserves cortical neuron respiration after lethal oxygen glucose deprivation and reduces hypoxic/ischemic brain injury

Robyn J Novorolsky, Matthew Nichols, Jong S Kim, Evgeny V Pavlov, Joshua J Woods, Justin J Wilson and George S Robertson

J Cereb Blood Flow Metab, 2020, 40, 1172
DOI: 10.1177/0271678X20908523

Bright lights down under: Metal ion complexes turning the spotlight on metabolic processes at the cellular level

Todd A. Gillam, Martin J. Sweetman, Christie A. Bader, Janna L. Morrison, John D. Hayball, Doug A. Brooks and Sally E. Plush

Coordination Chemistry Reviews, 2018, 375, 234
DOI: 10.1016/j.ccr.2017.11.026

Iron(III) Catecholates for Cellular Imaging and Photocytotoxicity in Red Light

Uttara Basu, Ila Pant, Imran Khan, Akhtar Hussain, Paturu Kondaiah and Akhil R. Chakravarty

Chemistry An Asian Journal, 2014, 9, 2494
DOI: 10.1002/asia.201402207

In Vitro and in Vivo Fluorescent Imaging of a Monofunctional Chelated Platinum Complex Excitable Using Visible Light

Shengde Wu, Chengcheng Zhu, Changli Zhang, Zhen Yu, Weijiang He, Yafeng He, Yizhi Li, Jing Wang and Zijian Guo

Inorg. Chem., 2011, 50, 11847
DOI: 10.1021/ic201506y

Synthesis, structure and spectral characteristics of Ni(II), Pd(II) and Zn(II) complexes with N-(2-pyridinyl)morpholine-4-carbothioamide

S.I. Orysyk, V.V. Bon, V.I. Pekhnyo, Yu.L. Zborovskii, V.V. Orysyk and M.V. Vovk

Polyhedron, 2012, 38, 15
DOI: 10.1016/j.poly.2012.02.017

The role of the equatorial ligands for the redox behavior, mode of cellular accumulation and cytotoxicity of platinum(IV) prodrugs

Simone Göschl, Hristo P. Varbanov, Sarah Theiner, Michael A. Jakupec, Mathea S. Galanski and Bernhard K. Keppler

Journal of Inorganic Biochemistry, 2016, 160, 264
DOI: 10.1016/j.jinorgbio.2016.03.005

Recent Development of Copper (II) Complexes of Polypyridyl Ligands in Chemotherapy and Photodynamic Therapy

Jansi Rani J and Sovan Roy

ChemMedChem, 2023, 18
DOI: 10.1002/cmdc.202200652

Cyclic Peptide–Polymer Nanotubes as Efficient and Highly Potent Drug Delivery Systems for Organometallic Anticancer Complexes

Sophie C. Larnaudie, Johannes C. Brendel, Isolda Romero-Canelón, Carlos Sanchez-Cano, Sylvain Catrouillet, Joaquin Sanchis, James P. C. Coverdale, Ji-Inn Song, Abraha Habtemariam, Peter J. Sadler, Katrina A. Jolliffe and Sébastien Perrier

Biomacromolecules, 2018, 19, 239
DOI: 10.1021/acs.biomac.7b01491

Effect of Fluorination on the Structure and Anti-Trypanosoma cruzyActivity of Oxorhenium(V) Complexes withS,N,S-Tridentate Thiosemicarbazones and Benzoylthioureas. Synthesis and Structures of Technetium(V) Analogues

Federico Salsi, Gisele Bulhões Portapilla, Saskia Simon, Maximilian Roca Jungfer, Adelheid Hagenbach, Sérgio de Albuquerque and Ulrich Abram

Inorg. Chem., 2019, 58, 10129
DOI: 10.1021/acs.inorgchem.9b01260

Design, synthesis and evaluation of anticancer activity of ruthenium (II) polypyridyl complexes

Bing Tang, Dan Wan, Shang-Hai Lai, Hui-Hui Yang, Cheng Zhang, Xiu-Zhen Wang, Chuan-Chuan Zeng and Yun-Jun Liu

Journal of Inorganic Biochemistry, 2017, 173, 93
DOI: 10.1016/j.jinorgbio.2017.04.028

Targeting cancer cells through iron(III) complexes of di(picolyl)amine modified silica core–shell nanospheres

Gen-Ping Tao, Qiu-Yun Chen, Xia Yang, Kai-Di Zhao and Jing Gao

Colloids and Surfaces B: Biointerfaces, 2011, 86, 106
DOI: 10.1016/j.colsurfb.2011.03.026

Copper(II) Complexes with Tetradentate Piperazine-Based Ligands: DNA Cleavage and Cytotoxicity

Sebastian Doniz Kettenmann, Yvonne Nossol, Febee R. Louka, Julia R. Legrande, Elise Marine, Roland C. Fischer, Franz A. Mautner, Vinja Hergl, Nora Kulak and Salah S. Massoud

Inorganics, 2021, 9, 12
DOI: 10.3390/inorganics9020012

Inhibition of Cathepsin Activity in a Cell‐Based Assay by a Light‐Activated Ruthenium Compound

Tomasz Respondek, Rajgopal Sharma, Mackenzie K. Herroon, Robert N. Garner, Jessica D. Knoll, Eric Cueny, Claudia Turro, Izabela Podgorski and Jeremy J. Kodanko

ChemMedChem, 2014, 9, 1306
DOI: 10.1002/cmdc.201400081

Mitochondria-targeted cyclometalated iridium-β-carboline complexes as potent non-small cell lung cancer therapeutic agents

Jincan Chen, Xinhua Guo, Dunhui Li, Hong Tang, Jie Gao, Wenzhu Yu, Xufeng Zhu, Zirong Sun, Zunnan Huang and Lanmei Chen

Metallomics, 2023, 15
DOI: 10.1093/mtomcs/mfad035

A nucleus-directed bombesin derivative for targeted delivery of metallodrugs to cancer cells

Sílvia Barrabés, Iteng Ng-Choi, María Ángeles Martínez, Blanca R. Manzano, Félix A. Jalón, Gustavo Espino, Lidia Feliu, Marta Planas, Rafael de Llorens and Anna Massaguer

Journal of Inorganic Biochemistry, 2020, 212, 111214
DOI: 10.1016/j.jinorgbio.2020.111214

Combination of light and Ru(II) polypyridyl complexes: Recent advances in the development of new anticancer drugs

Luca Conti, Eleonora Macedi, Claudia Giorgi, Barbara Valtancoli and Vieri Fusi

Coordination Chemistry Reviews, 2022, 469, 214656
DOI: 10.1016/j.ccr.2022.214656

A Liposome Encapsulated Ruthenium Polypyridine Complex as a Theranostic Platform for Triple-Negative Breast Cancer

Jianliang Shen, Han-Cheon Kim, Joy Wolfram, Chaofeng Mu, Wei Zhang, Haoran Liu, Yan Xie, Junhua Mai, Hang Zhang, Zhi Li, Maria Guevara, Zong-Wan Mao and Haifa Shen

Nano Lett., 2017, 17, 2913
DOI: 10.1021/acs.nanolett.7b00132

Monochalcoplatin: An Actively Transported, Quickly Reducible, and Highly Potent PtIV Anticancer Prodrug

Lili Ma, Na Wang, Rong Ma, Cai Li, Zoufeng Xu, Man‐Kit Tse and Guangyu Zhu

Angewandte Chemie, 2018, 130, 9236
DOI: 10.1002/ange.201804314

Multimodal Probes: Superresolution and Transmission Electron Microscopy Imaging of Mitochondria, and Oxygen Mapping of Cells, Using Small-Molecule Ir(III) Luminescent Complexes

Jonathan R. Shewring, Ahmet J. Cankut, Luke K. McKenzie, Bethany J. Crowston, Stanley W. Botchway, Julia A. Weinstein, Elizabeth Edwards and Michael D. Ward

Inorg. Chem., 2017, 56, 15259
DOI: 10.1021/acs.inorgchem.7b02633

Photosensitive Ru(II) Complexes as Inhibitors of the Major Human Drug Metabolizing Enzyme CYP3A4

Nicholas Toupin, Sean J. Steinke, Sandeep Nadella, Ao Li, Thomas N. Rohrabaugh, Eric R. Samuels, Claudia Turro, Irina F. Sevrioukova and Jeremy J. Kodanko

J. Am. Chem. Soc., 2021, 143, 9191
DOI: 10.1021/jacs.1c04155

Unveiling the anticancer activity of ruthenium and iron complexes

Neppoliyan Kannan, Vidya Radhakrishnan and Arup Sinha

Inorganic Chemistry Communications, 2024, 165, 112512
DOI: 10.1016/j.inoche.2024.112512

Combining cisplatin and a STING agonist into one molecule for metalloimmunotherapy of cancer

Shuren Zhang, Dongfan Song, Wenhao Yu, Ji Li, Xiaoyu Wang, Yachao Li, Zihan Zhao, Qi Xue, Jing Zhao, Jie P Li and Zijian Guo

National Science Review, 2023, 11
DOI: 10.1093/nsr/nwae020

Targeting Nucleus DNA with a Cyclometalated Dipyridophenazineruthenium(II) Complex

Huaiyi Huang, Pingyu Zhang, Bole Yu, Yu Chen, Jinquan Wang, Liangnian Ji and Hui Chao

J. Med. Chem., 2014, 57, 8971
DOI: 10.1021/jm501095r

Transmembrane transport mechanism of n-hexadecane by Candida tropicalis: Kinetic study and proteomic analysis

Jian Li, Ying Xu, Quanwei Song, Shurong Zhang, Lin Xie and Jie Yang

Ecotoxicology and Environmental Safety, 2021, 209, 111789
DOI: 10.1016/j.ecoenv.2020.111789

Ruthenium polypyridyl complex-containing bioconjugates

Marta Martínez-Alonso and Gilles Gasser

Coordination Chemistry Reviews, 2021, 434, 213736
DOI: 10.1016/j.ccr.2020.213736

Environmental and occupational exposure of metals and female reproductive health

Sulagna Dutta, Bapi Gorain, Hira Choudhury, Shubhadeep Roychoudhury and Pallav Sengupta

Environ Sci Pollut Res, 2022, 29, 62067
DOI: 10.1007/s11356-021-16581-9

Subcellular Localization and Transport Kinetics of Ruthenium Organometallic Anticancer Compounds in Living Cells: A Dose-Dependent Role for Amino Acid and Iron Transporters

M. Klajner, C. Licona, L. Fetzer, P. Hebraud, G. Mellitzer, M. Pfeffer, S. Harlepp and C. Gaiddon

Inorg. Chem., 2014, 53, 5150
DOI: 10.1021/ic500250e

Synthesis, spectral properties and DNA binding and nuclease activity of lanthanide (III) complexes of 2-benzoylpyridine benzhydrazone: X-ray crystal structure, Hirshfeld studies and nitrate-π interactions of cerium(III) complex

KARREDDULA RAJA, AKKILI SUSEELAMMA and KATREDDI HUSSAIN REDDY

J Chem Sci, 2016, 128, 23
DOI: 10.1007/s12039-015-1003-y

Cytotoxicity and mechanism of action of metal complexes: An overview

Sara Abdolmaleki, Samad Khaksar, Alireza Aliabadi, Akram Panjehpour, Elham Motieiyan, Domenica Marabello, Mohammad Hossein Faraji and Maria Beihaghi

Toxicology, 2023, 492, 153516
DOI: 10.1016/j.tox.2023.153516

Insights into the anticancer photodynamic activity of Ir(III) and Ru(II) polypyridyl complexes bearing β-carboline ligands

Juan Sanz-Villafruela, Cristina Bermejo-Casadesus, Elisenda Zafon, Marta Martínez-Alonso, Gema Durá, Aranzazu Heras, Iván Soriano-Díaz, Angelo Giussani, Enrique Ortí, Francesc Tebar, Gustavo Espino and Anna Massaguer

European Journal of Medicinal Chemistry, 2024, 276, 116618
DOI: 10.1016/j.ejmech.2024.116618

Luminescent Ruthenium(II) Polypyridyl Functionalized Gold Nanoparticles; Their DNA Binding Abilities and Application As Cellular Imaging Agents

Robert B. P. Elmes, Kim N. Orange, Suzanne M. Cloonan, D. Clive Williams and Thorfinnur Gunnlaugsson

J. Am. Chem. Soc., 2011, 133, 15862
DOI: 10.1021/ja2061159

DNA binding, photocleavage and topoisomerase inhibitory activity of polypyridyl ruthenium(II) complexes containing the same ancillary ligand and different main ligands

Xiaojun He, Leli Zeng, Guang Yang, Lingjun Xie, Xiaonan Sun and Lifeng Tan

Inorganica Chimica Acta, 2013, 408, 9
DOI: 10.1016/j.ica.2013.08.010

Ruthenium(II) Metallo‐intercalators: DNA Imaging and Cytotoxicity

Martin R. Gill, Hanan Derrat, Carl G. W. Smythe, Giuseppe Battaglia and Jim A. Thomas

ChemBioChem, 2011, 12, 877
DOI: 10.1002/cbic.201000782

Targeting ROS-AMPK pathway by multiaction Platinum(IV) prodrugs containing hypolipidemic drug bezafibrate

Xin Qiao, Yu-Yang Gao, Li-Xia Zheng, Xiao-Jing Ding, Ling-Wen Xu, Juan-Juan Hu, Wei-Zhen Gao and Jing-Yuan Xu

European Journal of Medicinal Chemistry, 2021, 223, 113730
DOI: 10.1016/j.ejmech.2021.113730

Impact of Metal Ions on Cellular Functions: A Focus on Mesenchymal Stem/Stromal Cell Differentiation

Kirsten Peters, Susanne Staehlke, Henrike Rebl, Anika Jonitz-Heincke and Olga Hahn

IJMS, 2024, 25, 10127
DOI: 10.3390/ijms251810127

2-Nitroimidazole-ruthenium polypyridyl complex as a new conjugate for cancer treatment and visualization

Olga Mazuryk, Monika Maciuszek, Grażyna Stochel, Franck Suzenet and Małgorzata Brindell

Journal of Inorganic Biochemistry, 2014, 134, 83
DOI: 10.1016/j.jinorgbio.2014.02.001

Photophysics and Cell Uptake of Self-Assembled Ru(II)Polypyridyl Vesicles

Stephen Finn, Aisling Byrne, Karmel S. Gkika and Tia E. Keyes

Front. Chem., 2020, 8
DOI: 10.3389/fchem.2020.00638

A Heteroleptic/Trimetallic OsII–RuII–ZnII Sierpiński Triangle for Efficient Photodynamic Therapy of Hypoxic Tumors Mainly through Type I Mechanism

Huan Qin, Qiaolin Chen, Bangtang Chen, Jun Wang, Huilin Su, Xiaojie Huang, Qiangqiang Dong, Mingzhao Chen, Zhimin Jiang, Yingying Li, Pingshan Wang and Zhilong Jiang

J. Am. Chem. Soc., 2025, 147, 23957
DOI: 10.1021/jacs.5c07313

Choline and Ethanolamine Plasmalogens Prevent Lead-Induced Cytotoxicity and Lipid Oxidation in HepG2 Cells

Yue Wu, Zhen Chen, Wageh S. Darwish, Koh Terada, Hitoshi Chiba and Shu-Ping Hui

J. Agric. Food Chem., 2019, 67, 7716
DOI: 10.1021/acs.jafc.9b02485

Histone‐Deacetylase‐Targeted Fluorescent Ruthenium(II) Polypyridyl Complexes as Potent Anticancer Agents

Rui‐Rong Ye, Zhuo‐Feng Ke, Cai‐Ping Tan, Liang He, Liang‐Nian Ji and Zong‐Wan Mao

Chemistry A European J, 2013, 19, 10160
DOI: 10.1002/chem.201300814

Unambiguous Intracellular Localization and Quantification of a Potent Iridium Anticancer Compound by Correlative 3D Cryo X‐Ray Imaging

José Javier Conesa, Ana C. Carrasco, Vanessa Rodríguez‐Fanjul, Yang Yang, José L. Carrascosa, Peter Cloetens, Eva Pereiro and Ana M. Pizarro

Angew Chem Int Ed, 2020, 59, 1270
DOI: 10.1002/anie.201911510

Unambiguous Intracellular Localization and Quantification of a Potent Iridium Anticancer Compound by Correlative 3D Cryo X‐Ray Imaging

José Javier Conesa, Ana C. Carrasco, Vanessa Rodríguez‐Fanjul, Yang Yang, José L. Carrascosa, Peter Cloetens, Eva Pereiro and Ana M. Pizarro

Angewandte Chemie, 2020, 132, 1286
DOI: 10.1002/ange.201911510

A Novel Organometallic ReI Complex with Favourable Properties for Bioimaging and Applicability in Solid‐Phase Peptide Synthesis

Lukasz Raszeja, Abdelouahid Maghnouj, Stephan Hahn and Nils Metzler‐Nolte

ChemBioChem, 2011, 12, 371
DOI: 10.1002/cbic.201000576

More-Is-Better Strategy for Constructing Homoligand Polypyridyl Ruthenium Complexes as Photosensitizers for Infrared Two-Photon Photodynamic Therapy

Shi-Jie Tang, Meng-Fan Wang, Rong Yang, Meng Liu, Qing-Fang Li and Feng Gao

Inorg. Chem., 2023, 62, 8210
DOI: 10.1021/acs.inorgchem.3c00585