Issue 5, 2023

Mussel-inspired adhesive hydrogels for local immunomodulation

Abstract

The important function of the immune system is to protect the body from foreign pathogens and tumor cells, and to participate in the process of tissue repair and anti-tumor activity to achieve homeostasis. Systemic administration of immune biological agents (cytokines, drugs, peptides, etc.) helps promote tissue repair, eliminate tumors, and treat autoimmune diseases. However, systemic administration has low specificity for target tissues, resulting in unexpected consequences, such as hypoactive or hyperactive immune activity of non-target tissues, leading to autoimmune complications. To overcome these problems, recently, local immunomodulatory strategies based on adhesive hydrogels have been developed. One such strategy is mussel-inspired adhesive hydrogels, which have robust bioadhesiveness and can adhere to the expected target sites to provide local, long-term controlled release of immune biological agents, thus potentially maximizing the therapeutic efficacy and limiting the impact on the overall immune balance. In addition, mussel-inspired adhesive hydrogels show regulatory effects on local immune cells through catechol groups. Therefore, a variety of mussel-inspired hydrogels have been developed to achieve the desired therapeutic effects through local immunoregulation strategies. In this review, the current state of knowledge regarding the immune response in tissue repair and tumor therapy is introduced. Subsequently, strategies for the design of adhesive hydrogels are summarized. Subsequently, the rational molecular structure design of mussel-inspired adhesive hydrogels for robust tissue adhesiveness, as well as their local immunomodulatory mechanism, is discussed. Furthermore, the local immunomodulatory effects of mussel-inspired adhesive hydrogels in different biomedical applications are summarized. Finally, the challenges and prospects for the future design of mussel-inspired adhesive hydrogels for local immunomodulation are highlighted.

Graphical abstract: Mussel-inspired adhesive hydrogels for local immunomodulation

Article information

Article type
Review Article
Submitted
26 ноя 2022
Accepted
07 ғин 2023
First published
13 ғин 2023

Mater. Chem. Front., 2023,7, 846-872

Mussel-inspired adhesive hydrogels for local immunomodulation

C. Xie, Y. Li, X. Guo, Y. Ding, X. Lu and S. Rao, Mater. Chem. Front., 2023, 7, 846 DOI: 10.1039/D2QM01232D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements