Issue 26, 2020

Cell membrane-engineered hybrid soft nanocomposites for biomedical applications

Abstract

Cell membrane-engineered nanoparticles, integrating the functions of the natural cell membrane and synthetic nanoparticles, are of great interest in various biomedical applications. In particular, cell membrane-engineered hybrid soft nanocomposites (CMHSNCs) with the core of degradable macromolecules or biofunctional molecules, and the shell of various types of functional cell membranes exhibited superior biocompatibility, prolonged circulation and enhanced targeting. They have been explored for cancer therapy, bioimaging, detoxification, anti-virulence and thrombolysis. Herein, recent advances on CMHSNCs are reviewed for delivery of various cargoes including drugs, genes, peptides, proteins, antigens/adjuvants, photoactivatable agents and probes. In addition, the challenges and possible future directions of the CMHSNCs for fundamental research and clinical translation are discussed.

Graphical abstract: Cell membrane-engineered hybrid soft nanocomposites for biomedical applications

Article information

Article type
Review Article
Submitted
20 фев 2020
Accepted
04 май 2020
First published
12 май 2020

J. Mater. Chem. B, 2020,8, 5578-5596

Cell membrane-engineered hybrid soft nanocomposites for biomedical applications

Y. Li, Y. Gan, C. Li, Y. Y. Yang, P. Yuan and X. Ding, J. Mater. Chem. B, 2020, 8, 5578 DOI: 10.1039/D0TB00472C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements